Reviews: Thomas Q. Nhan, W. Conrad Liles, and Stephen M. Schwartz Physiological Functions of Caspases Beyond Cell Death Am J Pathol 2006 169: 729-737. [Full Text] [PDF]

Commentaries: Hyoung-gon Lee, Xiongwei Zhu, Akihiko Nunomura, George Perry, and Mark A. Smith Amyloid-ß Vaccination: Testing the Amyloid Hypothesis?: Heads We Win, Tails You Lose! Am J Pathol 2006 169: 738-739. [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Mayuka Horikawa, Manabu Fujimoto, Minoru Hasegawa, Takashi Matsushita, Yasuhito Hamaguchi, Ayako Kawasuji, Yukiyo Matsushita, Tomoyuki Fujita, Fumihide Ogawa, Kazuhiko Takehara, Douglas A. Steeber, and Shinichi Sato E- and P-Selectins Synergistically Inhibit Bleomycin-Induced Pulmonary Fibrosis Am J Pathol 2006 169: 740-749. [Abstract] [Full Text] [PDF]   Ingrid Pruimboom-Brees, Mehrdad Haghpassand, Lori Royer, Dominique Brees, Charles Aldinger, William Reagan, Jatinder Singh, Roy Kerlin, Christopher Kane, Scott Bagley, Cheryl Hayward, James Loy, Peter O’Brien, and Omar L. Francone A Critical Role for Peroxisomal Proliferator-Activated Receptor- Nuclear Receptors in the Development of Cardiomyocyte Degeneration and Necrosis Am J Pathol 2006 169: 750-760. [Abstract] [Full Text] [PDF]

Cell Injury, Repair, Aging and Apoptosis: Sachiko Homma, Masahiro Iwasaki, G. Diane Shelton, Eva Engvall, John C. Reed, and Shinichi Takayama BAG3 Deficiency Results in Fulminant Myopathy and Early Lethality Am J Pathol 2006 169: 761-773. [Abstract] [Full Text] [PDF] Supplemental Material   Shannon A. Bainbridge, Louiza Belkacemi, Michelle Dickinson, Charles H. Graham, and Graeme N. Smith Carbon Monoxide Inhibits Hypoxia/Reoxygenation-Induced Apoptosis and Secondary Necrosis in Syncytiotrophoblast Am J Pathol 2006 169: 774-783. [Abstract] [Full Text] [PDF]   Frank Hildebrand, William J. Hubbard, Mashkoor A. Choudhry, Michael Frink, Hans-Christoph Pape, Steven L. Kunkel, and Irshad H. Chaudry Kupffer Cells and Their Mediators: The Culprits in Producing Distant Organ Damage after Trauma-Hemorrhage Am J Pathol 2006 169: 784-794. [Abstract] [Full Text] [PDF]   Peter Wolf, Dat X. Nghiem, Jeffrey P. Walterscheid, Scott Byrne, Yumi Matsumura, Yasuhiro Matsumura, Cora Bucana, Honnavara N. Ananthaswamy, and Stephen E. Ullrich Platelet-Activating Factor Is Crucial in Psoralen and Ultraviolet A-Induced Immune Suppression, Inflammation, and Apoptosis Am J Pathol 2006 169: 795-805. [Abstract] [Full Text] [PDF]

Epithelial and Mesenchymal Cell Biology: Marina Grachtchouk, Jianhong Liu, Aiqin Wang, Lebing Wei, Christopher K. Bichakjian, Jonathan Garlick, Augusto F. Paulino, Thomas Giordano, and Andrzej A. Dlugosz Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans Am J Pathol 2006 169: 806-814. [Abstract] [Full Text] [PDF]   Martin Metz, Verena Lammel, Bernhard F. Gibbs, and Marcus Maurer Inflammatory Murine Skin Responses to UV-B Light Are Partially Dependent on Endothelin-1 and Mast Cells Am J Pathol 2006 169: 815-822. [Abstract] [Full Text] [PDF]

Gastrointestinal, Hepatobiliary and Pancreatic Pathology: Yiru Xu, John J. Voorhees, and Gary J. Fisher Epidermal Growth Factor Receptor Is a Critical Mediator of Ultraviolet B Irradiation-Induced Signal Transduction in Immortalized Human Keratinocyte HaCaT Cells Am J Pathol 2006 169: 823-830. [Abstract] [Full Text] [PDF]   Motoko Sasaki, Hiroko Ikeda, Yasunori Sato, and Yasuni Nakanuma Decreased Expression of Bmi1 Is Closely Associated with Cellular Senescence in Small Bile Ducts in Primary Biliary Cirrhosis Am J Pathol 2006 169: 831-845. [Abstract] [Full Text] [PDF]   Gianluca Svegliati-Baroni, Cinzia Candelaresi, Stefania Saccomanno, Gianna Ferretti, Tiziana Bachetti, Marco Marzioni, Samuele De Minicis, Liliana Nobili, Renata Salzano, Alessia Omenetti, Deborah Pacetti, Soeren Sigmund, Antonio Benedetti, and Alessandro Casini A Model of Insulin Resistance and Nonalcoholic Steatohepatitis in Rats: Role of Peroxisome Proliferator-Activated Receptor- and n-3 Polyunsaturated Fatty Acid Treatment on Liver Injury Am J Pathol 2006 169: 846-860. [Abstract] [Full Text] [PDF]   Richard G. Ruddell, Fiona Oakley, Ziafat Hussain, Irene Yeung, Lesley J. Bryan-Lluka, Grant A. Ramm, and Derek A. Mann A Role for Serotonin (5-HT) in Hepatic Stellate Cell Function and Liver Fibrosis Am J Pathol 2006 169: 861-876. [Abstract] [Full Text] [PDF]   Domenico Alvaro, Barbara Barbaro, Antonio Franchitto, Paolo Onori, Shannon S. Glaser, Gianfranco Alpini, Heather Francis, Luca Marucci, Paola Sterpetti, Stefano Ginanni-Corradini, Andrea Onetti Muda, David E. Dostal, Adriano De Santis, Adolfo F. Attili, Antonio Benedetti, and Eugenio Gaudio Estrogens and Insulin-Like Growth Factor 1 Modulate Neoplastic Cell Growth in Human Cholangiocarcinoma Am J Pathol 2006 169: 877-888. [Abstract] [Full Text] [PDF]

Growth Factors, Cytokines, Cell Cycle Molecules: Jianhua Wang, Chuanyu Li, Yuelong Liu, Wan Mei, Shaohua Yu, Cunren Liu, Liming Zhang, Xu Cao, Robert P. Kimberly, William Grizzle, and Huang-Ge Zhang JAB1 Determines the Response of Rheumatoid Arthritis Synovial Fibroblasts to Tumor Necrosis Factor- Am J Pathol 2006 169: 889-902. [Abstract] [Full Text] [PDF]   Tara Aghaloo, Catherine M. Cowan, Yu-Fen Chou, Xinli Zhang, Haofu Lee, Steve Miao, Nichole Hong, Shun’ichi Kuroda, Benjamin Wu, Kang Ting, and Chia Soo Nell-1-Induced Bone Regeneration in Calvarial Defects Am J Pathol 2006 169: 903-915. [Abstract] [Full Text] [PDF]   Cong Yan, Xuemei Lian, Yuan Li, Ying Dai, Amanda White, Yulin Qin, Huimin Li, David A. Hume, and Hong Du Macrophage-Specific Expression of Human Lysosomal Acid Lipase Corrects Inflammation and Pathogenic Phenotypes in lal–/– Mice Am J Pathol 2006 169: 916-926. [Abstract] [Full Text] [PDF]

Immunopathology and Infectious Disease: Morag R. Graham, Kimmo Virtaneva, Stephen F. Porcella, Donald J. Gardner, R. Daniel Long, Diane M. Welty, William T. Barry, Claire A. Johnson, Larye D. Parkins, Fred A. Wright, and James M. Musser Analysis of the Transcriptome of Group A Streptococcus in Mouse Soft Tissue Infection Am J Pathol 2006 169: 927-942. [Abstract] [Full Text] [PDF] Supplemental Material   Mohammed F. Hassan, Yaobi Zhang, Christian R. Engwerda, Paul M. Kaye, Hannah Sharp, and Quentin D. Bickle The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani Am J Pathol 2006 169: 943-953. [Abstract] [Full Text] [PDF]   Minoru Hasegawa, Yasuhito Hamaguchi, Koichi Yanaba, Jean-David Bouaziz, Junji Uchida, Manabu Fujimoto, Takashi Matsushita, Yukiyo Matsushita, Mayuka Horikawa, Kazuhiro Komura, Kazuhiko Takehara, Shinichi Sato, and Thomas F. Tedder B-Lymphocyte Depletion Reduces Skin Fibrosis and Autoimmunity in the Tight-Skin Mouse Model for Systemic Sclerosis Am J Pathol 2006 169: 954-966. [Abstract] [Full Text] [PDF]   Xiaoyang Wang, Henrik Hagberg, Carina Mallard, Changlian Zhu, Maj Hedtjärn, Carl-Fredrik Tiger, Kristina Eriksson, Åsa Rosen, and Bo Jacobsson Disruption of Interleukin-18, but Not Interleukin-1, Increases Vulnerability to Preterm Delivery and Fetal Mortality after Intrauterine Inflammation Am J Pathol 2006 169: 967-976. [Abstract] [Full Text] [PDF]   Nicholas W. Lukacs, Martin L. Moore, Brian D. Rudd, Aaron A. Berlin, Robert D. Collins, Sandra J. Olson, Samuel B. Ho, and R. Stokes Peebles, Jr Differential Immune Responses and Pulmonary Pathophysiology Are Induced by Two Different Strains of Respiratory Syncytial Virus Am J Pathol 2006 169: 977-986. [Abstract] [Full Text] [PDF]   Toshihisa Kawai, Takashi Matsuyama, Yoshitaka Hosokawa, Seicho Makihira, Makoto Seki, Nadeem Y. Karimbux, Reginaldo B. Goncalves, Paloma Valverde, Serge Dibart, Yi-Ping Li, Leticia A. Miranda, Cory W.O. Ernst, Yuichi Izumi, and Martin A. Taubman B and T Lymphocytes Are the Primary Sources of RANKL in the Bone Resorptive Lesion of Periodontal Disease Am J Pathol 2006 169: 987-998. [Abstract] [Full Text] [PDF]   Leah P. Shriver and Bonnie N. Dittel T-Cell-Mediated Disruption of the Neuronal Microtubule Network: Correlation with Early Reversible Axonal Dysfunction in Acute Experimental Autoimmune Encephalomyelitis Am J Pathol 2006 169: 999-1011. [Abstract] [Full Text] [PDF]   Ajaib S. Paintlia, Manjeet K. Paintlia, Inderjit Singh, and Avtar K. Singh Immunomodulatory Effect of Combination Therapy with Lovastatin and 5-Aminoimidazole-4-Carboxamide-1-ß-D-Ribofuranoside Alleviates Neurodegeneration in Experimental Autoimmune Encephalomyelitis Am J Pathol 2006 169: 1012-1025. [Abstract] [Full Text] [PDF]

Neurobiology: Amanda C. Clase, Derek E. Dimcheff, Cynthia Favara, David Dorward, Frank J. McAtee, Lindsay E. Parrie, David Ron, and John L. Portis Oligodendrocytes Are a Major Target of the Toxicity of Spongiogenic Murine Retroviruses Am J Pathol 2006 169: 1026-1038. [Abstract] [Full Text] [PDF] Supplemental Material   Fei Qiao, Carl Atkinson, Hongbin Song, Ravinder Pannu, Inderjit Singh, and Stephen Tomlinson Complement Plays an Important Role in Spinal Cord Injury and Represents a Therapeutic Target for Improving Recovery following Trauma Am J Pathol 2006 169: 1039-1047. [Abstract] [Full Text] [PDF]   R. Lyle Patton, Walter M. Kalback, Chera L. Esh, Tyler A. Kokjohn, Gregory D. Van Vickle, Dean C. Luehrs, Yu-Min Kuo, John Lopez, Daniel Brune, Isidro Ferrer, Eliezer Masliah, Amanda J. Newel, Thomas G. Beach, Eduardo M. Castaño, and Alex E. Roher Amyloid-ß Peptide Remnants in AN-1792-Immunized Alzheimer’s Disease Patients: A Biochemical Analysis Am J Pathol 2006 169: 1048-1063. [Abstract] [Full Text] [PDF] Supplemental Material

Tumorigenesis and Neoplastic Progression: Kerstin Schlüter, Peter Gassmann, Andreas Enns, Timo Korb, Andre Hemping-Bovenkerk, Jens Hölzen, and Jörg Haier Organ-Specific Metastatic Tumor Cell Adhesion and Extravasation of Colon Carcinoma Cells with Different Metastatic Potential Am J Pathol 2006 169: 1064-1073. [Abstract] [Full Text] [PDF] Supplemental Material   Nicole M.R. Schmitz, Andreas Hirt, Markus Aebi, and Kurt Leibundgut Limited Redundancy in Phosphorylation of Retinoblastoma Tumor Suppressor Protein by Cyclin-Dependent Kinases in Acute Lymphoblastic Leukemia Am J Pathol 2006 169: 1074-1079. [Abstract] [Full Text] [PDF]

Vascular Biology, Atherosclerosis and Endothelium Biology: Anne Saaristo, Tuomas Tammela, Anniina Farkkila, Marika Kärkkäinen, Erkki Suominen, Seppo Yla-Herttuala, and Kari Alitalo Vascular Endothelial Growth Factor-C Accelerates Diabetic Wound Healing Am J Pathol 2006 169: 1080-1087. [Abstract] [Full Text] [PDF] Supplemental Material   Elisabeth Naschberger, Clara Lubeseder-Martellato, Nadine Meyer, Ruth Gessner, Elisabeth Kremmer, Andrè Gessner, and Michael Stürzl Human Guanylate Binding Protein-1 Is a Secreted GTPase Present in Increased Concentrations in the Cerebrospinal Fluid of Patients with Bacterial Meningitis Am J Pathol 2006 169: 1088-1099. [Abstract] [Full Text] [PDF]

Correspondence: Michael Eisenhut;, Robert H. Pierce, Noelle K. Polakos, John J. Treanor, I. Nicholas Crispe, David J. Topham, and David H. Adams Ischemic Hepatitis and Collateral Damage to the Liver in Severe Viral Respiratory Tract Infections Am J Pathol 2006 169: 1100. [Full Text] [PDF]

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