Biological Perspectives: Gabor G. Kovacs and Herbert Budka Prion Diseases: From Protein to Cell Pathology Am J Pathol 2008 172: 555-565. First published online February 2, 2008; doi:10.2353/ajpath.2008.070442 [Abstract] [Full Text] [PDF]

Commentaries: Heleen Rienstra, Clark J. Zeebregts, and Jan-Luuk Hillebrands The Source of Neointimal Cells in Vein Grafts: Does the Origin Matter? Am J Pathol 2008 172: 566-570. First published online February 14, 2008; doi:10.2353/ajpath.2008.071219 [Abstract] [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Jianping Sun, Hui Chen, Cheng Chen, Jeffrey A. Whitsett, Yuji Mishina, Pablo Bringas, Jr., Jeffrey C. Ma, David Warburton, and Wei Shi Prenatal Lung Epithelial Cell-Specific Abrogation of Alk3-Bone Morphogenetic Protein Signaling Causes Neonatal Respiratory Distress by Disrupting Distal Airway Formation Am J Pathol 2008 172: 571-582. First published online February 7, 2008; doi:10.2353/ajpath.2008.070286 [Abstract] [Full Text] [PDF]   Judson M. Englert, Lana E. Hanford, Naftali Kaminski, Jacob M. Tobolewski, Roderick J. Tan, Cheryl L. Fattman, Lasse Ramsgaard, Thomas J. Richards, Inna Loutaev, Peter P. Nawroth, Michael Kasper, Angelika Bierhaus, and Tim D. Oury A Role for the Receptor for Advanced Glycation End Products in Idiopathic Pulmonary Fibrosis Am J Pathol 2008 172: 583-591. First published online February 2, 2008; doi:10.2353/ajpath.2008.070569 [Abstract] [Full Text] [PDF]   Wei Jiang, Sean R. Hall, Michael P.W. Moos, Richard Yang Cao, Satoshi Ishii, Kofo O. Ogunyankin, Luis G. Melo, and Colin D. Funk Endothelial Cysteinyl Leukotriene 2 Receptor Expression Mediates Myocardial Ischemia-Reperfusion Injury Am J Pathol 2008 172: 592-602. First published online February 14, 2008; doi:10.2353/ajpath.2008.070834 [Abstract] [Full Text] [PDF]   Teruo Hidaka, Yusuke Suzuki, Michifumi Yamashita, Terumi Shibata, Yuichi Tanaka, Satoshi Horikoshi, and Yasuhiko Tomino Amelioration of Crescentic Glomerulonephritis by RhoA Kinase Inhibitor, Fasudil, through Podocyte Protection and Prevention of Leukocyte Migration Am J Pathol 2008 172: 603-614. First published online February 2, 2008; doi:10.2353/ajpath.2008.070196 [Abstract] [Full Text] [PDF]   Kewal Asosingh, Micheala A. Aldred, Amit Vasanji, Judith Drazba, Jacqueline Sharp, Carol Farver, Suzy A.A. Comhair, Weiling Xu, Lauren Licina, Lan Huang, Bela Anand-Apte, Mervin C. Yoder, Rubin M. Tuder, and Serpil C. Erzurum Circulating Angiogenic Precursors in Idiopathic Pulmonary Arterial Hypertension Am J Pathol 2008 172: 615-627. First published online February 7, 2008; doi:10.2353/ajpath.2008.070705 [Abstract] [Full Text] [PDF]   Volha Ninichuk, Sebastian Clauss, Onkar Kulkarni, Holger Schmid, Stephan Segerer, Ewa Radomska, Dirk Eulberg, Klaus Buchner, Norma Selve, Sven Klussmann, and Hans-Joachim Anders Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3'PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice Am J Pathol 2008 172: 628-637. First published online February 7, 2008; doi:10.2353/ajpath.2008.070601 [Abstract] [Full Text] [PDF]

Epithelial and Mesenchymal Cell Biology: Taiichiro Chikama, Chia-Yang Liu, Johanna T.A. Meij, Yasuhito Hayashi, I-Jong Wang, Liu Yang, Teruo Nishida, and Winston W.Y. Kao Excess FGF-7 in Corneal Epithelium Causes Corneal Intraepithelial Neoplasia in Young Mice and Epithelium Hyperplasia in Adult Mice Am J Pathol 2008 172: 638-649. First published online February 14, 2008; doi:10.2353/ajpath.2008.070897 [Abstract] [Full Text] [PDF] Supplemental Material   Motonobu Nakamura, Jun-ichiro Jo, Yasuhiko Tabata, and Osamu Ishikawa Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model Am J Pathol 2008 172: 650-658. First published online February 2, 2008; doi:10.2353/ajpath.2008.061249 [Abstract] [Full Text] [PDF]   Karol Dokladny, Dongmei Ye, John C. Kennedy, Pope L. Moseley, and Thomas Y. Ma Cellular and Molecular Mechanisms of Heat Stress-Induced Up-Regulation of Occludin Protein Expression: Regulatory Role of Heat Shock Factor-1 Am J Pathol 2008 172: 659-670. First published online February 14, 2008; doi:10.2353/ajpath.2008.070522 [Abstract] [Full Text] [PDF]

Gastrointestinal, Hepatobiliary and Pancreatic Pathology: Sabine Westphal, Andreas Lügering, Julia von Wedel, Christof von Eiff, Christian Maaser, Thomas Spahn, Gerhard Heusipp, M. Alexander Schmidt, Hermann Herbst, Ifor R. Williams, Wolfram Domschke, and Torsten Kucharzik Resistance of Chemokine Receptor 6-Deficient Mice to Yersinia Enterocolitica Infection: Evidence of Defective M-Cell Formation in Vivo Am J Pathol 2008 172: 671-680. First published online February 7, 2008; doi:10.2353/ajpath.2008.070393 [Abstract] [Full Text] [PDF]   Bernhard Setzer, Dirk Lebrecht, and Ulrich A. Walker Pyrimidine Nucleoside Depletion Sensitizes to the Mitochondrial Hepatotoxicity of the Reverse Transcriptase Inhibitor Stavudine Am J Pathol 2008 172: 681-690. First published online February 14, 2008; doi:10.2353/ajpath.2008.070613 [Abstract] [Full Text] [PDF]   Fabien Milliat, Jean-Christophe Sabourin, Georges Tarlet, Valerie Holler, Eric Deutsch, Valérie Buard, Radia Tamarat, Azeddine Atfi, Marc Benderitter, and Agnès François Essential Role of Plasminogen Activator Inhibitor Type-1 in Radiation Enteropathy Am J Pathol 2008 172: 691-701. First published online February 14, 2008; doi:10.2353/ajpath.2008.070930 [Abstract] [Full Text] [PDF]   David Elphick, Susan Liddell, and Yashwant R. Mahida Impaired Luminal Processing of Human Defensin-5 in Crohn’s Disease: Persistence in a Complex with Chymotrypsinogen and Trypsin Am J Pathol 2008 172: 702-713. First published online February 7, 2008; doi:10.2353/ajpath.2008.070755 [Abstract] [Full Text] [PDF]

Immunopathology and Infectious Disease: Carol A. Wu, John J. Peluso, John D. Shanley, Lynn Puddington, and Roger S. Thrall Murine Cytomegalovirus Influences Foxj1 Expression, Ciliogenesis, and Mucus Plugging in Mice with Allergic Airway Disease Am J Pathol 2008 172: 714-724. First published online February 7, 2008; doi:10.2353/ajpath.2008.070462 [Abstract] [Full Text] [PDF]   Juan T. Borda, Xavier Alvarez, Mahesh Mohan, Atsuhiko Hasegawa, Andrea Bernardino, Sherrie Jean, Pyone Aye, and Andrew A. Lackner CD163, a Marker of Perivascular Macrophages, Is Up-Regulated by Microglia in Simian Immunodeficiency Virus Encephalitis after Haptoglobin-Hemoglobin Complex Stimulation and Is Suggestive of Breakdown of the Blood-Brain Barrier Am J Pathol 2008 172: 725-737. First published online February 14, 2008; doi:10.2353/ajpath.2008.070848 [Abstract] [Full Text] [PDF] Supplemental Material

Metabolic, Endocrine and Genitourinary Pathobiology: Paola Dongiovanni, Luca Valenti, Anna Ludovica Fracanzani, Stefano Gatti, Gaetano Cairo, and Silvia Fargion Iron Depletion by Deferoxamine Up-Regulates Glucose Uptake and Insulin Signaling in Hepatoma Cells and in Rat Liver Am J Pathol 2008 172: 738-747. First published online February 2, 2008; doi:10.2353/ajpath.2008.070097 [Abstract] [Full Text] [PDF]   Anne-Catherine Gérard, Sylvie Poncin, Bertrand Caetano, Pierre Sonveaux, Jean-Nicolas Audinot, Olivier Feron, Ides M. Colin, and Fabrice Soncin Iodine Deficiency Induces a Thyroid Stimulating Hormone-Independent Early Phase of Microvascular Reshaping in the Thyroid Am J Pathol 2008 172: 748-760. First published online February 14, 2008; doi:10.2353/ajpath.2008.070841 [Abstract] [Full Text] [PDF] Supplemental Material

Molecular Pathogenesis of Genetic and Inherited Diseases: Dominic Cosgrove, Daniel T. Meehan, Duane Delimont, Ambra Pozzi, Xiwu Chen, Kathyrn D. Rodgers, Richard M. Tempero, Marisa Zallocchi, and Velidi H. Rao Integrin 1β1 Regulates Matrix Metalloproteinases via P38 Mitogen-Activated Protein Kinase in Mesangial Cells: Implications for Alport Syndrome Am J Pathol 2008 172: 761-773. First published online February 7, 2008; doi:10.2353/ajpath.2008.070473 [Abstract] [Full Text] [PDF]   Kanneboyina Nagaraju, Rashmi Rawat, Edina Veszelovszky, Rachana Thapliyal, Akanchha Kesari, Susan Sparks, Nina Raben, Paul Plotz, and Eric P. Hoffman Dysferlin Deficiency Enhances Monocyte Phagocytosis: A Model for the Inflammatory Onset of Limb-Girdle Muscular Dystrophy 2B Am J Pathol 2008 172: 774-785. First published online February 14, 2008; doi:10.2353/ajpath.2008.070327 [Abstract] [Full Text] [PDF]

Neurobiology: Dick Terwel, David Muyllaert, Ilse Dewachter, Peter Borghgraef, Sophie Croes, Herman Devijver, and Fred Van Leuven Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice Am J Pathol 2008 172: 786-798. First published online February 7, 2008; doi:10.2353/ajpath.2008.070904 [Abstract] [Full Text] [PDF] Supplemental Material   Erin E. McCandless, Laura Piccio, B. Mark Woerner, Robert E. Schmidt, Joshua B. Rubin, Anne H. Cross, and Robyn S. Klein Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis Am J Pathol 2008 172: 799-808. First published online February 14, 2008; doi:10.2353/ajpath.2008.070918 [Abstract] [Full Text] [PDF]

Tumorigenesis and Neoplastic Progression: Pushkar A. Phadke, Kedar S. Vaidya, Kevin T. Nash, Douglas R. Hurst, and Danny R. Welch BRMS1 Suppresses Breast Cancer Experimental Metastasis to Multiple Organs by Inhibiting Several Steps of the Metastatic Process Am J Pathol 2008 172: 809-817. First published online February 14, 2008; doi:10.2353/ajpath.2008.070772 [Abstract] [Full Text] [PDF] Supplemental Material

Vascular Biology, Atherosclerosis and Endothelium Biology: Yoichi Takami, Hironori Nakagami, Ryuichi Morishita, Tomohiro Katsuya, Hiroki Hayashi, Masaki Mori, Hiroshi Koriyama, Yoshichika Baba, Osamu Yasuda, Hiromi Rakugi, Toshio Ogihara, and Yasufumi Kaneda Potential Role of CYLD (Cylindromatosis) as a Deubiquitinating Enzyme in Vascular Cells Am J Pathol 2008 172: 818-829. First published online February 2, 2008; doi:10.2353/ajpath.2008.070312 [Abstract] [Full Text] [PDF]   Audrey Billon, Stéphanie Lehoux, Laetitia Lam Shang Leen, Henrik Laurell, Cédric Filipe, Vincent Benouaich, Laurent Brouchet, Chantal Dessy, Pierre Gourdy, Alain-Pierre Gadeau, Alain Tedgui, Jean-Luc Balligand, and Jean-François Arnal The Estrogen Effects on Endothelial Repair and Mitogen-Activated Protein Kinase Activation Are Abolished in Endothelial Nitric-Oxide (NO) Synthase Knockout Mice, but Not by NO Synthase Inhibition by N-Nitro-L-arginine Methyl Ester Am J Pathol 2008 172: 830-838. First published online February 14, 2008; doi:10.2353/ajpath.2008.070439 [Abstract] [Full Text] [PDF] Supplemental Material   Yanpeng Diao, Steve Guthrie, Shen-Ling Xia, Xiaosen Ouyang, Li Zhang, Jing Xue, Pui Lee, Maria Grant, Edward Scott, and Mark S. Segal Long-Term Engraftment of Bone Marrow-Derived Cells in the Intimal Hyperplasia Lesion of Autologous Vein Grafts Am J Pathol 2008 172: 839-848. First published online February 14, 2008; doi:10.2353/ajpath.2008.070840 [Abstract] [Full Text] [PDF] Supplemental Material

Reviewer Acknowledgment: Reviewer Acknowledgment Am J Pathol 2008 172: 849-854. First published online February 14, 2008; doi:10.2353/ajpath.2008.071173 [Full Text] [PDF]

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