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Originally published online as doi:10.2353/ajpath.2007.070342 on June 28, 2007

Published online before print June 28, 2007
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(American Journal of Pathology. 2007;171:375-385.)
© 2007 American Society for Investigative Pathology
DOI: 10.2353/ajpath.2007.070342

Amgen Award Lecture

A Perspective on DNA Microarrays in Pathology Research and Practice

Jonathan R. Pollack

From the Department of Pathology, Stanford University, Stanford, California

Abstract

DNA microarray technology matured in the mid-1990s, and the past decade has witnessed a tremendous growth in its application. DNA microarrays have provided powerful tools for pathology researchers seeking to describe, classify, and understand human disease. There has also been great expectation that the technology would advance the practice of pathology. This review highlights some of the key contributions of DNA microarrays to experimental pathology, focusing in the area of cancer research. Also discussed are some of the current challenges in translating utility to clinical practice.






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Copyright © 2007 by the American Society for Investigative Pathology.