Biological Perspectives: Daniel G. Remick Pathophysiology of Sepsis Am J Pathol 2007 170: 1435-1444. [Abstract] [Full Text] [PDF]

Reviews: Hiroko Ohgaki and Paul Kleihues Genetic Pathways to Primary and Secondary Glioblastoma Am J Pathol 2007 170: 1445-1453. [Abstract] [Full Text] [PDF]

Commentaries: Gavin P. Robertson Mig-7 Linked to Vasculogenic Mimicry Am J Pathol 2007 170: 1454-1456. [Full Text] [PDF]   Xiongwei Zhu, Jesus Avila, George Perry, and Mark A. Smith Treating the Lesions, Not the Disease Am J Pathol 2007 170: 1457-1459. [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Lieve Umans, Luk Cox, Marc Tjwa, Virginie Bito, Liesbeth Vermeire, Kjell Laperre, Karin Sipido, Lieve Moons, Danny Huylebroeck, and An Zwijsen Inactivation of Smad5 in Endothelial Cells and Smooth Muscle Cells Demonstrates that Smad5 Is Required for Cardiac Homeostasis Am J Pathol 2007 170: 1460-1472. [Abstract] [Full Text] [PDF]   Yukiko Kanetsuna, Keiko Takahashi, Michio Nagata, Maureen A. Gannon, Matthew D. Breyer, Raymond C. Harris, and Takamune Takahashi Deficiency of Endothelial Nitric-Oxide Synthase Confers Susceptibility to Diabetic Nephropathy in Nephropathy-Resistant Inbred Mice Am J Pathol 2007 170: 1473-1484. [Abstract] [Full Text] [PDF] Supplemental Material   Gabriela E. Garcia, Luan D. Truong, Ping Li, Ping Zhang, Richard J. Johnson, Curtis B. Wilson, and Lili Feng Inhibition of CXCL16 Attenuates Inflammatory and Progressive Phases of Anti-Glomerular Basement Membrane Antibody-Associated Glomerulonephritis Am J Pathol 2007 170: 1485-1496. [Abstract] [Full Text] [PDF] Supplemental Material

Cell Injury, Repair, Aging and Apoptosis: John Wong, Veselina Korcheva, David B. Jacoby, and Bruce Magun Intrapulmonary Delivery of Ricin at High Dosage Triggers a Systemic Inflammatory Response and Glomerular Damage Am J Pathol 2007 170: 1497-1510. [Abstract] [Full Text] [PDF] Supplemental Material   Tereza Cindrova-Davies, Olivera Spasic-Boskovic, Eric Jauniaux, D. Stephen Charnock-Jones, and Graham J. Burton Nuclear Factor-B, p38, and Stress-Activated Protein Kinase Mitogen-Activated Protein Kinase Signaling Pathways Regulate Proinflammatory Cytokines and Apoptosis in Human Placental Explants in Response to Oxidative Stress: Effects of Antioxidant Vitamins Am J Pathol 2007 170: 1511-1520. [Abstract] [Full Text] [PDF]   Yang Cao, Sharmila Adhikari, Marie Véronique Clément, Matthew Wallig, and Madhav Bhatia Induction of Apoptosis by Crambene Protects Mice against Acute Pancreatitis via Anti-Inflammatory Pathways Am J Pathol 2007 170: 1521-1534. [Abstract] [Full Text] [PDF]

Epithelial and Mesenchymal Cell Biology: Chun-Hui Yi, David J. Smith, William W. West, and Michael A. Hollingsworth Loss of Fibulin-2 Expression Is Associated with Breast Cancer Progression Am J Pathol 2007 170: 1535-1545. [Abstract] [Full Text] [PDF] Supplemental Material   Malathy P.V. Shekhar, Steven Santner, Kathryn A. Carolin, and Larry Tait Direct Involvement of Breast Tumor Fibroblasts in the Modulation of Tamoxifen Sensitivity Am J Pathol 2007 170: 1546-1560. [Abstract] [Full Text] [PDF]   Alexandra Rolaki, George Coukos, Dimitris Loutradis, Horace M. DeLisser, Christos Coutifaris, and Antonis Makrigiannakis Luteogenic Hormones Act through a Vascular Endothelial Growth Factor-Dependent Mechanism to Up-Regulate 5ß1 and vß3 Integrins, Promoting the Migration and Survival of Human Luteinized Granulosa Cells Am J Pathol 2007 170: 1561-1572. [Abstract] [Full Text] [PDF]

Growth Factors, Cytokines, Cell Cycle Molecules: Elena Ortiz-Zapater, Sandra Peiró, Oriol Roda, Josep M. Corominas, Susana Aguilar, Coral Ampurdanés, Francisco X. Real, and Pilar Navarro Tissue Plasminogen Activator Induces Pancreatic Cancer Cell Proliferation by a Non-Catalytic Mechanism That Requires Extracellular Signal-Regulated Kinase 1/2 Activation through Epidermal Growth Factor Receptor and Annexin A2 Am J Pathol 2007 170: 1573-1584. [Abstract] [Full Text] [PDF]   Agoston T. Agoston, Pedram Argani, Angelo M. De Marzo, Jessica L. Hicks, and William G. Nelson Retinoblastoma Pathway Dysregulation Causes DNA Methyltransferase 1 Overexpression in Cancer via MAD2-Mediated Inhibition of the Anaphase-Promoting Complex Am J Pathol 2007 170: 1585-1593. [Abstract] [Full Text] [PDF]   Fumikata Hara, Shaija Samuel, Jinsong Liu, Daniel Rosen, Robert R. Langley, and Honami Naora A Homeobox Gene Related to Drosophila Distal-Less Promotes Ovarian Tumorigenicity by Inducing Expression of Vascular Endothelial Growth Factor and Fibroblast Growth Factor-2 Am J Pathol 2007 170: 1594-1606. [Abstract] [Full Text] [PDF]   Huai-Chia Chuang, Jong-Ding Lay, Shuang-En Chuang, Wen-Chuan Hsieh, Yao Chang, and Ih-Jen Su Epstein-Barr Virus (EBV) Latent Membrane Protein-1 Down-Regulates Tumor Necrosis Factor- (TNF-) Receptor-1 and Confers Resistance to TNF--Induced Apoptosis in T Cells: Implication for the Progression to T-Cell Lymphoma in EBV-Associated Hemophagocytic Syndrome Am J Pathol 2007 170: 1607-1617. [Abstract] [Full Text] [PDF]   Xuegong Zhu, Katie Lee, Sylvia L. Asa, and Shereen Ezzat Epigenetic Silencing through DNA and Histone Methylation of Fibroblast Growth Factor Receptor 2 in Neoplastic Pituitary Cells Am J Pathol 2007 170: 1618-1628. [Abstract] [Full Text] [PDF]

Immunopathology and Infectious Disease: Wen-Chuan Hsieh, Yao Chang, Mei-Chi Hsu, Bau-Shin Lan, Guan-Chung Hsiao, Huai-Chia Chuang, and Ih-Jen Su Emergence of Anti-Red Blood Cell Antibodies Triggers Red Cell Phagocytosis by Activated Macrophages in a Rabbit Model of Epstein-Barr Virus-Associated Hemophagocytic Syndrome Am J Pathol 2007 170: 1629-1639. [Abstract] [Full Text] [PDF]   Dieudonnée Togbe, Louis Schofield, Georges E. Grau, Bruno Schnyder, Victorine Boissay, Sabine Charron, Stéphanie Rose, Bruce Beutler, Valérie F.J. Quesniaux, and Bernhard Ryffel Murine Cerebral Malaria Development Is Independent of Toll-Like Receptor Signaling Am J Pathol 2007 170: 1640-1648. [Abstract] [Full Text] [PDF] Supplemental Material   Tomoyuki Fujita, Manabu Fujimoto, Takashi Matsushita, Yuka Shimada, Minoru Hasegawa, Yoshihiro Kuwano, Fumihide Ogawa, Kazuhiko Takehara, and Shinichi Sato Phase-Dependent Roles of E-Selectin during Chronic Contact Hypersensitivity Responses Am J Pathol 2007 170: 1649-1658. [Abstract] [Full Text] [PDF]

Molecular Pathogenesis of Genetic and Inherited Diseases: Belén Prados, Almudena Peña, Rocío P. Cotarelo, M. Carmen Valero, and Jesús Cruces Expression of the Murine Pomt1 Gene in Both the Developing Brain and Adult Muscle Tissues and Its Relationship with Clinical Aspects of Walker-Warburg Syndrome Am J Pathol 2007 170: 1659-1668. [Abstract] [Full Text] [PDF] Supplemental Material   Antonella Caccamo, Salvatore Oddo, Lana X. Tran, and Frank M. LaFerla Lithium Reduces Tau Phosphorylation but Not Aß or Working Memory Deficits in a Transgenic Model with Both Plaques and Tangles Am J Pathol 2007 170: 1669-1678. [Abstract] [Full Text] [PDF]

Musculoskeletal Pathology: Didier Merciris, Caroline Marty, Corinne Collet, Marie-Christine de Vernejoul, and Valerie Geoffroy Overexpression of the Transcriptional Factor Runx2 in Osteoblasts Abolishes the Anabolic Effect of Parathyroid Hormone in Vivo Am J Pathol 2007 170: 1676-1685. [Abstract] [Full Text] [PDF]   Frank Baliko, Tamara Bright, Raymond Poon, Brenda Cohen, Sean E. Egan, and Benjamin A. Alman Inhibition of Notch Signaling Induces Neural Differentiation in Ewing Sarcoma Am J Pathol 2007 170: 1686-1694. [Abstract] [Full Text] [PDF]

Neurobiology: Tanuja Chitnis, Jaime Imitola, Yue Wang, Wassim Elyaman, Prianka Chawla, Maia Sharuk, Khadir Raddassi, Roderick T. Bronson, and Samia J. Khoury Elevated Neuronal Expression of CD200 Protects Wlds Mice from Inflammation-Mediated Neurodegeneration Am J Pathol 2007 170: 1695-1712. [Abstract] [Full Text] [PDF]   Leah T. Remington, Alicia A. Babcock, Simone P. Zehntner, and Trevor Owens Microglial Recruitment, Activation, and Proliferation in Response to Primary Demyelination Am J Pathol 2007 170: 1713-1724. [Abstract] [Full Text] [PDF]   Brian M. Dufty, Lisa R. Warner, Sheng T. Hou, Susan X. Jiang, Teresa Gomez-Isla, Kristen M. Leenhouts, Julia T. Oxford, Mel B. Feany, Eliezer Masliah, and Troy T. Rohn Calpain-Cleavage of -Synuclein: Connecting Proteolytic Processing to Disease-Linked Aggregation Am J Pathol 2007 170: 1725-1738. [Abstract] [Full Text] [PDF] Supplemental Material

Tumorigenesis and Neoplastic Progression: Tone Sandal, Klara Valyi-Nagy, Virginia A. Spencer, Robert Folberg, Mina J. Bissell, and Andrew J. Maniotis Epigenetic Reversion of Breast Carcinoma Phenotype Is Accompanied by Changes in DNA Sequestration as Measured by AluI Restriction Enzyme Am J Pathol 2007 170: 1739-1749. [Abstract] [Full Text] [PDF]   Yoh Zen, Takahiko Fujii, Seiichi Yoshikawa, Hiroyuki Takamura, Takashi Tani, Tetsuo Ohta, and Yasuni Nakanuma Histological and Culture Studies with Respect to ABCG2 Expression Support the Existence of a Cancer Cell Hierarchy in Human Hepatocellular Carcinoma Am J Pathol 2007 170: 1750-1762. [Abstract] [Full Text] [PDF]   Aaron P. Petty, Kiera L. Garman, Virginia D. Winn, Celee M. Spidel, and J. Suzanne Lindsey Overexpression of Carcinoma and Embryonic Cytotrophoblast Cell-Specific Mig-7 Induces Invasion and Vessel-Like Structure Formation Am J Pathol 2007 170: 1763-1780. [Abstract] [Full Text] [PDF] Supplemental Material   Patrick Auguste, Lucia Fallavollita, Ni Wang, Julia Burnier, Andreas Bikfalvi, and Pnina Brodt The Host Inflammatory Response Promotes Liver Metastasis by Increasing Tumor Cell Arrest and Extravasation Am J Pathol 2007 170: 1781-1792. [Abstract] [Full Text] [PDF] Supplemental Material   Norman L. Lehman, Rob Tibshirani, Jerry Y. Hsu, Yasodha Natkunam, Brent T. Harris, Robert B. West, Marilyn A. Masek, Kelli Montgomery, Matt van de Rijn, and Peter K. Jackson Oncogenic Regulators and Substrates of the Anaphase Promoting Complex/Cyclosome Are Frequently Overexpressed in Malignant Tumors Am J Pathol 2007 170: 1793-1805. [Abstract] [Full Text] [PDF] Supplemental Material

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