Biological Perspectives: Alexander Zarbock and Klaus Ley Mechanisms and Consequences of Neutrophil Interaction with the Endothelium Am J Pathol 2008 172: 1-7. First published online December 13, 2007; doi:10.2353/ajpath.2008.070502 [Abstract] [Full Text] [PDF]

Commentaries: Ralf Gold and Fred Lühder Interleukin-17—Extended Features of a Key Player in Multiple Sclerosis Am J Pathol 2008 172: 8-10. First published online December 6, 2007; doi:10.2353/ajpath.2008.070862 [Abstract] [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Daniel Jane-wit, Cengiz Z. Altuntas, Jennifer Monti, Justin M. Johnson, Thomas G. Forsthuber, and Vincent K. Tuohy Sex-Defined T-Cell Responses to Cardiac Self Determine Differential Outcomes of Murine Dilated Cardiomyopathy Am J Pathol 2008 172: 11-21. First published online December 6, 2007; doi:10.2353/ajpath.2008.070324 [Abstract] [Full Text] [PDF]   Dongqi Xing, Fadi G. Hage, Yiu-Fai Chen, Mark A. McCrory, Wenguang Feng, Gregory A. Skibinski, Erum Majid-Hassan, Suzanne Oparil, and Alexander J. Szalai Exaggerated Neointima Formation in Human C-Reactive Protein Transgenic Mice Is IgG Fc Receptor Type I (FcRI)-Dependent Am J Pathol 2008 172: 22-30. First published online December 6, 2007; doi:10.2353/ajpath.2008.070154 [Abstract] [Full Text] [PDF]   Michael E. Lamm, Steven N. Emancipator, Janet K. Robinson, Michifumi Yamashita, Hisashi Fujioka, Jiazhou Qiu, and Andrew G. Plaut Microbial IgA Protease Removes IgA Immune Complexes from Mouse Glomeruli In Vivo: Potential Therapy for IgA Nephropathy Am J Pathol 2008 172: 31-36. First published online December 28, 2007; doi:10.2353/ajpath.2008.070131 [Abstract] [Full Text] [PDF]   Pascale Dufourcq, Lionel Leroux, Jérome Ezan, Betty Descamps, Jean-Marie Daniel Lamazière, Pierre Costet, Caroline Basoni, Catherine Moreau, Urban Deutsch, Thierry Couffinhal, and Cécile Duplàa Regulation of Endothelial Cell Cytoskeletal Reorganization by a Secreted Frizzled-Related Protein-1 and Frizzled 4- and Frizzled 7-Dependent Pathway: Role in Neovessel Formation Am J Pathol 2008 172: 37-49. First published online December 21, 2007; doi:10.2353/ajpath.2008.070130 [Abstract] [Full Text] [PDF] Supplemental Material

Immunopathology and Infectious Disease: Eloisa Amália Vieira Ferro, José Roberto Mineo, Francesca Ietta, Nicoletta Bechi, Roberta Romagnoli, Deise Aparecida Oliveira Silva, Giuseppina Sorda, Estela Bevilacqua, and Luana Ricci Paulesu Macrophage Migration Inhibitory Factor Is Up-Regulated in Human First-Trimester Placenta Stimulated by Soluble Antigen of Toxoplasma gondii, Resulting in Increased Monocyte Adhesion on Villous Explants Am J Pathol 2008 172: 50-58. First published online December 28, 2007; doi:10.2353/ajpath.2008.070432 [Abstract] [Full Text] [PDF]   Magaly Martinez-Ferrer, Juan M. Iturregui, Consolate Uwamariya, Jonathan Starkman, Ali-Reza Sharif-Afshar, Kichiya Suzuki, Wit Visedsindh, Robert J. Matusik, Roger R. Dmochowski, and Neil A. Bhowmick Role of Nicotinic and Estrogen Signaling during Experimental Acute and Chronic Bladder Inflammation Am J Pathol 2008 172: 59-67. First published online December 13, 2007; doi:10.2353/ajpath.2008.070529 [Abstract] [Full Text] [PDF]   Vladislav Dolgachev, Aaron A. Berlin, and Nicholas W. Lukacs Eosinophil Activation of Fibroblasts from Chronic Allergen-Induced Disease Utilizes Stem Cell Factor for Phenotypic Changes Am J Pathol 2008 172: 68-76. First published online December 21, 2007; doi:10.2353/ajpath.2008.070082 [Abstract] [Full Text] [PDF]

Metabolic, Endocrine and Genitourinary Pathobiology: Yoav Yinon, Ori Nevo, Jing Xu, Ariel Many, Alessandro Rolfo, Tullia Todros, Martin Post, and Isabella Caniggia Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor-β3 Am J Pathol 2008 172: 77-85. First published online December 21, 2007; doi:10.2353/ajpath.2008.070640 [Abstract] [Full Text] [PDF]   Marianne Demerjian, Jean-Pierre Hachem, Erwin Tschachler, Geertrui Denecker, Wim Declercq, Peter Vandenabeele, Theodora Mauro, Melanie Hupe, Debra Crumrine, Truus Roelandt, Evi Houben, Peter M. Elias, and Kenneth R. Feingold Acute Modulations in Permeability Barrier Function Regulate Epidermal Cornification: Role of Caspase-14 and the Protease-Activated Receptor Type 2 Am J Pathol 2008 172: 86-97. First published online December 21, 2007; doi:10.2353/ajpath.2008.070161 [Abstract] [Full Text] [PDF] Supplemental Material

Molecular Pathogenesis of Genetic and Inherited Diseases: Juan T. Borda, Xavier Alvarez, Mahesh Mohan, Marion S. Ratterree, Kathrine Phillippi-Falkenstein, Andrew A. Lackner, and Bruce A. Bunnell Clinical and Immunopathologic Alterations in Rhesus Macaques Affected with Globoid Cell Leukodystrophy Am J Pathol 2008 172: 98-111. First published online December 28, 2007; doi:10.2353/ajpath.2008.070404 [Abstract] [Full Text] [PDF]   Calogera M. Simonaro, Marina D’Angelo, Xingxuan He, Efrat Eliyahu, Nataly Shtraizent, Mark E. Haskins, and Edward H. Schuchman Mechanism of Glycosaminoglycan-Mediated Bone and Joint Disease: Implications for the Mucopolysaccharidoses and Other Connective Tissue Diseases Am J Pathol 2008 172: 112-122. First published online December 13, 2007; doi:10.2353/ajpath.2008.070564 [Abstract] [Full Text] [PDF]   Patrice Delobel, Isabelle Lavenir, Graham Fraser, Esther Ingram, Max Holzer, Bernardino Ghetti, Maria Grazia Spillantini, R. Anthony Crowther, and Michel Goedert Analysis of Tau Phosphorylation and Truncation in a Mouse Model of Human Tauopathy Am J Pathol 2008 172: 123-131. First published online December 13, 2007; doi:10.2353/ajpath.2008.070627 [Abstract] [Full Text] [PDF]

Neurobiology: Werner Stenzel, Sabine Soltek, Monica Sanchez-Ruiz, Shizuo Akira, Hrvoje Miletic, Dirk Schlüter, and Martina Deckert Both TLR2 and TLR4 Are Required for the Effective Immune Response in Staphylococcus aureus-Induced Experimental Murine Brain Abscess Am J Pathol 2008 172: 132-145. First published online December 28, 2007; doi:10.2353/ajpath.2008.070567 [Abstract] [Full Text] [PDF]   John S. Tzartos, Manuel A. Friese, Matthew J. Craner, Jackie Palace, Jia Newcombe, Margaret M. Esiri, and Lars Fugger Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis Am J Pathol 2008 172: 146-155. First published online December 21, 2007; doi:10.2353/ajpath.2008.070690 [Abstract] [Full Text] [PDF] Supplemental Material

Tumorigenesis and Neoplastic Progression: Carolina Espina, María Virtudes Céspedes, Miguel Angel García-Cabezas, María Teresa Gómez del Pulgar, Alicia Boluda, Lourdes García Oroz, Paloma Cejas, Manuel Nistal, Ramón Mangues, and Juan Carlos Lacal A Critical Role for Rac1 in Tumor Progression of Human Colorectal Adenocarcinoma Cells Am J Pathol 2008 172: 156-166. First published online December 28, 2007; doi:10.2353/ajpath.2008.070561 [Abstract] [Full Text] [PDF]   Marie-Astrid Hervé, Hélène Buteau-Lozano, Roger Vassy, Ivan Bieche, Guillaume Velasco, Marika Pla, Gérard Perret, Samia Mourah, and Martine Perrot-Applanat Overexpression of Vascular Endothelial Growth Factor 189 in Breast Cancer Cells Leads to Delayed Tumor Uptake with Dilated Intratumoral Vessels Am J Pathol 2008 172: 167-178. First published online December 13, 2007; doi:10.2353/ajpath.2008.070181 [Abstract] [Full Text] [PDF]   Hiroshi Koyama, Nobutaka Kobayashi, Michihiko Harada, Michiko Takeoka, Yoshiko Kawai, Kenji Sano, Minoru Fujimori, Jun Amano, Toshio Ohhashi, Reiji Kannagi, Koji Kimata, Shun’ichiro Taniguchi, and Naoki Itano Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis: Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment Am J Pathol 2008 172: 179-193. First published online December 13, 2007; doi:10.2353/ajpath.2008.070360 [Abstract] [Full Text] [PDF]   Lisa M. Arendt and Linda A. Schuler Prolactin Drives Estrogen Receptor--Dependent Ductal Expansion and Synergizes with Transforming Growth Factor- to Induce Mammary Tumors in Males Am J Pathol 2008 172: 194-202. First published online December 21, 2007; doi:10.2353/ajpath.2008.070597 [Abstract] [Full Text] [PDF]   Cornelia Stock, Eva Bozsaky, Franz Watzinger, Ulrike Poetschger, Lukas Orel, Thomas Lion, Agata Kowalska, and Peter F. Ambros Genes Proximal and Distal to MYCN Are Highly Expressed in Human Neuroblastoma as Visualized by Comparative Expressed Sequence Hybridization Am J Pathol 2008 172: 203-214. First published online December 28, 2007; doi:10.2353/ajpath.2008.061263 [Abstract] [Full Text] [PDF]   Askar Akimzhanov, Laszlo Krenacs, Timm Schlegel, Stefan Klein-Hessling, Enikö Bagdi, Eva Stelkovics, Eisaku Kondo, Sergei Chuvpilo, Philipp Wilke, Andris Avots, Stefan Gattenlöhner, Hans-Konrad Müller-Hermelink, Alois Palmetshofer, and Edgar Serfling Epigenetic Changes and Suppression of the Nuclear Factor of Activated T Cell 1 (NFATC1) Promoter in Human Lymphomas with Defects in Immunoreceptor Signaling Am J Pathol 2008 172: 215-224. First published online December 21, 2007; doi:10.2353/ajpath.2008.070294 [Abstract] [Full Text] [PDF] Supplemental Material   Yi Peng, Caihong X. Li, Fei Chen, Zhengxin Wang, Martin Ligr, Jonathan Melamed, Jianjun Wei, William Gerald, Michele Pagano, Michael J. Garabedian, and Peng Lee Stimulation of Prostate Cancer Cellular Proliferation and Invasion by the Androgen Receptor Co-Activator ARA70β Am J Pathol 2008 172: 225-235. First published online December 21, 2007; doi:10.2353/ajpath.2008.070065 [Abstract] [Full Text] [PDF]   Teresa Chiaverotti, Suzana S. Couto, Annemarie Donjacour, Jian-Hua Mao, Hiroki Nagase, Robert D. Cardiff, Gerald R. Cunha, and Allan Balmain Dissociation of Epithelial and Neuroendocrine Carcinoma Lineages in the Transgenic Adenocarcinoma of Mouse Prostate Model of Prostate Cancer Am J Pathol 2008 172: 236-246. First published online December 21, 2007; doi:10.2353/ajpath.2008.070602 [Abstract] [Full Text] [PDF] Supplemental Material

Vascular Biology, Atherosclerosis and Endothelium Biology: Maurice Nachtigal, Abdul Ghaffar, and Eugene P. Mayer Galectin-3 Gene Inactivation Reduces Atherosclerotic Lesions and Adventitial Inflammation in ApoE-Deficient Mice Am J Pathol 2008 172: 247-255. First published online December 21, 2007; doi:10.2353/ajpath.2008.070348 [Abstract] [Full Text] [PDF]   Allan Lawrie, Elizabeth Waterman, Mark Southwood, David Evans, Jay Suntharalingam, Sheila Francis, David Crossman, Peter Croucher, Nicholas Morrell, and Christopher Newman Evidence of a Role for Osteoprotegerin in the Pathogenesis of Pulmonary Arterial Hypertension Am J Pathol 2008 172: 256-264. First published online December 21, 2007; doi:10.2353/ajpath.2008.070395 [Abstract] [Full Text] [PDF]   Sarah Nolan, Rachel Dixon, Keith Norman, Paul Hellewell, and Victoria Ridger Nitric Oxide Regulates Neutrophil Migration through Microparticle Formation Am J Pathol 2008 172: 265-273. First published online December 13, 2007; doi:10.2353/ajpath.2008.070069 [Abstract] [Full Text] [PDF] Supplemental Material

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