The Cover: Background: Ultrastructural analysis of thalamic microvessel in a mutant APP transgenic mouse (Tg-SwDl) showing several sites of amyloid deposition breaching the vascular basement membrane (arrowhead). Microglial cells (M) and vessel lumen (L) are noted. (See page 505.) Foreground: Model for dense plaque formation and vascular remodeling in mutant APP transgenic mice (Tg2576 and PSAPP). (See page 527.)

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