On the Cover: Schematic diagram representing the steps involved in miRNA processing and function. Alterations in the amounts of miRNAs and their precursors can result in cancer. In tumorigenesis, excessive accumulation of miRNA that normally regulates synthesis of a tumor suppressor may promote cancer by causing under-expression of the tumor suppressor (left panel). Conversely, underexpression of miRNA that normally controls the expression of a proto-oncogene can lead to excess accumulation of that gene product (right panel). (see page 728).

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