Editorials: Michael P. Lisanti What’s Next at AJP? Am J Pathol 2008 173: 1. ; doi: 10.2353/ajpath.2008.080390 [Full Text] [PDF]

Biological Perspectives: Pal Pacher and Csaba Szabo Role of the Peroxynitrite-Poly(ADP-Ribose) Polymerase Pathway in Human Disease Am J Pathol 2008 173: 2-13. First published online June 5, 2008; doi:10.2353/ajpath.2008.080019 [Abstract] [Full Text] [PDF]

Reviews: Marlon R. Schneider, Sabine Werner, Ralf Paus, and Eckhard Wolf Beyond Wavy Hairs: The Epidermal Growth Factor Receptor and Its Ligands in Skin Biology and Pathology Am J Pathol 2008 173: 14-24. First published online June 13, 2008; doi:10.2353/ajpath.2008.070942 [Abstract] [Full Text] [PDF]

Commentaries: Dennis L. Kolson YKL-40: A Candidate Biomarker for Simian Immunodeficiency Virus and Human Immunodeficiency Virus Encephalitis? Am J Pathol 2008 173: 25-29. ; doi: 10.2353/ajpath.2008.080389 [Abstract] [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Myrto Giannopoulou, Chunsun Dai, Xiaoyue Tan, Xiaoyan Wen, George K. Michalopoulos, and Youhua Liu Hepatocyte Growth Factor Exerts Its Anti-Inflammatory Action by Disrupting Nuclear Factor-B Signaling Am J Pathol 2008 173: 30-41. First published online May 23, 2008; doi:10.2353/ajpath.2008.070583 [Abstract] [Full Text] [PDF]   Monique E. De Paepe, Sravanthi Gundavarapu, Umadevi Tantravahi, John R. Pepperell, Sheila A. Haley, Francois I. Luks, and Quanfu Mao Fas-Ligand-Induced Apoptosis of Respiratory Epithelial Cells Causes Disruption of Postcanalicular Alveolar Development Am J Pathol 2008 173: 42-56. First published online June 5, 2008; doi:10.2353/ajpath.2008.071123 [Abstract] [Full Text] [PDF]   Marcin Bujak, Marcin Dobaczewski, Khaled Chatila, Leonardo H. Mendoza, Na Li, Anilkumar Reddy, and Nikolaos G. Frangogiannis Interleukin-1 Receptor Type I Signaling Critically Regulates Infarct Healing and Cardiac Remodeling Am J Pathol 2008 173: 57-67. First published online June 5, 2008; doi:10.2353/ajpath.2008.070974 [Abstract] [Full Text] [PDF]

Cell Injury, Repair, Aging and Apoptosis: Kathleen C. Flanders, Benjamin M. Ho, Praveen R. Arany, Christina Stuelten, Mizuko Mamura, Miya Okada Paterniti, Anastasia Sowers, James B. Mitchell, and Anita B. Roberts Absence of Smad3 Induces Neutrophil Migration after Cutaneous Irradiation: Possible Contribution to Subsequent Radioprotection Am J Pathol 2008 173: 68-76. First published online May 23, 2008; doi:10.2353/ajpath.2008.070937 [Abstract] [Full Text] [PDF]   Heike Beck, Matthias Semisch, Carsten Culmsee, Nikolaus Plesnila, and Antonis K. Hatzopoulos Egr-1 Regulates Expression of the Glial Scar Component Phosphacan in Astrocytes after Experimental Stroke Am J Pathol 2008 173: 77-92. First published online June 13, 2008; doi:10.2353/ajpath.2008.070648 [Abstract] [Full Text] [PDF] Supplemental Material

Immunopathology and Infectious Disease: Anna Brunn, Olaf Utermöhlen, Mariana Carstov, Monica Sánchez Ruiz, Hrvoje Miletic, Dirk Schlüter, and Martina Deckert CD4 T Cells Mediate Axonal Damage and Spinal Cord Motor Neuron Apoptosis in Murine P0106–125-Induced Experimental Autoimmune Neuritis Am J Pathol 2008 173: 93-105. First published online June 5, 2008; doi:10.2353/ajpath.2008.071101 [Abstract] [Full Text] [PDF]   Mahesh Mohan, Pyone P. Aye, Juan T. Borda, Xavier Alvarez, and Andrew A. Lackner CCAAT/Enhancer Binding Protein β Is a Major Mediator of Inflammation and Viral Replication in the Gastrointestinal Tract of Simian Immunodeficiency Virus-Infected Rhesus Macaques Am J Pathol 2008 173: 106-118. First published online June 5, 2008; doi:10.2353/ajpath.2008.080108 [Abstract] [Full Text] [PDF] Supplemental Material   Stefanie Gaupp, Barbara Cannella, and Cedric S. Raine Amelioration of Experimental Autoimmune Encephalomyelitis in IL-4R–/– Mice Implicates Compensatory Up-Regulation of Th2-Type Cytokines Am J Pathol 2008 173: 119-129. First published online June 5, 2008; doi:10.2353/ajpath.2008.071156 [Abstract] [Full Text] [PDF]   Dafna Bonneh-Barkay, Stephanie J. Bissel, Gouji Wang, Kenneth N. Fish, Georgina C.B. Nicholl, Samuel W. Darko, Rafael Medina-Flores, Michael Murphey-Corb, Premeela A. Rajakumar, Julia Nyaundi, John W. Mellors, Robert Bowser, and Clayton A. Wiley YKL-40, a Marker of Simian Immunodeficiency Virus Encephalitis, Modulates the Biological Activity of Basic Fibroblast Growth Factor Am J Pathol 2008 173: 130-143. First published online June 13, 2008; doi:10.2353/ajpath.2008.080045 [Abstract] [Full Text] [PDF] Supplemental Material   Michelle Lin, Patricia Jackson, Angus M. Tester, Eugenia Diaconu, Christopher M. Overall, J. Edwin Blalock, and Eric Pearlman Matrix Metalloproteinase-8 Facilitates Neutrophil Migration through the Corneal Stromal Matrix by Collagen Degradation and Production of the Chemotactic Peptide Pro-Gly-Pro Am J Pathol 2008 173: 144-153. First published online June 13, 2008; doi:10.2353/ajpath.2008.080081 [Abstract] [Full Text] [PDF]   James F. George, Andrea Braun, Todd M. Brusko, Reny Joseph, Subhashini Bolisetty, Clive H. Wasserfall, Mark A. Atkinson, Anupam Agarwal, and Matthias H. Kapturczak Suppression by CD4+CD25+ Regulatory T Cells Is Dependent on Expression of Heme Oxygenase-1 in Antigen-Presenting Cells Am J Pathol 2008 173: 154-160. First published online May 29, 2008; doi:10.2353/ajpath.2008.070963 [Abstract] [Full Text] [PDF]

Musculoskeletal Pathology: Valeria M. Dejica, John S. Mort, Sheila Laverty, M. David Percival, John Antoniou, David J. Zukor, and A. Robin Poole Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage Am J Pathol 2008 173: 161-169. First published online May 29, 2008; doi:10.2353/ajpath.2008.070494 [Abstract] [Full Text] [PDF]   Stefano Gastaldello, Simona D'Angelo, Susanna Franzoso, Marina Fanin, Corrado Angelini, Romeo Betto, and Dorianna Sandonà Inhibition of Proteasome Activity Promotes the Correct Localization of Disease-Causing -Sarcoglycan Mutants in HEK-293 Cells Constitutively Expressing β-, -, and -Sarcoglycan Am J Pathol 2008 173: 170-181. First published online June 5, 2008; doi:10.2353/ajpath.2008.071146 [Abstract] [Full Text] [PDF] Supplemental Material

Neurobiology: Lionel M. Igaz, Linda K. Kwong, Yan Xu, Adam C. Truax, Kunihiro Uryu, Manuela Neumann, Christopher M. Clark, Lauren B. Elman, Bruce L. Miller, Murray Grossman, Leo F. McCluskey, John Q. Trojanowski, and Virginia M.-Y. Lee Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Am J Pathol 2008 173: 182-194. First published online June 5, 2008; doi:10.2353/ajpath.2008.080003 [Abstract] [Full Text] [PDF] Supplemental Material

Tumorigenesis and Neoplastic Progression: Karl R.N. Baumforth, Anna Birgersdotter, Gary M. Reynolds, Wenbin Wei, Georgia Kapatai, Joanne R. Flavell, Emma Kalk, Karen Piper, Steve Lee, Lee Machado, Kerry Hadley, Anne Sundblad, Jan Sjoberg, Magnus Bjorkholm, Anna A. Porwit, Lee-Fah Yap, Soohwang Teo, Richard G. Grundy, Lawrence S. Young, Ingemar Ernberg, Ciaran B.J. Woodman, and Paul G. Murray Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin’s Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells Am J Pathol 2008 173: 195-204. First published online May 23, 2008; doi:10.2353/ajpath.2008.070845 [Abstract] [Full Text] [PDF] Supplemental Material   Takamitsu Sasaki, Toru Nakamura, Robert B. Rebhun, Hua Cheng, Katherine Stemke Hale, Rachel Z. Tsan, Isaiah J. Fidler, and Robert R. Langley Modification of the Primary Tumor Microenvironment by Transforming Growth Factor -Epidermal Growth Factor Receptor Signaling Promotes Metastasis in an Orthotopic Colon Cancer Model Am J Pathol 2008 173: 205-216. ; doi: 10.2353/ajpath.2008.071147 [Abstract] [Full Text] [PDF]   Takeo Fujita, Weijun Liu, Hiroyoshi Doihara, and Yong Wan Regulation of Skp2-p27 Axis by the Cdh1/Anaphase-Promoting Complex Pathway in Colorectal Tumorigenesis Am J Pathol 2008 173: 217-228. First published online June 5, 2008; doi:10.2353/ajpath.2008.070957 [Abstract] [Full Text] [PDF] Supplemental Material   Michael F. McEntee, Carol Ziegler, Danielle Reel, Kenneth Tomer, Ahmed Shoieb, Mark Ray, Xiaoou Li, Nancy Neilsen, Fred B. Lih, Dorcas O'Rourke, and Jay Whelan Dietary n-3 Polyunsaturated Fatty Acids Enhance Hormone Ablation Therapy in Androgen-Dependent Prostate Cancer Am J Pathol 2008 173: 229-241. First published online June 13, 2008; doi:10.2353/ajpath.2008.070989 [Abstract] [Full Text] [PDF]   Kui Nie, Mario Gomez, Pablo Landgraf, Jose-Francisco Garcia, Yifang Liu, Leonard H.C. Tan, Amy Chadburn, Thomas Tuschl, Daniel M. Knowles, and Wayne Tam MicroRNA-Mediated Down-Regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg Cells: A Potential Pathogenetic Lesion in Hodgkin Lymphomas Am J Pathol 2008 173: 242-252. ; doi: 10.2353/ajpath.2008.080009 [Abstract] [Full Text] [PDF]   Hendrik W. van Deventer, Qing Ping Wu, Daniel T. Bergstralh, Beckley K. Davis, Brian P. O'Connor, Jenny P.-Y. Ting, and Jonathan S. Serody C-C Chemokine Receptor 5 on Pulmonary Fibrocytes Facilitates Migration and Promotes Metastasis via Matrix Metalloproteinase 9 Am J Pathol 2008 173: 253-264. First published online June 5, 2008; doi:10.2353/ajpath.2008.070732 [Abstract] [Full Text] [PDF]

Vascular Biology, Atherosclerosis and Endothelium Biology: Cornelia Halin, Hermann Fahrngruber, Josef G. Meingassner, Guido Bold, Amanda Littlewood-Evans, Anton Stuetz, and Michael Detmar Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor Am J Pathol 2008 173: 265-277. First published online June 5, 2008; doi:10.2353/ajpath.2008.071074 [Abstract] [Full Text] [PDF]   Bernard Ho, Guangpei Hou, J. Geoffrey Pickering, Gregory Hannigan, B. Lowell Langille, and Michelle P. Bendeck Integrin-Linked Kinase in the Vascular Smooth Muscle Cell Response to Injury Am J Pathol 2008 173: 278-288. First published online June 5, 2008; doi:10.2353/ajpath.2008.071046 [Abstract] [Full Text] [PDF]   Francesca Vinchi, Stefania Gastaldi, Lorenzo Silengo, Fiorella Altruda, and Emanuela Tolosano Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload Am J Pathol 2008 173: 289-299. First published online June 13, 2008; doi:10.2353/ajpath.2008.071130 [Abstract] [Full Text] [PDF]

Corrections: Corrections Am J Pathol 2008 173: 300. ; doi: 10.2353/ajpath.2008.080387 [Full Text] [PDF]

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