Editorials: Jay M. McDonald, Maria Giorla Eisemann, and Audra E. Cox A Matter of Trust: Introducing the Journal Scientific Integrity Policy Am J Pathol 2007 171: 1. First published online May 24, 2007; doi:10.2353/ajpath.2007.070458 [Full Text] [PDF]

Biological Perspectives: Lars-Peter Erwig and Peter M. Henson Immunological Consequences of Apoptotic Cell Phagocytosis Am J Pathol 2007 171: 2-8. First published online May 18, 2007; doi:10.2353/ajpath.2007.070135 [Abstract] [Full Text] [PDF]

Commentaries: Yashpal S. Kanwar, Farhad R. Danesh, and Sumant S. Chugh Contribution of Proteoglycans Towards the Integrated Functions of Renal Glomerular Capillaries: A Historical Perspective Am J Pathol 2007 171: 9-13. First published online May 18, 2007; doi:10.2353/ajpath.2007.070356 [Full Text] [PDF]   Patricia A. D’Amore Vascular Endothelial Cell Growth Factor-A: Not Just for Endothelial Cells Anymore Am J Pathol 2007 171: 14-18. First published online May 18, 2007; doi:10.2353/ajpath.2007.070385 [Full Text] [PDF]

Regular Articles:

Epithelial and Mesenchymal Cell Biology: Ralph Brehm, Martina Zeiler, Christina Rüttinger, Katja Herde, Mark Kibschull, Elke Winterhager, Klaus Willecke, Florian Guillou, Charlotte Lécureuil, Klaus Steger, Lutz Konrad, Katharina Biermann, Klaus Failing, and Martin Bergmann A Sertoli Cell-Specific Knockout of Connexin43 Prevents Initiation of Spermatogenesis Am J Pathol 2007 171: 19-31. First published online May 10, 2007; doi:10.2353/ajpath.2007.061171 [Abstract] [Full Text] [PDF]   John B. Mee, Claire M. Johnson, Nilesh Morar, Frank Burslem, and Richard W. Groves The Psoriatic Transcriptome Closely Resembles That Induced by Interleukin-1 in Cultured Keratinocytes: Dominance of Innate Immune Responses in Psoriasis Am J Pathol 2007 171: 32-42. First published online May 31, 2007; doi:10.2353/ajpath.2007.061067 [Abstract] [Full Text] [PDF] Supplemental Material   Yasuko Yamanaka, Masashi Akiyama, Yoriko Sugiyama-Nakagiri, Kaori Sakai, Maki Goto, James R. McMillan, Mitsuhito Ota, Daisuke Sawamura, and Hiroshi Shimizu Expression of the Keratinocyte Lipid Transporter ABCA12 in Developing and Reconstituted Human Epidermis Am J Pathol 2007 171: 43-52. First published online May 10, 2007; doi:10.2353/ajpath.2007.061207 [Abstract] [Full Text] [PDF]

Growth Factors, Cytokines, Cell Cycle Molecules: Kazuaki Nishijima, Yin-Shan Ng, Lichun Zhong, John Bradley, William Schubert, Nobuo Jo, Jo Akita, Steven J. Samuelsson, Gregory S. Robinson, Anthony P. Adamis, and David T. Shima Vascular Endothelial Growth Factor-A Is a Survival Factor for Retinal Neurons and a Critical Neuroprotectant during the Adaptive Response to Ischemic Injury Am J Pathol 2007 171: 53-67. First published online April 26, 2007; doi:10.2353/ajpath.2007.061237 [Abstract] [Full Text] [PDF] Supplemental Material   Masamitsu Tanaka, Reiko Kamata, Misato Takigahira, Kazuyoshi Yanagihara, and Ryuichi Sakai Phosphorylation of Ephrin-B1 Regulates Dissemination of Gastric Scirrhous Carcinoma Am J Pathol 2007 171: 68-78. First published online May 24, 2007; doi:10.2353/ajpath.2007.070033 [Abstract] [Full Text] [PDF] Supplemental Material

Immunopathology and Infectious Disease: Gabriel Melo de Oliveira, Rafaela Lopes Diniz, Wanderson Batista, Marcelo Meuser Batista, Cristiane Bani Correa, Tânia Cremonini de Araújo-Jorge, and Andréa Henriques-Pons Fas Ligand-Dependent Inflammatory Regulation in Acute Myocarditis Induced by Trypanosoma cruzi Infection Am J Pathol 2007 171: 79-86. First published online May 10, 2007; doi:10.2353/ajpath.2007.060643 [Abstract] [Full Text] [PDF]   Doreen E. Wesche-Soldato, Chun-Shiang Chung, Stephen H. Gregory, Thais P. Salazar-Mather, Carol A. Ayala, and Alfred Ayala CD8+ T Cells Promote Inflammation and Apoptosis in the Liver after Sepsis: Role of Fas-FasL Am J Pathol 2007 171: 87-96. First published online May 3, 2007; doi:10.2353/ajpath.2007.061099 [Abstract] [Full Text] [PDF]   Abdiaziz S. Mohamood, Mehmet L. Guler, Zuoxiang Xiao, Dongfeng Zheng, Allan Hess, Yi Wang, Hideo Yagita, Jonathan P. Schneck, and Abdel Rahim A. Hamad Protection from Autoimmune Diabetes and T-Cell Lymphoproliferation Induced by FasL Mutation Are Differentially Regulated and Can Be Uncoupled Pharmacologically Am J Pathol 2007 171: 97-106. First published online May 18, 2007; doi:10.2353/ajpath.2007.070148 [Abstract] [Full Text] [PDF]   Ann-Kristin Mueller, Martina Deckert, Kirsten Heiss, Kristin Goetz, Kai Matuschewski, and Dirk Schlüter Genetically Attenuated Plasmodium berghei Liver Stages Persist and Elicit Sterile Protection Primarily via CD8 T Cells Am J Pathol 2007 171: 107-115. First published online May 18, 2007; doi:10.2353/ajpath.2007.060792 [Abstract] [Full Text] [PDF]

Matrix Pathobiology: Agneta Simionescu, Dan T. Simionescu, and Narendra R. Vyavahare Osteogenic Responses in Fibroblasts Activated by Elastin Degradation Products and Transforming Growth Factor-ß1: Role of Myofibroblasts in Vascular Calcification Am J Pathol 2007 171: 116-123. First published online May 10, 2007; doi:10.2353/ajpath.2007.060930 [Abstract] [Full Text] [PDF]   Vanessa M. Freitas, Vanessa F. Vilas-Boas, Daniel C. Pimenta, Vania Loureiro, Maria A. Juliano, Márcia R. Carvalho, João J.V. Pinheiro, Antonio C.M. Camargo, Anselmo S. Moriscot, Matthew P. Hoffman, and Ruy G. Jaeger SIKVAV, a Laminin 1-Derived Peptide, Interacts with Integrins and Increases Protease Activity of a Human Salivary Gland Adenoid Cystic Carcinoma Cell Line through the ERK 1/2 Signaling Pathway Am J Pathol 2007 171: 124-138. First published online May 24, 2007; doi:10.2353/ajpath.2007.051264 [Abstract] [Full Text] [PDF] Supplemental Material   Scott J. Harvey, George Jarad, Jeanette Cunningham, Angelique L. Rops, Johan van der Vlag, Jo H. Berden, Marcus J. Moeller, Lawrence B. Holzman, Robert W. Burgess, and Jeffrey H. Miner Disruption of Glomerular Basement Membrane Charge through Podocyte-Specific Mutation of Agrin Does Not Alter Glomerular Permselectivity Am J Pathol 2007 171: 139-152. First published online May 31, 2007; doi:10.2353/ajpath.2007.061116 [Abstract] [Full Text] [PDF]

Molecular Pathogenesis of Genetic and Inherited Diseases: Wilhelm Stoffel, Britta Jenke, Barbara Holz, Erika Binczek, Robert Heinz Günter, Jutta Knifka, Jürgen Koebke, and Anja Niehoff Neutral Sphingomyelinase (SMPD3) Deficiency Causes a Novel Form of Chondrodysplasia and Dwarfism That Is Rescued by Col2A1-Driven smpd3 Transgene Expression Am J Pathol 2007 171: 153-161. First published online April 26, 2007; doi:10.2353/ajpath.2007.061285 [Abstract] [Full Text] [PDF]   Larissa Lipskaia, Caroline Pinet, Yves Fromes, Stéphane Hatem, Isabelle Cantaloube, Alain Coulombe, and Anne-Marie Lompré Mutation of -Sarcoglycan Is Associated with Ca2+-Dependent Vascular Remodeling in the Syrian Hamster Am J Pathol 2007 171: 162-171. First published online May 3, 2007; doi:10.2353/ajpath.2007.070054 [Abstract] [Full Text] [PDF]   Jingmin Yan, Xiaoying Fu, Fengxia Ge, Beiru Zhang, Junjie Yao, Huanyu Zhang, Jinze Qian, Hiroshi Tomozawa, Hironobu Naiki, Jinko Sawashita, Masayuki Mori, and Keiichi Higuchi Cross-Seeding and Cross-Competition in Mouse Apolipoprotein A-II Amyloid Fibrils and Protein A Amyloid Fibrils Am J Pathol 2007 171: 172-180. First published online May 18, 2007; doi:10.2353/ajpath.2007.060576 [Abstract] [Full Text] [PDF]   Rui Xu, Kumaran Chandrasekharan, Jung Hae Yoon, Marybeth Camboni, and Paul T. Martin Overexpression of the Cytotoxic T Cell (CT) Carbohydrate Inhibits Muscular Dystrophy in the dyW Mouse Model of Congenital Muscular Dystrophy 1A Am J Pathol 2007 171: 181-199. First published online May 10, 2007; doi:10.2353/ajpath.2007.060927 [Abstract] [Full Text] [PDF]

Neurobiology: Uwe Koedel, Ulrike Michaela Merbt, Caroline Schmidt, Barbara Angele, Bernadette Popp, Hermann Wagner, Hans-Walter Pfister, and Carsten J. Kirschning Acute Brain Injury Triggers MyD88-Dependent, TLR2/4-Independent Inflammatory Responses Am J Pathol 2007 171: 200-213. First published online April 26, 2007; doi:10.2353/ajpath.2007.060821 [Abstract] [Full Text] [PDF]   Kazusaku Kamiya, Yoshiaki Fujinami, Noriyuki Hoya, Yasuhide Okamoto, Hiroko Kouike, Rie Komatsuzaki, Ritsuko Kusano, Susumu Nakagawa, Hiroko Satoh, Masato Fujii, and Tatsuo Matsunaga Mesenchymal Stem Cell Transplantation Accelerates Hearing Recovery through the Repair of Injured Cochlear Fibrocytes Am J Pathol 2007 171: 214-226. First published online May 24, 2007; doi:10.2353/ajpath.2007.060948 [Abstract] [Full Text] [PDF]   Nigel J. Cairns, Manuela Neumann, Eileen H. Bigio, Ida E. Holm, Dirk Troost, Kimmo J. Hatanpaa, Chan Foong, Charles L. White, III, Julie A. Schneider, Hans A. Kretzschmar, Deborah Carter, Lisa Taylor-Reinwald, Katherine Paulsmeyer, Jeffrey Strider, Michael Gitcho, Alison M. Goate, John C. Morris, Manjari Mishra, Linda K. Kwong, Anna Stieber, Yan Xu, Mark S. Forman, John Q. Trojanowski, Virginia M.-Y. Lee, and Ian R.A. Mackenzie TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions Am J Pathol 2007 171: 227-240. First published online May 18, 2007; doi:10.2353/ajpath.2007.070182 [Abstract] [Full Text] [PDF] Supplemental Material   Wesley Farris, Sonja G. Schütz, John R. Cirrito, Ganesh M. Shankar, Xiaoyan Sun, Ana George, Malcolm A. Leissring, Dominic M. Walsh, Wei Qiao Qiu, David M. Holtzman, and Dennis J. Selkoe Loss of Neprilysin Function Promotes Amyloid Plaque Formation and Causes Cerebral Amyloid Angiopathy Am J Pathol 2007 171: 241-251. First published online May 18, 2007; doi:10.2353/ajpath.2007.070105 [Abstract] [Full Text] [PDF]

Tumorigenesis and Neoplastic Progression: Sangjun Lee, Dan Medina, Anna Tsimelzon, Syed K. Mohsin, Sufeng Mao, Yun Wu, and D. Craig Allred Alterations of Gene Expression in the Development of Early Hyperplastic Precursors of Breast Cancer Am J Pathol 2007 171: 252-262. First published online May 24, 2007; doi:10.2353/ajpath.2007.061010 [Abstract] [Full Text] [PDF] Supplemental Material   Liqin Zhu, Guanglu Shi, C. Max. Schmidt, Ralph H. Hruban, and Stephen F. Konieczny Acinar Cells Contribute to the Molecular Heterogeneity of Pancreatic Intraepithelial Neoplasia Am J Pathol 2007 171: 263-273. First published online April 26, 2007; doi:10.2353/ajpath.2007.061176 [Abstract] [Full Text] [PDF]   Kozo Hosono, Yoshihiro Nishida, Warren Knudson, Cheryl B. Knudson, Takahiro Naruse, Yoshitaka Suzuki, and Naoki Ishiguro Hyaluronan Oligosaccharides Inhibit Tumorigenicity of Osteosarcoma Cell Lines MG-63 and LM-8 in Vitro and in Vivo via Perturbation of Hyaluronan-Rich Pericellular Matrix of the Cells Am J Pathol 2007 171: 274-286. First published online May 18, 2007; doi:10.2353/ajpath.2007.060828 [Abstract] [Full Text] [PDF]   Weihua Qiu, Bingsen Zhou, Peiguo G. Chu, Frank Luh, and Yun Yen The Induction of Growth Arrest DNA Damage-Inducible Gene 45 ß in Human Hepatoma Cell Lines by S-Adenosylmethionine Am J Pathol 2007 171: 287-296. First published online May 10, 2007; doi:10.2353/ajpath.2007.070121 [Abstract] [Full Text] [PDF]   Chang Tong, Zhinan Yin, Zibo Song, Ashley Dockendorff, Chuanshu Huang, John Mariadason, Richard A. Flavell, Roger J. Davis, Leonard H. Augenlicht, and Wancai Yang c-Jun NH2-Terminal Kinase 1 Plays a Critical Role in Intestinal Homeostasis and Tumor Suppression Am J Pathol 2007 171: 297-303. First published online May 10, 2007; doi:10.2353/ajpath.2007.061036 [Abstract] [Full Text] [PDF]

Vascular Biology, Atherosclerosis and Endothelium Biology: Xinwen Wang, Hong Mu, Hong Chai, Dan Liao, Qizhi Yao, and Changyi Chen Human Immunodeficiency Virus Protease Inhibitor Ritonavir Inhibits Cholesterol Efflux from Human Macrophage-Derived Foam Cells Am J Pathol 2007 171: 304-314. First published online May 3, 2007; doi:10.2353/ajpath.2007.060965 [Abstract] [Full Text] [PDF]   Barbara Coles, Ceri A. Fielding, Stefan Rose-John, Jürgen Scheller, Simon A. Jones, and Valerie B. O’Donnell Classic Interleukin-6 Receptor Signaling and Interleukin-6 trans-Signaling Differentially Control Angiotensin II-Dependent Hypertension, Cardiac Signal Transducer and Activator of Transcription-3 Activation, and Vascular Hypertrophy in Vivo Am J Pathol 2007 171: 315-325. First published online May 3, 2007; doi:10.2353/ajpath.2007.061078 [Abstract] [Full Text] [PDF]   Oscar L. Volger, Joost O. Fledderus, Natasja Kisters, Ruud D. Fontijn, Perry D. Moerland, Johan Kuiper, Theo J. van Berkel, Ann-Pascale J.J. Bijnens, Mat J.A.P. Daemen, Hans Pannekoek, and Anton J.G. Horrevoets Distinctive Expression of Chemokines and Transforming Growth Factor-ß Signaling in Human Arterial Endothelium during Atherosclerosis Am J Pathol 2007 171: 326-337. First published online May 3, 2007; doi:10.2353/ajpath.2007.061196 [Abstract] [Full Text] [PDF] Supplemental Material   Susanne Jackowski, Matthias Janusch, Eckhard Fiedler, Wolfgang C. Marsch, Eva J. Ulbrich, Gabriele Gaisbauer, Jürgen Dunst, Dontscho Kerjaschki, and Peter Helmbold Radiogenic Lymphangiogenesis in the Skin Am J Pathol 2007 171: 338-348. First published online May 31, 2007; doi:10.2353/ajpath.2007.060589 [Abstract] [Full Text] [PDF] Supplemental Material   Joshua M. Astern, William F. Pendergraft, III, Ronald J. Falk, J. Charles Jennette, Alvin H. Schmaier, Fakhri Mahdi, and Gloria A. Preston Myeloperoxidase Interacts with Endothelial Cell-Surface Cytokeratin 1 and Modulates Bradykinin Production by the Plasma Kallikrein-Kinin System Am J Pathol 2007 171: 349-360. First published online May 3, 2007; doi:10.2353/ajpath.2007.060831 [Abstract] [Full Text] [PDF]   Tina Dietrich, Jasmine Onderka, Felix Bock, Friedrich E. Kruse, Dörte Vossmeyer, Roland Stragies, Grit Zahn, and Claus Cursiefen Inhibition of Inflammatory Lymphangiogenesis by Integrin 5 Blockade Am J Pathol 2007 171: 361-372. First published online May 24, 2007; doi:10.2353/ajpath.2007.060896 [Abstract] [Full Text] [PDF]

Correspondence: Daniel Favre and Nelson Fausto Efficiency of Hepatitis C Virus Infection in Vitro Am J Pathol 2007 171: 373. First published online May 18, 2007; doi:10.2353/ajpath.2007.070352 [Full Text] [PDF]

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