The Cover: Center: Hollow-fiber bioreactor used for long-term fetal hepatocyte culture contains three independent inter-woven hollow fiber membrane systems (illustrated in lower right panel). Foreground: Histological characterization of neo-liver formation demonstrates the presence of various physiological cell types. Clockwise starting with bottom panel: αFP+ bipotential stem cells, H&E-stained hepatocytes, albumin+ differentiated hepatocytes, αSMA+ mesenchymal cells, isolectin+ endothelial cells, CK-19+ bipotential stem cells, and C-Kit+ bipotential stem cells. (See page 1279).

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