Reviews: Ravinay Bhindi, Roger G. Fahmy, Harry C. Lowe, Colin N. Chesterman, Crispin R. Dass, Murray J. Cairns, Edward G. Saravolac, Lun-Quan Sun, and Levon M. Khachigian Brothers in Arms: DNA Enzymes, Short Interfering RNA, and the Emerging Wave of Small-Molecule Nucleic Acid-Based Gene-Silencing Strategies Am J Pathol 2007 171: 1079-1088. First published online August 23, 2007; doi:10.2353/ajpath.2007.070120 [Abstract] [Full Text] [PDF]

Commentaries: Keith G. Mansfield Viral Tropism and the Pathogenesis of Influenza in the Mammalian Host Am J Pathol 2007 171: 1089-1092. First published online August 23, 2007; doi:10.2353/ajpath.2007.070695 [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Tatsuma Okazaki, Satoru Ebihara, Masanori Asada, Shinsuke Yamanda, Yoshifumi Saijo, Yasuyuki Shiraishi, Takae Ebihara, Kaijun Niu, He Mei, Hiroyuki Arai, and Tomoyuki Yambe Macrophage Colony-Stimulating Factor Improves Cardiac Function after Ischemic Injury by Inducing Vascular Endothelial Growth Factor Production and Survival of Cardiomyocytes Am J Pathol 2007 171: 1093-1103. First published online August 23, 2007; doi:10.2353/ajpath.2007.061191 [Abstract] [Full Text] [PDF]   Matthew J. Socha, Marlina Manhiani, Neveen Said, John D. Imig, and Kouros Motamed Secreted Protein Acidic and Rich in Cysteine Deficiency Ameliorates Renal Inflammation and Fibrosis in Angiotensin Hypertension Am J Pathol 2007 171: 1104-1112. First published online August 23, 2007; doi:10.2353/ajpath.2007.061273 [Abstract] [Full Text] [PDF] Supplemental Material   Huimin Zhang, William E. Lawson, Vasiliy V. Polosukhin, Ambra Pozzi, Timothy S. Blackwell, Ying Litingtung, and Chin Chiang Inhibitor of Differentiation 1 Promotes Endothelial Survival in a Bleomycin Model of Lung Injury in Mice Am J Pathol 2007 171: 1113-1126. First published online August 23, 2007; doi:10.2353/ajpath.2007.070226 [Abstract] [Full Text] [PDF]   Jens Bedke, Eva Kiss, Carl-Ludwig Behnes, Zoran V. Popovic, Markus Heuser, Tomislav Stojanovic, Tjeerd Sijmonsma, Peter Huber, Sophie Domhan, Stefan Muschal, Amir Abdollahi, Norbert Gretz, and Hermann-Josef Gröne Anti-Inflammatory Effects of v Integrin Antagonism in Acute Kidney Allograft Rejection Am J Pathol 2007 171: 1127-1139. First published online August 16, 2007; doi:10.2353/ajpath.2007.070329 [Abstract] [Full Text] [PDF]

Cell Injury, Repair, Aging and Apoptosis: Abelardo Medina, Ruhangiz T. Kilani, Nicholas Carr, Erin Brown, and Aziz Ghahary Transdifferentiation of Peripheral Blood Mononuclear Cells into Epithelial-Like Cells Am J Pathol 2007 171: 1140-1152. First published online August 23, 2007; doi:10.2353/ajpath.2007.070051 [Abstract] [Full Text] [PDF]   Eniko Bodó, Desmond J. Tobin, York Kamenisch, Tamás Bíró, Mark Berneburg, Wolfgang Funk, and Ralf Paus Dissecting the Impact of Chemotherapy on the Human Hair Follicle: A Pragmatic in Vitro Assay for Studying the Pathogenesis and Potential Management of Hair Follicle Dystrophy Am J Pathol 2007 171: 1153-1167. First published online September 6, 2007; doi:10.2353/ajpath.2007.061164 [Abstract] [Full Text] [PDF] Supplemental Material   Tereza Cindrova-Davies, Hong-Wa Yung, Jemma Johns, Olivera Spasic-Boskovic, Svitlana Korolchuk, Eric Jauniaux, Graham J. Burton, and D. Stephen Charnock-Jones Oxidative Stress, Gene Expression, and Protein Changes Induced in the Human Placenta during Labor Am J Pathol 2007 171: 1168-1179. First published online September 6, 2007; doi:10.2353/ajpath.2007.070528 [Abstract] [Full Text] [PDF] Supplemental Material

Growth Factors, Cytokines, Cell Cycle Molecules: Jonathan D. Schertzer, Stefan M. Gehrig, James G. Ryall, and Gordon S. Lynch Modulation of Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein Interactions Enhances Skeletal Muscle Regeneration and Ameliorates the Dystrophic Pathology in mdx Mice Am J Pathol 2007 171: 1180-1188. First published online September 6, 2007; doi:10.2353/ajpath.2007.070292 [Abstract] [Full Text] [PDF]   Wenhua Li, Chin-Lee Wu, Phillip G. Febbo, and Aria F. Olumi Stromally Expressed c-Jun Regulates Proliferation of Prostate Epithelial Cells Am J Pathol 2007 171: 1189-1198. First published online August 16, 2007; doi:10.2353/ajpath.2007.070285 [Abstract] [Full Text] [PDF] Supplemental Material

Immunopathology and Infectious Disease: Tammy Kielian, Nilufer Esen, Shuliang Liu, Nirmal K. Phulwani, Mohsin M. Syed, Napoleon Phillips, Koren Nishina, Ambrose L. Cheung, Joseph D. Schwartzman, and Jorg J. Ruhe Minocycline Modulates Neuroinflammation Independently of Its Antimicrobial Activity in Staphylococcus aureus-Induced Brain Abscess Am J Pathol 2007 171: 1199-1214. First published online August 23, 2007; doi:10.2353/ajpath.2007.070231 [Abstract] [Full Text] [PDF]   Debby van Riel, Vincent J. Munster, Emmie de Wit, Guus F. Rimmelzwaan, Ron A.M. Fouchier, Albert D.M.E. Osterhaus, and Thijs Kuiken Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals Am J Pathol 2007 171: 1215-1223. First published online August 23, 2007; doi:10.2353/ajpath.2007.070248 [Abstract] [Full Text] [PDF]   Máire E. Doyle, Lori Boggs, Robert Attia, Lauren R. Cooper, Daniel R. Saban, Cuong Q. Nguyen, and Ammon B. Peck Autoimmune Dacryoadenitis of NOD/LtJ Mice and Its Subsequent Effects on Tear Protein Composition Am J Pathol 2007 171: 1224-1236. First published online September 6, 2007; doi:10.2353/ajpath.2007.070388 [Abstract] [Full Text] [PDF] Supplemental Material   Pamela A. Knight, Jeremy K. Brown, Steven H. Wright, Elisabeth M. Thornton, Judith A. Pate, and Hugh R.P. Miller Aberrant Mucosal Mast Cell Protease Expression in the Enteric Epithelium of Nematode-Infected Mice Lacking the Integrin vß6, a Transforming Growth Factor-ß1 Activator Am J Pathol 2007 171: 1237-1248. First published online August 16, 2007; doi:10.2353/ajpath.2007.061245 [Abstract] [Full Text] [PDF]   Kenji Kabashima, Noriko Shiraishi, Kazunari Sugita, Tomoko Mori, Ayako Onoue, Miwa Kobayashi, Jun-ichi Sakabe, Ryutaro Yoshiki, Hirokazu Tamamura, Nobutaka Fujii, Kayo Inaba, and Yoshiki Tokura CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells Am J Pathol 2007 171: 1249-1257. First published online September 6, 2007; doi:10.2353/ajpath.2007.070225 [Abstract] [Full Text] [PDF] Supplemental Material

Neurobiology: Brona Murphy, Mark Dunleavy, Sachiko Shinoda, Clara Schindler, Robert Meller, Carmen Bellver-Estelles, Seiji Hatazaki, Patrick Dicker, Akitaka Yamamoto, Ina Koegel, Xiangping Chu, Weizhen Wang, Zhigang Xiong, Jochen Prehn, Roger Simon, and David Henshall Bcl-w Protects Hippocampus during Experimental Status Epilepticus Am J Pathol 2007 171: 1258-1268. First published online August 16, 2007; doi:10.2353/ajpath.2007.070269 [Abstract] [Full Text] [PDF] Supplemental Material   Jérémie Vitte, Coralie Fassier, Francesco D. Tiziano, Cécile Dalard, Sabrina Soave, Natacha Roblot, Christine Brahe, Pascale Saugier-Veber, Jean Paul Bonnefont, and Judith Melki Refined Characterization of the Expression and Stability of the SMN Gene Products Am J Pathol 2007 171: 1269-1280. First published online August 23, 2007; doi:10.2353/ajpath.2007.070399 [Abstract] [Full Text] [PDF] Supplemental Material   Xiaohui Zhang, Rohini Polavarapu, Hua She, Zixu Mao, and Manuel Yepes Tissue-Type Plasminogen Activator and the Low-Density Lipoprotein Receptor-Related Protein Mediate Cerebral Ischemia-Induced Nuclear Factor-B Pathway Activation Am J Pathol 2007 171: 1281-1290. First published online August 23, 2007; doi:10.2353/ajpath.2007.070472 [Abstract] [Full Text] [PDF]   Yun Ju C. Song, Ditte M.S. Lundvig, Yue Huang, Wei Ping Gai, Peter C. Blumbergs, Peter Højrup, Daniel Otzen, Glenda M. Halliday, and Poul H. Jensen p25 Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy Am J Pathol 2007 171: 1291-1303. First published online September 6, 2007; doi:10.2353/ajpath.2007.070201 [Abstract] [Full Text] [PDF]   Tara L. Spires-Jones, Melanie Meyer-Luehmann, Jennifer D. Osetek, Phillip B. Jones, Edward A. Stern, Brian J. Bacskai, and Bradley T. Hyman Impaired Spine Stability Underlies Plaque-Related Spine Loss in an Alzheimer’s Disease Mouse Model Am J Pathol 2007 171: 1304-1311. First published online August 23, 2007; doi:10.2353/ajpath.2007.070055 [Abstract] [Full Text] [PDF] Supplemental Material   Marta Barrachina, Jesús Moreno, Salvador Juvés, Dolores Moreno, Montse Olivé, and Isidre Ferrer Target Genes of Neuron-Restrictive Silencer Factor Are Abnormally Up-Regulated in Human Myotilinopathy Am J Pathol 2007 171: 1312-1323. First published online September 6, 2007; doi:10.2353/ajpath.2007.070520 [Abstract] [Full Text] [PDF]

Tumorigenesis and Neoplastic Progression: Gerdy B. ten Dam, Els M.A. van de Westerlo, Anurag Purushothaman, Radu V. Stan, Johan Bulten, Fred C.G.J. Sweep, Leon F. Massuger, Kazuyuki Sugahara, and Toin H. van Kuppevelt Antibody GD3G7 Selected against Embryonic Glycosaminoglycans Defines Chondroitin Sulfate-E Domains Highly Up-Regulated in Ovarian Cancer and Involved in Vascular Endothelial Growth Factor Binding Am J Pathol 2007 171: 1324-1333. First published online August 23, 2007; doi:10.2353/ajpath.2007.070111 [Abstract] [Full Text] [PDF]   Neville N.C. Tam, Irwin Leav, and Shuk-Mei Ho Sex Hormones Induce Direct Epithelial and Inflammation-Mediated Oxidative/Nitrosative Stress That Favors Prostatic Carcinogenesis in the Noble Rat Am J Pathol 2007 171: 1334-1341. First published online August 23, 2007; doi:10.2353/ajpath.2007.070199 [Abstract] [Full Text] [PDF]   Halka Klement, Brad St. Croix, Chloe Milsom, Linda May, Qing Guo, Joanne L. Yu, Petr Klement, and Janusz Rak Atherosclerosis and Vascular Aging as Modifiers of Tumor Progression, Angiogenesis, and Responsiveness to Therapy Am J Pathol 2007 171: 1342-1351. First published online September 6, 2007; doi:10.2353/ajpath.2007.070298 [Abstract] [Full Text] [PDF] Supplemental Material   Sudhakar Kalakonda, Shreeram C. Nallar, Ping Gong, Daniel J. Lindner, Simeon E. Goldblum, Sekhar P. Reddy, and Dhananjaya V. Kalvakolanu Tumor Suppressive Protein Gene Associated with Retinoid-Interferon-Induced Mortality (GRIM)-19 Inhibits src-Induced Oncogenic Transformation at Multiple Levels Am J Pathol 2007 171: 1352-1368. First published online September 6, 2007; doi:10.2353/ajpath.2007.070241 [Abstract] [Full Text] [PDF]

Vascular Biology, Atherosclerosis and Endothelium Biology: Maud Jost, Catherine Maillard, Julie Lecomte, Vincent Lambert, Marc Tjwa, Pierre Blaise, Maria-Luz Alvarez Gonzalez, Khalid Bajou, Silvia Blacher, Patrick Motte, Chantal Humblet, Marie Paule Defresne, Marc Thiry, Francis Frankenne, André Gothot, Peter Carmeliet, Jean-Marie Rakic, Jean-Michel Foidart, and Agnès Noël Tumoral and Choroidal Vascularization: Differential Cellular Mechanisms Involving Plasminogen Activator Inhibitor Type I Am J Pathol 2007 171: 1369-1380. First published online August 23, 2007; doi:10.2353/ajpath.2007.070074 [Abstract] [Full Text] [PDF]   Venkatesh Kundumani-Sridharan, Dong Wang, Manjula Karpurapu, Zhimin Liu, Chunxiang Zhang, Nagadhara Dronadula, and Gadiparthi N. Rao Suppression of Activation of Signal Transducer and Activator of Transcription-5B Signaling in the Vessel Wall Reduces Balloon Injury-Induced Neointima Formation Am J Pathol 2007 171: 1381-1394. First published online September 6, 2007; doi:10.2353/ajpath.2007.061258 [Abstract] [Full Text] [PDF]   Shaun W. Jackson, Tomokazu Hoshi, Yan Wu, Xiaofeng Sun, Keiichi Enjyoji, Eva Cszimadia, Christian Sundberg, and Simon C. Robson Disordered Purinergic Signaling Inhibits Pathological Angiogenesis in Cd39/Entpd1-Null Mice Am J Pathol 2007 171: 1395-1404. First published online September 6, 2007; doi:10.2353/ajpath.2007.070190 [Abstract] [Full Text] [PDF]

Correspondence: Jerome Vanderberg, Ann-Kristin Mueller, Kirsten Heiss, Kristin Goetz, Kai Matuschewski, Martina Deckert, and Dirk Schlüter Assessment of Antibody Protection against Malaria Sporozoites Must Be Done by Mosquito Injection of Sporozoites Am J Pathol 2007 171: 1405-1406. First published online September 6, 2007; doi:10.2353/ajpath.2007.070661 [Full Text] [PDF]

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