help button home button Am J Pathol ASIP WHAT IS IT?
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gerber, M. A.
Right arrow Articles by Thung, S. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gerber, M. A.
Right arrow Articles by Thung, S. N.

American Journal of Pathology, Vol 98, 395-400, Copyright © 1980 by American Society for Investigative Pathology

REGULAR ARTICLES

Enzyme patterns in human hepatocellular carcinoma

MA Gerber and SN Thung

Characteristic enzyme alterations have been demonstrated during the stages of experimental hepatocarcinogenesis in rats. The activity of gamma-glutamyl transpeptidase (GGTPase) in hyperplastic and neoplastic hepatocytes is usually increased, whereas that of canalicular adenosine triphosphatase (ATPase) and of glucose-6-phosphatase (G6Pase) is more variable. The activities of these marker enzymes were studied by histochemical techniques in 10 human hepatocellular carcinomas (HCCs), 1 liver cell adenoma, and 1 cholangiocarcinoma of liver. In 9 cases, the nontumorous liver was also examined. All HCCs, but not the liver cell adenoma, displayed enzyme patterns that differed from normal. GGTPase activity was markedly increased in 8 HCCs, whereas the activities of G6Pase and ATPase were lost in 6 and 8 HCCs, respectively. These enzyme alterations occurred as 5 of 7 possible combinations, resulting in significant heterogeneity of enzyme phenotypes, similar to that in experimental hepatocarcinogenesis.


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
A. Komlosh, G. Volohonsky, N. Porat, C. Tuby, E. Bluvshtein, P. Steinberg, F. Oesch, and A. A. Stark
{gamma}-Glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines
Carcinogenesis, April 1, 2002; 23(4): 669 - 678.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Komlosh, G. Volohonsky, N. Porat, C. Tuby, E. Bluvshtein, P. Steinberg, F. Oesch, and A. A. Stark
{gamma}-Glutamyl transpeptidase and glutathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines
Carcinogenesis, December 1, 2001; 22(12): 2009 - 2016.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by the American Society for Investigative Pathology.