On the Cover: Beta-site APP cleaving enzyme (BACE1) is upregulated in aged β-amyloid precursor protein (APP) mouse brain but not in mice lacking interferon (IFN)-γ receptor type I. BACE1 immunoreactivity localized to neurons surrounding Aβ plaques as observed by merged confocal imaging (foreground) of APP mouse brain sections triple stained with antibodies to BACE (green), NeuN (for neuronal staining, red), and Aβ plaques (Congo red analog FSB, blue). (see page 680)

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