Editorials: Jay M. McDonald, Gene P. Siegal, and Maria Gloria Eisemann Evolutionary Change and The American Journal of Pathology Am J Pathol 2004 165: 1055-1056. [Full Text]

Reviews: Pierre Chaurand, Melinda E. Sanders, Roy A. Jensen, and Richard M. Caprioli Proteomics in Diagnostic Pathology: Profiling and Imaging Proteins Directly in Tissue Sections Am J Pathol 2004 165: 1057-1068. [Abstract] [Full Text]

Commentaries: Yuqing E. Chen MMP-12, An Old Enzyme Plays a New Role in the Pathogenesis of Rheumatoid Arthritis? Am J Pathol 2004 165: 1069-1070. [Full Text]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Hong Wei Chu, Silvana Balzar, Gregory J. Seedorf, Jay Y. Westcott, John B. Trudeau, Phil Silkoff, and Sally E. Wenzel Transforming Growth Factor-ß2 Induces Bronchial Epithelial Mucin Expression in Asthma Am J Pathol 2004 165: 1097-1106. [Abstract] [Full Text]   Sian V. Griffin, Keiju Hiromura, Jeffrey Pippin, Arndt T. Petermann, Mary J. Blonski, Ron Krofft, Satoru Takahashi, Ashok B. Kulkarni, and Stuart J. Shankland Cyclin-Dependent Kinase 5 Is a Regulator of Podocyte Differentiation, Proliferation, and Morphology Am J Pathol 2004 165: 1175-1185. [Abstract] [Full Text]   Atsuko Kamijo, Takeshi Sugaya, Akihisa Hikawa, Mitsuhiro Okada, Fumikazu Okumura, Masaya Yamanouchi, Akiko Honda, Masaru Okabe, Tomoya Fujino, Yasunobu Hirata, Masao Omata, Ritsuko Kaneko, Hiroshi Fujii, Akiyoshi Fukamizu, and Kenjiro Kimura Urinary Excretion of Fatty Acid-Binding Protein Reflects Stress Overload on the Proximal Tubules Am J Pathol 2004 165: 1243-1255. [Abstract] [Full Text]   Christy C. Bridges and Rudolfs K. Zalups Homocysteine, System b0,+ and the Renal Epithelial Transport and Toxicity of Inorganic Mercury Am J Pathol 2004 165: 1385-1394. [Abstract] [Full Text]

Cell Injury, Repair, Aging and Apoptosis: Allan M. Ramirez, Shinsuke Takagawa, Marin Sekosan, H. Ari Jaffe, John Varga, and Jesse Roman Smad3 Deficiency Ameliorates Experimental Obliterative Bronchiolitis in a Heterotopic Tracheal Transplantation Model Am J Pathol 2004 165: 1223-1232. [Abstract] [Full Text]   Takayuki Nakagomi, Osamu Kitada, Kozo Kuribayashi, Hiroo Yoshikawa, Kentaro Ozawa, Satoshi Ogawa, and Tomohiro Matsuyama The 150-Kilodalton Oxygen-Regulated Protein Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice Am J Pathol 2004 165: 1279-1288. [Abstract] [Full Text]   Jungkee Kwon, Yu-Lai Wang, Rieko Setsuie, Satoshi Sekiguchi, Yae Sato, Mikako Sakurai, Mami Noda, Shunsuke Aoki, Yasuhiro Yoshikawa, and Keiji Wada Two Closely Related Ubiquitin C-Terminal Hydrolase Isozymes Function as Reciprocal Modulators of Germ Cell Apoptosis in Cryptorchid Testis Am J Pathol 2004 165: 1367-1374. [Abstract] [Full Text]

Gastrointestinal, Hepatobiliary and Pancreatic Pathology: Susana Aguilar, Josep M. Corominas, Núria Malats, José A. Pereira, Marlène Dufresne, Francisco X. Real, and Pilar Navarro Tissue Plasminogen Activator in Murine Exocrine Pancreas Cancer: Selective Expression in Ductal Tumors and Contribution to Cancer Progression Am J Pathol 2004 165: 1129-1139. [Abstract] [Full Text]   Bence Sipos, Wolfram Klapper, Marie-Luise Kruse, Holger Kalthoff, Dontscho Kerjaschki, and Günter Klöppel Expression of Lymphangiogenic Factors and Evidence of Intratumoral Lymphangiogenesis in Pancreatic Endocrine Tumors Am J Pathol 2004 165: 1187-1197. [Abstract] [Full Text]   Heike Steiling, Marcus Mühlbauer, Frauke Bataille, Jürgen Schölmerich, Sabine Werner, and Claus Hellerbrand Activated Hepatic Stellate Cells Express Keratinocyte Growth Factor in Chronic Liver Disease Am J Pathol 2004 165: 1233-1241. [Abstract] [Full Text]   Taeko Dohi, Kohtaro Fujihashi, Toshiya Koga, Yuri Etani, Naoto Yoshino, Yuki I. Kawamura, and Jerry R. McGhee CD4+CD45RBHi Interleukin-4 Defective T Cells Elicit Antral Gastritis and Duodenitis Am J Pathol 2004 165: 1257-1268. [Abstract] [Full Text]

Immunopathology and Infectious Disease: Ramesh Prabhu, Nutan Khalap, Roberto Burioni, Massimo Clementi, Robert F. Garry, and Srikanta Dash Inhibition of Hepatitis C Virus Nonstructural Protein, Helicase Activity, and Viral Replication by a Recombinant Human Antibody Clone Am J Pathol 2004 165: 1163-1173. [Abstract] [Full Text]   Bo-Chin Chiu, Christine M. Freeman, Valerie R. Stolberg, Jerry S. Hu, Kyriaki Zeibecoglou, Bao Lu, Craig Gerard, Israel F. Charo, Sergio A. Lira, and Stephen W. Chensue Impaired Lung Dendritic Cell Activation in CCR2 Knockout Mice Am J Pathol 2004 165: 1199-1209. [Abstract] [Full Text]   Claudia Jakubzick, Haitao Wen, Akihiro Matsukawa, Maya Keller, Steven L. Kunkel, and Cory M. Hogaboam Role of CCR4 Ligands, CCL17 and CCL22, During Schistosoma mansoni Egg-Induced Pulmonary Granuloma Formation in Mice Am J Pathol 2004 165: 1211-1221. [Abstract] [Full Text]   Douglas D. Bannerman, Kristine T. Eiting, Robert K. Winn, and John M. Harlan FLICE-Like Inhibitory Protein (FLIP) Protects Against Apoptosis and Suppresses NF-B Activation Induced by Bacterial Lipopolysaccharide Am J Pathol 2004 165: 1423-1431. [Abstract] [Full Text]   Jorge G. Ganopolsky and Francis J. Castellino A Protein C Deficiency Exacerbates Inflammatory and Hypotensive Responses in Mice During Polymicrobial Sepsis in a Cecal Ligation and Puncture Model Am J Pathol 2004 165: 1433-1446. [Abstract] [Full Text]

Matrix Pathobiology: Edward V. Maytin, Helen H. Chung, and V. Mani Seetharaman Hyaluronan Participates in the Epidermal Response to Disruption of the Permeability Barrier in Vivo Am J Pathol 2004 165: 1331-1341. [Abstract] [Full Text]   Xiaofei Wang, Jingyan Liang, Tomonari Koike, Huijun Sun, Tomonaga Ichikawa, Shuji Kitajima, Masatoshi Morimoto, Hisataka Shikama, Teruo Watanabe, Yasuyuki Sasaguri, and Jianglin Fan Overexpression of Human Matrix Metalloproteinase-12 Enhances the Development of Inflammatory Arthritis in Transgenic Rabbits Am J Pathol 2004 165: 1375-1383. [Abstract] [Full Text]

Molecular Pathogenesis of Genetic and Inherited Diseases: Lixin Kan, Min Hu, William A. Gomes, and John A. Kessler Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva (FOP)-Like Phenotype Am J Pathol 2004 165: 1107-1115. [Abstract] [Full Text]   Xianghong Zhu, Andrew M. Herzenberg, Mohammad Eskandarian, Graham F. Maguire, James W. Scholey, Philip W. Connelly, and Dominic S. Ng A Novel in Vivo Lecithin-Cholesterol Acyltransferase (LCAT)-Deficient Mouse Expressing Predominantly LpX Is Associated with Spontaneous Glomerulopathy Am J Pathol 2004 165: 1269-1278. [Abstract] [Full Text]   Joon Whan Rhee, Akiko Arata, Licia Selleri, Yakop Jacobs, Satoru Arata, Hiroshi Onimaru, and Michael L. Cleary Pbx3 Deficiency Results in Central Hypoventilation Am J Pathol 2004 165: 1343-1350. [Abstract] [Full Text]

Neurobiology: Caty Casas, Nicolas Sergeant, Jean-Michel Itier, Véronique Blanchard, Oliver Wirths, Nicolien van der Kolk, Valérie Vingtdeux, Evita van de Steeg, Gwenaëlle Ret, Thierry Canton, Hervé Drobecq, Allan Clark, Bruno Bonici, André Delacourte, Jesús Benavides, Christoph Schmitz, Günter Tremp, Thomas A. Bayer, Patrick Benoit, and Laurent Pradier Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aß42 Accumulation in a Novel Alzheimer Transgenic Model Am J Pathol 2004 165: 1289-1300. [Abstract] [Full Text] Supplemental Material   Anne M. Fagan, Erin Christopher, Jennie W. Taylor, Maia Parsadanian, Michael Spinner, Melanie Watson, John D. Fryer, Suzanne Wahrle, Kelly R. Bales, Steven M. Paul, and David M. Holtzman ApoAI Deficiency Results in Marked Reductions in Plasma Cholesterol But No Alterations in Amyloid-ß Pathology in a Mouse Model of Alzheimer’s Disease-Like Cerebral Amyloidosis Am J Pathol 2004 165: 1413-1422. [Abstract] [Full Text]

Stem Cells, Tissue Engineering and Hematopoietic Elements: Margarida Lima, Julia Almeida, Andrés García Montero, Maria dos Anjos Teixeira, Maria Luís Queirós, Ana Helena Santos, Ana Balanzategui, Alexandra Estevinho, Maria del Cármen Algueró, Paloma Barcena, Sónia Fonseca, Maria Luís Amorim, José Manuel Cabeda, Luciana Pinho, Marcos Gonzalez, Jesus San Miguel, Benvindo Justiça, and Alberto Orfão Clinicobiological, Immunophenotypic, and Molecular Characteristics of Monoclonal CD56–/+dim Chronic Natural Killer Cell Large Granular Lymphocytosis Am J Pathol 2004 165: 1117-1127. [Abstract] [Full Text]   Keisuke Oboki, Eiichi Morii, and Yukihiko Kitamura Deficient Eosinophil Chemotaxis-Promoting Activity of Genetically Normal Mast Cells Transplanted into Subcutaneous Tissue of Mitfmi-vga9/Mitfmi-vga9 Mice: Comparison of the Activity and Mast Cell Distribution Pattern with KitW/KitW-vMice Am J Pathol 2004 165: 1141-1150. [Abstract] [Full Text]

Tumorigenesis and Neoplastic Progression: Anil K. Sood, Jeremy E. Coffin, Galen B. Schneider, Mavis S. Fletcher, Barry R. DeYoung, Lynn M. Gruman, David M. Gershenson, Michael D. Schaller, and Mary J.C. Hendrix Biological Significance of Focal Adhesion Kinase in Ovarian Cancer: Role in Migration and Invasion Am J Pathol 2004 165: 1087-1095. [Abstract] [Full Text]   Annalisa R. Stone, William Bobo, Daniel J. Brat, Nara S. Devi, Erwin G. Van Meir, and Paula M. Vertino Aberrant Methylation and Down-Regulation of TMS1/ASC in Human Glioblastoma Am J Pathol 2004 165: 1151-1161. [Abstract] [Full Text]   Xiaodong Shen and Randall H. Kramer Adhesion-Mediated Squamous Cell Carcinoma Survival through Ligand-Independent Activation of Epidermal Growth Factor Receptor Am J Pathol 2004 165: 1315-1329. [Abstract] [Full Text]   Panagiotis Karakaidos, Stavros Taraviras, Leandros V. Vassiliou, Panayotis Zacharatos, Nikolaos G. Kastrinakis, Dionysia Kougiou, Mirsini Kouloukoussa, Hideo Nishitani, Athanasios G. Papavassiliou, Zoi Lygerou, and Vassilis G. Gorgoulis Overexpression of the Replication Licensing Regulators hCdt1 and hCdc6 Characterizes a Subset of Non-Small-Cell Lung Carcinomas: Synergistic Effect with Mutant p53 on Tumor Growth and Chromosomal Instability—Evidence of E2F-1 Transcriptional Control over hCdt1 Am J Pathol 2004 165: 1351-1365. [Abstract] [Full Text]   Ryan P. McCarthy, Shaobo Zhang, David G. Bostwick, Junqi Qian, John N. Eble, Mingsheng Wang, Haiqun Lin, and Liang Cheng Molecular Genetic Evidence for Different Clonal Origins of Epithelial and Stromal Components of Phyllodes Tumor of the Prostate Am J Pathol 2004 165: 1395-1400. [Abstract] [Full Text]

Vascular Biology, Atherosclerosis and Endothelium Biology: Peter Baluk, Chun Geun Lee, Holger Link, Erin Ator, Amy Haskell, Jack A. Elias, and Donald M. McDonald Regulated Angiogenesis and Vascular Regression in Mice Overexpressing Vascular Endothelial Growth Factor in Airways Am J Pathol 2004 165: 1071-1085. [Abstract] [Full Text]   Tailoi Chan-Ling, Matthew Philip Page, Tom Gardiner, Louise Baxter, Emilia Rosinova, and Suzanne Hughes Desmin Ensheathment Ratio as an Indicator of Vessel Stability: Evidence in Normal Development and in Retinopathy of Prematurity Am J Pathol 2004 165: 1301-1313. [Abstract] [Full Text]   Chryso Kanthou, Olga Greco, Anna Stratford, Ian Cook, Richard Knight, Omar Benzakour, and Gillian Tozer The Tubulin-Binding Agent Combretastatin A-4-Phosphate Arrests Endothelial Cells in Mitosis and Induces Mitotic Cell Death Am J Pathol 2004 165: 1401-1411. [Abstract] [Full Text]

Correction: Correction Am J Pathol 2004 165: 1447. [Full Text]

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