This Article Order Full text via Infotrieve Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ryan, J. L. Articles by Morrison, D. C. Search for Related Content PubMed PubMed Citation Articles by Ryan, J. L. Articles by Morrison, D. C.

American Journal of Pathology, Vol 99, 451-461, Copyright © 1980 by American Society for Investigative Pathology

REGULAR ARTICLES

Stimulation of peritoneal cell arginase by bacterial lipopolysaccharides

JL Ryan, WB Yohe and DC Morrison

The conditions under which bacterial endotoxins stimulate arginase production in mouse peritoneal macrophages have been defined. Both lipid-A and lipid-A-associated protein are potent activators. Fetal calf serum and normal mouse serum enhance macrophage arginase levels in the presence and absence of lipopolysaccharide (LPS). LPS in the amount of 10(-1) microgram/ml represents a maximal stimulus for macrophage arginase production and release. Thioglycollate-elicited peritoneal cells have increased arginase activity, compared with resident cells. This activity can be stimulated further by the addition of LPS. Arginase levels may alter the outcome of in vitro immunologic processes by depleting arginine and may also serve as a useful indicator of the state of activation of macrophages.

This article has been cited by other articles:

				C.-I Chang, J. C. Liao, and L. Kuo Macrophage Arginase Promotes Tumor Cell Growth and Suppresses Nitric Oxide-mediated Tumor Cytotoxicity Cancer Res., February 1, 2001; 61(3): 1100 - 1106. [Abstract] [Full Text]

				C. A. Louis, V. Mody, W. L. Henry Jr., J. S. Reichner, and J. E. Albina Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R237 - R242. [Abstract] [Full Text] [PDF]

				C.-I Chang, J. C. Liao, and L. Kuo Arginase modulates nitric oxide production in activated macrophages Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H342 - H348. [Abstract] [Full Text] [PDF]