help button home button Am J Pathol International Conference on Pathology of Chest Diseases
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Williams, G. M.
Right arrow Articles by Watanabe, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Williams, G. M.
Right arrow Articles by Watanabe, K.

American Journal of Pathology, Vol 99, 1-12, Copyright © 1980 by American Society for Investigative Pathology

REGULAR ARTICLES

The persistence and phenotypic stability of transplanted rat liver neoplastic nodules

GM Williams, T Ohmori and K Watanabe

Fragments of normal rat liver and nodular hepatocellular lesions produced by feeding rats 0.02% N-2-fluorenylacetamide for 20 weeks were transplanted into the inguinal mammary fat pad of syngeneic male rats. Five of 29 fragments of normal liver survived in the transplant site for up to 32 weeks after transplantation. Six of 20 nodules classified as neoplastic nodules and 2 of 5 with atypicality persisted and retained their morphologic abnormalities. Persisting fragments of normal liver accumulated iron when the recipient rats were iron-loaded by the feeding of 8-hydroxyquinoline and ferrous gluconate, but the nodule cells remained resistant to iron accumulation. Mitotic figures were present in nodule cells, but progressive growth did not occur. Four carcinoma transplants readily gave rise to tumors. Three of the tumors that developed in the transplant site from carcinomas were well- differentiated adenocarcinomas with mucin production. It was concluded that rat liver neoplastic nodules are phenotypically stable but differ from liver carcinomas in their biologic behavior in this system.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by the American Society for Investigative Pathology.