Editorials: Jay M. McDonald, Gene P. Siegal, and Peter A. Ward Introducing Biological Perspectives Am J Pathol 2006 169: 337. [Full Text] [PDF]

Biological Perspectives: David Bryder, Derrick J. Rossi, and Irving L. Weissman Hematopoietic Stem Cells: The Paradigmatic Tissue-Specific Stem Cell Am J Pathol 2006 169: 338-346. [Abstract] [Full Text] [PDF]

Commentaries: M. Luisa Iruela-Arispe When It Comes to Blocking Lymphatics, It Is All a Question of Time Am J Pathol 2006 169: 347-350. [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Michael Karl, Mariana Berho, Judith Pignac-Kobinger, Gary E. Striker, and Sharon J. Elliot Differential Effects of Continuous and Intermittent 17ß-Estradiol Replacement and Tamoxifen Therapy on the Prevention of Glomerulosclerosis: Modulation of the Mesangial Cell Phenotype in Vivo Am J Pathol 2006 169: 351-361. [Abstract] [Full Text] [PDF]   Yasuhiro Nakamura, Saya Suzuki, Takashi Suzuki, Katsuhiko Ono, Ikumi Miura, Fumitoshi Satoh, Takuya Moriya, Haruo Saito, Shogo Yamada, Sadayoshi Ito, and Hironobu Sasano MDM2: A Novel Mineralocorticoid-Responsive Gene Involved in Aldosterone-Induced Human Vascular Structural Remodeling Am J Pathol 2006 169: 362-371. [Abstract] [Full Text] [PDF]   Kengo Furuichi, Ji-Liang Gao, and Philip M. Murphy Chemokine Receptor CX3CR1 Regulates Renal Interstitial Fibrosis after Ischemia-Reperfusion Injury Am J Pathol 2006 169: 372-387. [Abstract] [Full Text] [PDF]

Cell Injury, Repair, Aging and Apoptosis: Tiina Kipari, Jean-Francois Cailhier, David Ferenbach, Simon Watson, Kris Houlberg, David Walbaum, Spike Clay, John Savill, and Jeremy Hughes Nitric Oxide Is an Important Mediator of Renal Tubular Epithelial Cell Death in Vitro and in Murine Experimental Hydronephrosis Am J Pathol 2006 169: 388-399. [Abstract] [Full Text] [PDF]   May Lee Tjoa, Tereza Cindrova-Davies, Olivera Spasic-Boskovic, Diana W. Bianchi, and Graham J. Burton Trophoblastic Oxidative Stress and the Release of Cell-Free Feto-Placental DNA Am J Pathol 2006 169: 400-404. [Abstract] [Full Text] [PDF]

Epithelial and Mesenchymal Cell Biology: Jun Araya, Stephanie Cambier, Alanna Morris, Walter Finkbeiner, and Stephen L. Nishimura Integrin-Mediated Transforming Growth Factor-ß Activation Regulates Homeostasis of the Pulmonary Epithelial-Mesenchymal Trophic Unit Am J Pathol 2006 169: 405-415. [Abstract] [Full Text] [PDF]   Ken Arita, Masashi Akiyama, Tomoyasu Aizawa, Yoshitaka Umetsu, Ikuo Segawa, Maki Goto, Daisuke Sawamura, Makoto Demura, Keiichi Kawano, and Hiroshi Shimizu A Novel N14Y Mutation in Connexin26 in Keratitis-Ichthyosis-Deafness Syndrome: Analyses of Altered Gap Junctional Communication and Molecular Structure of N Terminus of Mutated Connexin26 Am J Pathol 2006 169: 416-423. [Abstract] [Full Text] [PDF]

Immunopathology and Infectious Disease: Jerry S. Hu, Christine M. Freeman, Valerie R. Stolberg, Bo Chin Chiu, Gary J. Bridger, Simon P. Fricker, Nicholas W. Lukacs, and Stephen W. Chensue AMD3465, a Novel CXCR4 Receptor Antagonist, Abrogates Schistosomal Antigen-Elicited (Type-2) Pulmonary Granuloma Formation Am J Pathol 2006 169: 424-432. [Abstract] [Full Text] [PDF]   Deborah J. Stearns-Kurosawa, Florea Lupu, Fletcher B. Taylor, Jr., Gary Kinasewitz, and Shinichiro Kurosawa Sepsis and Pathophysiology of Anthrax in a Nonhuman Primate Model Am J Pathol 2006 169: 433-444. [Abstract] [Full Text] [PDF]

Matrix Pathobiology: Seiji Goda, Hiroshi Inoue, Hisanori Umehara, Michihiko Miyaji, Yutaka Nagano, Nari Harakawa, Hisao Imai, Peter Lee, James B. MaCarthy, Takashi Ikeo, Naochika Domae, Yoji Shimizu, and Joji Iida Matrix Metalloproteinase-1 Produced by Human CXCL12-Stimulated Natural Killer Cells Am J Pathol 2006 169: 445-458. [Abstract] [Full Text] [PDF]   Karen J. Aitken, Gregory Block, Armando Lorenzo, Daniel Herz, Nesrin Sabha, Omar Dessouki, France Fung, Marta Szybowska, Laura Craig, and Darius J. Bägli Mechanotransduction of Extracellular Signal-Regulated Kinases 1 and 2 Mitogen-Activated Protein Kinase Activity in Smooth Muscle Is Dependent on the Extracellular Matrix and Regulated by Matrix Metalloproteinases Am J Pathol 2006 169: 459-470. [Abstract] [Full Text] [PDF]   Oliver Bock, Johanne Neuse, Kais Hussein, Kai Brakensiek, Guntram Buesche, Thomas Buhr, Birgitt Wiese, and Hans Kreipe Aberrant Collagenase Expression in Chronic Idiopathic Myelofibrosis Is Related to the Stage of Disease but Not to the JAK2 Mutation Status Am J Pathol 2006 169: 471-481. [Abstract] [Full Text] [PDF]   TaiHao Quan, TianYuan He, Yuan Shao, Lin Lin, Sewon Kang, John J. Voorhees, and Gary J. Fisher Elevated Cysteine-Rich 61 Mediates Aberrant Collagen Homeostasis in Chronologically Aged and Photoaged Human Skin Am J Pathol 2006 169: 482-490. [Abstract] [Full Text] [PDF]

Musculoskeletal Pathology: Claudia Grimmer, Nadine Balbus, Ute Lang, Thomas Aigner, Thorsten Cramer, Lutz Müller, Bernd Swoboda, and David Pfander Regulation of Type II Collagen Synthesis during Osteoarthritis by Prolyl-4-Hydroxylases: Possible Influence of Low Oxygen Levels Am J Pathol 2006 169: 491-502. [Abstract] [Full Text] [PDF]   Kirk H.M. Yip, Haotian Feng, Nathan J. Pavlos, Ming H. Zheng, and Jiake Xu p62 Ubiquitin Binding-Associated Domain Mediated the Receptor Activator of Nuclear Factor-B Ligand-Induced Osteoclast Formation: A New Insight into the Pathogenesis of Paget’s Disease of Bone Am J Pathol 2006 169: 503-514. [Abstract] [Full Text] [PDF]   Louise van der Weyden, Lei Wei, Junming Luo, Xu Yang, David E. Birk, David J. Adams, Allan Bradley, and Qian Chen Functional Knockout of the Matrilin-3 Gene Causes Premature Chondrocyte Maturation to Hypertrophy and Increases Bone Mineral Density and Osteoarthritis Am J Pathol 2006 169: 515-527. [Abstract] [Full Text] [PDF]

Neurobiology: Justin Tan and Robert K. Shepherd Aminoglycoside-Induced Degeneration of Adult Spiral Ganglion Neurons Involves Differential Modulation of Tyrosine Kinase B and p75 Neurotrophin Receptor Signaling Am J Pathol 2006 169: 528-543. [Abstract] [Full Text] [PDF]   Oliver Ambrée, Uwe Leimer, Arne Herring, Nicole Görtz, Norbert Sachser, Michael T. Heneka, Werner Paulus, and Kathy Keyvani Reduction of Amyloid Angiopathy and Aß Plaque Burden after Enriched Housing in TgCRND8 Mice: Involvement of Multiple Pathways Am J Pathol 2006 169: 544-552. [Abstract] [Full Text] [PDF] Supplemental Material   Kunikazu Tanji, Tomoaki Tanaka, Fumiaki Mori, Katsumi Kito, Hitoshi Takahashi, Koichi Wakabayashi, and Tetsu Kamitani NUB1 Suppresses the Formation of Lewy Body-Like Inclusions by Proteasomal Degradation of Synphilin-1 Am J Pathol 2006 169: 553-565. [Abstract] [Full Text] [PDF]   Faisal Adhami, Guanghong Liao, Yury M. Morozov, Aryn Schloemer, Vincent J. Schmithorst, John N. Lorenz, R. Scott Dunn, Charles V. Vorhees, Marsha Wills-Karp, Jay L. Degen, Roger J. Davis, Noboru Mizushima, Pasko Rakic, Bernard J. Dardzinski, Scott K. Holland, Frank R. Sharp, and Chia-Yi Kuan Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy Am J Pathol 2006 169: 566-583. [Abstract] [Full Text] [PDF]   Tanja Kuhlmann, Leah Remington, Isabelle Cognet, Lyne Bourbonniere, Simone Zehntner, Florence Guilhot, Alexandra Herman, Angélique Guay-Giroux, Jack P. Antel, Trevor Owens, and Jean-François Gauchat Continued Administration of Ciliary Neurotrophic Factor Protects Mice from Inflammatory Pathology in Experimental Autoimmune Encephalomyelitis Am J Pathol 2006 169: 584-598. [Abstract] [Full Text] [PDF]   Katharina Schindowski, Alexis Bretteville, Karelle Leroy, Séverine Bégard, Jean-Pierre Brion, Malika Hamdane, and Luc Buée Alzheimer’s Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits Am J Pathol 2006 169: 599-616. [Abstract] [Full Text] [PDF] Supplemental Material

Tumorigenesis and Neoplastic Progression: Sabine Hombach-Klonisch, Joanna Bialek, Bogusz Trojanowicz, Ekkehard Weber, Hans-Jürgen Holzhausen, Josh D. Silvertown, Alastair J. Summerlee, Henning Dralle, Cuong Hoang-Vu, and Thomas Klonisch Relaxin Enhances the Oncogenic Potential of Human Thyroid Carcinoma Cells Am J Pathol 2006 169: 617-632. [Abstract] [Full Text] [PDF]   Jennifer Dien, Hesham M. Amin, Neil Chiu, Winson Wong, Christine Frantz, Brian Chiu, John R. Mackey, and Raymond Lai Signal Transducers and Activators of Transcription-3 Up-Regulates Tissue Inhibitor of Metalloproteinase-1 Expression and Decreases Invasiveness of Breast Cancer Am J Pathol 2006 169: 633-642. [Abstract] [Full Text] [PDF]   Marcella Marcellini, Naomi De Luca, Teresa Riccioni, Alessandro Ciucci, Angela Orecchia, Pedro Miguel Lacal, Federica Ruffini, Maurizio Pesce, Francesca Cianfarani, Giovanna Zambruno, Augusto Orlandi, and Cristina Maria Failla Increased Melanoma Growth and Metastasis Spreading in Mice Overexpressing Placenta Growth Factor Am J Pathol 2006 169: 643-654. [Abstract] [Full Text] [PDF]   Christoph Renné, Jose Ignacio Martin-Subero, Maren Eickernjäger, Martin-Leo Hansmann, Ralf Küppers, Reiner Siebert, and Andreas Bräuninger Aberrant Expression of ID2, a Suppressor of B-Cell-Specific Gene Expression, in Hodgkin’s Lymphoma Am J Pathol 2006 169: 655-664. [Abstract] [Full Text] [PDF] Supplemental Material   Damia Tormo, Aleix Ferrer, Evelyn Gaffal, Jörg Wenzel, Etiena Basner-Tschakarjan, Julia Steitz, Lukas C. Heukamp, Ines Gütgemann, Reinhard Buettner, Marcos Malumbres, Mariano Barbacid, Glenn Merlino, and Thomas Tüting Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation Am J Pathol 2006 169: 665-672. [Abstract] [Full Text] [PDF]   Mika Suzuki, Evangeline Sari Mose, Valerie Montel, and David Tarin Dormant Cancer Cells Retrieved from Metastasis-Free Organs Regain Tumorigenic and Metastatic Potency Am J Pathol 2006 169: 673-681. [Abstract] [Full Text] [PDF] Supplemental Material   Xin Yuan, Tong Li, Hongyun Wang, Tao Zhang, Moumita Barua, Robert A. Borgesi, Glenn J. Bubley, Michael L. Lu, and Steven P. Balk Androgen Receptor Remains Critical for Cell-Cycle Progression in Androgen-Independent CWR22 Prostate Cancer Cells Am J Pathol 2006 169: 682-696. [Abstract] [Full Text] [PDF]

Vascular Biology, Atherosclerosis and Endothelium Biology: Yasuhiro Miyazaki, Takahiro Satoh, Kiyoshi Nishioka, and Hiroo Yokozeki STAT-6-Mediated Control of P-Selectin by Substance P and Interleukin-4 in Human Dermal Endothelial Cells Am J Pathol 2006 169: 697-707. [Abstract] [Full Text] [PDF]   Terhi Karpanen, Maria Wirzenius, Taija Mäkinen, Tanja Veikkola, Hidde J. Haisma, Marc G. Achen, Steven A. Stacker, Bronislaw Pytowski, Seppo Ylä-Herttuala, and Kari Alitalo Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation Am J Pathol 2006 169: 708-718. [Abstract] [Full Text] [PDF] Supplemental Material   Téni G Ebrahimian, Christophe Heymes, Dong You, Olivier Blanc-Brude, Barend Mees, Ludovic Waeckel, Micheline Duriez, José Vilar, Ralph P. Brandes, Bernard I. Levy, Ajay M. Shah, and Jean-Sébastien Silvestre NADPH Oxidase-Derived Overproduction of Reactive Oxygen Species Impairs Postischemic Neovascularization in Mice with Type 1 Diabetes Am J Pathol 2006 169: 719-728. [Abstract] [Full Text] [PDF]

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