help button home button Am J Pathol ASIP 2008 Summer Academy, Molecular Methcanisms of Human Disease: Injury, Inflammation, and Tissue Repair
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Order Full text via Infotrieve
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ciocca, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ciocca, D. R.

American Journal of Pathology, Vol 99, 193-206, Copyright © 1980 by American Society for Investigative Pathology

REGULAR ARTICLES

Immunomorphologic lymph node changes in rats bearing experimental breast tumors

DR Ciocca

In this paper regional lymph nodes draining tumors and also nonregional lymph nodes have been studied at the light- and electron-microscopic levels. These nodes were obtained from rats bearing long-evolving autochthonous breast cancers. They were compared with a control group of the same age. A morphometric quantitative analysis was done to evaluate immunologically competent cell populations. In the experimental group there were no differences between regional and distal lymph nodes in the tumor challenge. However, when the experimental group was compared with the control group, differences appeared. The changes involved were diminution of the paracortical area with stimulation of plasma cells in the medullary cords. Ultrastructurally, in lymph nodes of the experimental group there were lymphoblasts in the paracortex and germinal centers, suggesting active lymphopoiesis. In addition, many plasma cells showed morphologic evidence of involution or other alterations. It is suggested that regional and distal lymph nodes have similar morphologic behavior when the tumor grows for a long period of time, a finding that contributes to our knowledge of the systemic implications of the lymphatic system.


This article has been cited by other articles:


Home page
 Cancer Res.Home page
H. Nagata, T. Arai, Y. Soejima, H. Suzuki, H. Ishii, and T. Hibi
Limited Capability of Regional Lymph Nodes to Eradicate Metastatic Cancer Cells
Cancer Res., November 15, 2004; 64(22): 8239 - 8248.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by the American Society for Investigative Pathology.