The Cover: Genes with known functions that are highly expressed in mesothelioma were used to create a large network of interrelated physiological pathways, a small portion of which is shown here (the expanded network can be seen on http://ajp.amjpathol.org). The intensity of the node color (red) corresponds to the fold-increase in average gene expression levels relative to normal tissues, which is listed immediately below the gene abbreviation of relevant nodes. (See page 1827).