In Memoriam: Godfrey S. Getz Robert William Wissler, M.D., Ph.D. (1917–2006) Am J Pathol 2007 170: 791-792. [Full Text] [PDF]

Reviews: James E. Talmadge, Rakesh K. Singh, Isaiah J. Fidler, and Avraham Raz Murine Models to Evaluate Novel and Conventional Therapeutic Strategies for Cancer Am J Pathol 2007 170: 793-804. [Abstract] [Full Text] [PDF]

Commentaries: Parth Patwari and Richard T. Lee Thioredoxins, Mitochondria, and Hypertension Am J Pathol 2007 170: 805-808. [Abstract] [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Hazem Abdul-Hussien, Ratna G.V. Soekhoe, Ekkehard Weber, Jan H. von der Thüsen, Robert Kleemann, Adri Mulder, J. Hajo van Bockel, Roeland Hanemaaijer, and Jan H.N. Lindeman Collagen Degradation in the Abdominal Aneurysm: A Conspiracy of Matrix Metalloproteinase and Cysteine Collagenases Am J Pathol 2007 170: 809-817. [Abstract] [Full Text] [PDF]   Machteld J. van Amerongen, Martin C. Harmsen, Nico van Rooijen, Arjen H. Petersen, and Marja J.A. van Luyn Macrophage Depletion Impairs Wound Healing and Increases Left Ventricular Remodeling after Myocardial Injury in Mice Am J Pathol 2007 170: 818-829. [Abstract] [Full Text] [PDF]   Wanja Michael Bernhardt, Michael Sean Wiesener, Alexander Weidemann, Roland Schmitt, Wilko Weichert, Philipp Lechler, Valentina Campean, Albert Chee Meng Ong, Carsten Willam, Norbert Gretz, and Kai-Uwe Eckardt Involvement of Hypoxia-Inducible Transcription Factors in Polycystic Kidney Disease Am J Pathol 2007 170: 830-842. [Abstract] [Full Text] [PDF]   Yuko Ishida, Akihiko Kimura, Toshikazu Kondo, Takahito Hayashi, Masaya Ueno, Nobuyuki Takakura, Kouji Matsushima, and Naofumi Mukaida Essential Roles of the CC Chemokine Ligand 3-CC Chemokine Receptor 5 Axis in Bleomycin-Induced Pulmonary Fibrosis through Regulation of Macrophage and Fibrocyte Infiltration Am J Pathol 2007 170: 843-854. [Abstract] [Full Text] [PDF]   Thomas H. Thatcher, Sanjay B. Maggirwar, Carolyn J. Baglole, Heather F. Lakatos, Thomas A. Gasiewicz, Richard P. Phipps, and Patricia J. Sime Aryl Hydrocarbon Receptor-Deficient Mice Develop Heightened Inflammatory Responses to Cigarette Smoke and Endotoxin Associated with Rapid Loss of the Nuclear Factor-B Component RelB Am J Pathol 2007 170: 855-864. [Abstract] [Full Text] [PDF]   Seyed H. Hosseini, James J. Kohler, Chad P. Haase, Nina Tioleco, Tami Stuart, Erin Keebaugh, Tomika Ludaway, Rodney Russ, Elgin Green, Robert Long, Liya Wang, Staffan Eriksson, and William Lewis Targeted Transgenic Overexpression of Mitochondrial Thymidine Kinase (TK2) Alters Mitochondrial DNA (mtDNA) and Mitochondrial Polypeptide Abundance: Transgenic TK2, mtDNA, and Antiretrovirals Am J Pathol 2007 170: 865-874. [Abstract] [Full Text] [PDF]

Cell Injury, Repair, Aging and Apoptosis: Yujiang Fang, Yongzhong Wei, Vincent DeMarco, Kemin Chen, Gordon C. Sharp, and Helen Braley-Mullen Murine FLIP Transgene Expressed on Thyroid Epithelial Cells Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis in DBA/1 Mice Am J Pathol 2007 170: 875-887. [Abstract] [Full Text] [PDF]   Daisuke Fukuhara, Yoshikatsu Kanai, Arthit Chairoungdua, Ellappan Babu, Fumio Bessho, Toshio Kawano, Yoshihiro Akimoto, Hitoshi Endou, and Kunimasa Yan Protein Characterization of Na+-Independent System L Amino Acid Transporter 3 in Mice: A Potential Role in Supply of Branched-Chain Amino Acids under Nutrient Starvation Am J Pathol 2007 170: 888-898. [Abstract] [Full Text] [PDF]   YanHe Lue, Krista Erkkila, Peter Y. Liu, Kimberley Ma, Christina Wang, Amiya Sinha Hikim, and Ronald S. Swerdloff Fate of Bone Marrow Stem Cells Transplanted into the Testis: Potential Implication for Men with Testicular Failure Am J Pathol 2007 170: 899-908. [Abstract] [Full Text] [PDF]   Louiza Belkacemi, Shannon A. Bainbridge, Michelle A. Dickinson, Graeme N. Smith, and Charles H. Graham Glyceryl Trinitrate Inhibits Hypoxia/Reoxygenation-Induced Apoptosis in the Syncytiotrophoblast of the Human Placenta: Therapeutic Implications for Preeclampsia Am J Pathol 2007 170: 909-920. [Abstract] [Full Text] [PDF]   Jacques Boddaert, Kiyoka Kinugawa, Jean-Charles Lambert, Fatiha Boukhtouche, Joffrey Zoll, Régine Merval, Olivier Blanc-Brude, David Mann, Claudine Berr, José Vilar, Béatrice Garabedian, Nathalie Journiac, Dominique Charue, Jean-Sébastien Silvestre, Charles Duyckaerts, Philippe Amouyel, Jean Mariani, Alain Tedgui, and Ziad Mallat Evidence of a Role for Lactadherin in Alzheimer’s Disease Am J Pathol 2007 170: 921-929. [Abstract] [Full Text] [PDF] Supplemental Material   Naohiko Shimoda, Nobuyuki Fukazawa, Katsuya Nonomura, and Robert L. Fairchild Cathepsin G Is Required for Sustained Inflammation and Tissue Injury after Reperfusion of Ischemic Kidneys Am J Pathol 2007 170: 930-940. [Abstract] [Full Text] [PDF]

Epithelial and Mesenchymal Cell Biology: Rossa W.K. Chiu, Stephen S.C. Chim, Ivy H.N. Wong, Cesar S.C. Wong, Wing-Shan Lee, Ka F. To, Joanna H.M. Tong, Ryan K.C. Yuen, Alisa S.W. Shum, John K.C. Chan, Lisa Y.S. Chan, Jessie W.F. Yuen, Yu K. Tong, Jingly F. Weier, Christy Ferlatte, Tse N. Leung, Tze K. Lau, Kwok W. Lo, and Y.M. Dennis Lo Hypermethylation of RASSF1A in Human and Rhesus Placentas Am J Pathol 2007 170: 941-950. [Abstract] [Full Text] [PDF] Supplemental Material   Brian A. Babbin, Charles A. Parkos, Kenneth J. Mandell, L. Matthew Winfree, Oskar Laur, Andrei I. Ivanov, and Asma Nusrat Annexin 2 Regulates Intestinal Epithelial Cell Spreading and Wound Closure through Rho-Related Signaling Am J Pathol 2007 170: 951-966. [Abstract] [Full Text] [PDF]

Gastrointestinal, Hepatobiliary and Pancreatic Pathology: Kohji Otogawa, Kohji Kinoshita, Hideki Fujii, Masahide Sakabe, Ryoko Shiga, Kazuki Nakatani, Kazuo Ikeda, Yuji Nakajima, Yoshihiro Ikura, Makiko Ueda, Tetsuo Arakawa, Fumihiko Hato, and Norifumi Kawada Erythrophagocytosis by Liver Macrophages (Kupffer Cells) Promotes Oxidative Stress, Inflammation, and Fibrosis in a Rabbit Model of Steatohepatitis: Implications for the Pathogenesis of Human Nonalcoholic Steatohepatitis Am J Pathol 2007 170: 967-980. [Abstract] [Full Text] [PDF] Supplemental Material   Jolanta Kowalewska, Anja S. Mühlfeld, Kelly L. Hudkins, Matthew M. Yeh, Andrew G. Farr, Jeffrey V. Ravetch, and Charles E. Alpers Thymic Stromal Lymphopoietin Transgenic Mice Develop Cryoglobulinemia and Hepatitis with Similarities to Human Hepatitis C Liver Disease Am J Pathol 2007 170: 981-989. [Abstract] [Full Text] [PDF]

Immunopathology and Infectious Disease: Martina Deckert, Simona Virna, Monika Sakowicz-Burkiewicz, Sonja Lütjen, Sabine Soltek, Horst Bluethmann, and Dirk Schlüter Interleukin-1 Receptor Type 1 Is Essential for Control of Cerebral but Not Systemic Listeriosis Am J Pathol 2007 170: 990-1002. [Abstract] [Full Text] [PDF]   Blandine Geny, Huot Khun, Catherine Fitting, Leticia Zarantonelli, Christelle Mazuet, Nadège Cayet, Marek Szatanik, Marie-Christine Prevost, Jean-Marc Cavaillon, Michel Huerre, and Michel R. Popoff Clostridium sordellii Lethal Toxin Kills Mice by Inducing a Major Increase in Lung Vascular Permeability Am J Pathol 2007 170: 1003-1017. [Abstract] [Full Text] [PDF]   Lucia Mancini, Mark J. Paul-Clark, Guglielmo Rosignoli, Robert Hannon, Jo E. Martin, Ian Macintyre, and Mauro Perretti Calcitonin and Prednisolone Display Antagonistic Actions on Bone and Have Synergistic Effects in Experimental Arthritis Am J Pathol 2007 170: 1018-1027. [Abstract] [Full Text] [PDF]   Gwo-Hsiao Chen, Michal A. Olszewski, Roderick A. McDonald, Jason C. Wells, Robert Paine, III, Gary B. Huffnagle, and Galen B. Toews Role of Granulocyte Macrophage Colony-Stimulating Factor in Host Defense Against Pulmonary Cryptococcus neoformans Infection during Murine Allergic Bronchopulmonary Mycosis Am J Pathol 2007 170: 1028-1040. [Abstract] [Full Text] [PDF]   Jens van den Brandt, Fred Lühder, Kirsty G. McPherson, Katrien L. de Graaf, Denise Tischner, Stefan Wiehr, Thomas Herrmann, Robert Weissert, Ralf Gold, and Holger M. Reichardt Enhanced Glucocorticoid Receptor Signaling in T Cells Impacts Thymocyte Apoptosis and Adaptive Immune Responses Am J Pathol 2007 170: 1041-1053. [Abstract] [Full Text] [PDF]

Tumorigenesis and Neoplastic Progression: Neveen Said, Ida Najwer, and Kouros Motamed Secreted Protein Acidic and Rich in Cysteine (SPARC) Inhibits Integrin-Mediated Adhesion and Growth Factor-Dependent Survival Signaling in Ovarian Cancer Am J Pathol 2007 170: 1054-1063. [Abstract] [Full Text] [PDF] Supplemental Material   Andrea Sadlonova, Shibani Mukherjee, Damon B. Bowe, Sandra R. Gault, Nicole A. Dumas, Brian A. Van Tine, Natalya Frolova, Grier P. Page, Danny R. Welch, Lea Novak, and Andra R. Frost Human Breast Fibroblasts Inhibit Growth of the MCF10AT Xenograft Model of Proliferative Breast Disease Am J Pathol 2007 170: 1064-1076. [Abstract] [Full Text] [PDF]   María Virtudes Céspedes, Carolina Espina, Miguel Angel García-Cabezas, Manuel Trias, Alicia Boluda, María Teresa Gómez del Pulgar, Francesc Josep Sancho, Manuel Nistal, Juan Carlos Lacal, and Ramon Mangues Orthotopic Microinjection of Human Colon Cancer Cells in Nude Mice Induces Tumor Foci in All Clinically Relevant Metastatic Sites Am J Pathol 2007 170: 1077-1085. [Abstract] [Full Text] [PDF]   Hiroshi Koyama, Terumasa Hibi, Zenzo Isogai, Masahiko Yoneda, Minoru Fujimori, Jun Amano, Masatomo Kawakubo, Reiji Kannagi, Koji Kimata, Shun’ichiro Taniguchi, and Naoki Itano Hyperproduction of Hyaluronan in Neu-Induced Mammary Tumor Accelerates Angiogenesis through Stromal Cell Recruitment: Possible Involvement of Versican/PG-M Am J Pathol 2007 170: 1086-1099. [Abstract] [Full Text] [PDF]

Vascular Biology, Atherosclerosis and Endothelium Biology: Paul A. VanderLaan, Catherine A. Reardon, Yuval Sagiv, Lydia Blachowicz, John Lukens, Michael Nissenbaum, Chyung-Ru Wang, and Godfrey S. Getz Characterization of the Natural Killer T-Cell Response in an Adoptive Transfer Model of Atherosclerosis Am J Pathol 2007 170: 1100-1107. [Abstract] [Full Text] [PDF]   Haifeng Zhang, Yan Luo, Wei Zhang, Yun He, Shengchuan Dai, Rong Zhang, Yan Huang, Pascal Bernatchez, Frank J. Giordano, Gerald Shadel, William C. Sessa, and Wang Min Endothelial-Specific Expression of Mitochondrial Thioredoxin Improves Endothelial Cell Function and Reduces Atherosclerotic Lesions Am J Pathol 2007 170: 1108-1120. [Abstract] [Full Text] [PDF] Supplemental Material   Jennifer A. Ralph, Davide Zocco, Barry Bresnihan, Oliver FitzGerald, Alice N. McEvoy, and Evelyn P. Murphy A Role for Type 1 Corticotropin-Releasing Hormone Receptors in Mediating Local Changes in Chronically Inflamed Tissue Am J Pathol 2007 170: 1121-1133. [Abstract] [Full Text] [PDF]

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