Guest Editorials: Linda M. McManus Mission, Leadership, and Scientific Discovery: Looking to the Future Am J Pathol 2008 173: 599. First published online August 7, 2008; doi:10.2353/ajpath.2008.080435 [Full Text] [PDF]

Reviews: DeLisa Fairweather, Sylvia Frisancho-Kiss, and Noel R. Rose Sex Differences in Autoimmune Disease from a Pathological Perspective Am J Pathol 2008 173: 600-609. First published online August 7, 2008; doi:10.2353/ajpath.2008.071008 [Abstract] [Full Text] [PDF]

Regular Articles:

Cell Injury, Repair, Aging and Apoptosis: Lillian B. Nanney, Christopher D. Woodrell, Mathew R. Greives, Nancy L. Cardwell, Alonda C. Pollins, Tara A. Bancroft, Adrianne Chesser, Marek Michalak, Mohammad Rahman, John W. Siebert, and Leslie I. Gold Calreticulin Enhances Porcine Wound Repair by Diverse Biological Effects Am J Pathol 2008 173: 610-630. First published online September 1, 2008; doi:10.2353/ajpath.2008.071027 [Abstract] [Full Text] [PDF]   Nasim Shweke, Nada Boulos, Chantal Jouanneau, Sophie Vandermeersch, Gerry Melino, Jean-Claude Dussaule, Christos Chatziantoniou, Pierre Ronco, and Jean-Jacques Boffa Tissue Transglutaminase Contributes to Interstitial Renal Fibrosis by Favoring Accumulation of Fibrillar Collagen through TGF-β Activation and Cell Infiltration Am J Pathol 2008 173: 631-642. First published online August 7, 2008; doi:10.2353/ajpath.2008.080025 [Abstract] [Full Text] [PDF]   Cecelia C. Yates, Diana Whaley, Amy Y-Chen, Priya Kulesekaran, Patricia A. Hebda, and Alan Wells ELR-Negative CXC Chemokine CXCL11 (IP-9/I-TAC) Facilitates Dermal and Epidermal Maturation during Wound Repair Am J Pathol 2008 173: 643-652. First published online July 31, 2008; doi:10.2353/ajpath.2008.070990 [Abstract] [Full Text] [PDF]   Akitoshi Nakashima, Arihiro Shiozaki, Subaru Myojo, Mika Ito, Mikiko Tatematsu, Masatoshi Sakai, Yasushi Takamori, Kazuyuki Ogawa, Kinya Nagata, and Shigeru Saito Granulysin Produced by Uterine Natural Killer Cells Induces Apoptosis of Extravillous Trophoblasts in Spontaneous Abortion Am J Pathol 2008 173: 653-664. First published online August 7, 2008; doi:10.2353/ajpath.2008.071169 [Abstract] [Full Text] [PDF]   Dun-Sheng Yang, Asok Kumar, Philip Stavrides, Jesse Peterson, Corrine M. Peterhoff, Monika Pawlik, Efrat Levy, Anne M. Cataldo, and Ralph A. Nixon Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer’s Disease Am J Pathol 2008 173: 665-681. First published online August 7, 2008; doi:10.2353/ajpath.2008.071176 [Abstract] [Full Text] [PDF] Supplemental Material

Epithelial and Mesenchymal Cell Biology: Ewa Krawczyk, Frank A. Suprynowicz, Xuefeng Liu, Yuhai Dai, Dan P. Hartmann, John Hanover, and Richard Schlegel Koilocytosis: A Cooperative Interaction between the Human Papillomavirus E5 and E6 Oncoproteins Am J Pathol 2008 173: 682-688. First published online August 7, 2008; doi:10.2353/ajpath.2008.080280 [Abstract] [Full Text] [PDF]   Peter M. Elias, Jack Arbiser, Barbara E. Brown, Heidemarie Rossiter, Mao-Qiang Man, Francesca Cerimele, Debra Crumrine, Roshan Gunathilake, Eung Ho Choi, Yoshikazu Uchida, Erwin Tschachler, and Kenneth R. Feingold Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia: Implications for the Pathogenesis of Psoriasis Am J Pathol 2008 173: 689-699. First published online August 7, 2008; doi:10.2353/ajpath.2008.080088 [Abstract] [Full Text] [PDF]

Growth Factors, Cytokines, Cell Cycle Molecules: M. Louise Hull, Claudia Rangel Escareno, Jane M. Godsland, John R. Doig, Claire M. Johnson, Stephen C. Phillips, Stephen K. Smith, Simon Tavaré, Cristin G. Print, and D. Stephen Charnock-Jones Endometrial-Peritoneal Interactions during Endometriotic Lesion Establishment Am J Pathol 2008 173: 700-715. First published online August 7, 2008; doi:10.2353/ajpath.2008.071128 [Abstract] [Full Text] [PDF] Supplemental Material   Al-karim Khimji, Rong Shao, and Don C. Rockey Divergent Transforming Growth Factor-β Signaling in Hepatic Stellate Cells after Liver Injury: Functional Effects on ECE-1 Regulation Am J Pathol 2008 173: 716-727. ; doi: 10.2353/ajpath.2008.071121 [Abstract] [Full Text] [PDF] Supplemental Material

Immunopathology and Infectious Disease: Monisha Dhiman, Ernesto Satoshi Nakayasu, Yashoda Hosakote Madaiah, Brobey K. Reynolds, Jian-jun Wen, Igor Correia Almeida, and Nisha Jain Garg Enhanced Nitrosative Stress during Trypanosoma cruzi Infection Causes Nitrotyrosine Modification of Host Proteins: Implications in Chagas’ Disease Am J Pathol 2008 173: 728-740. First published online August 7, 2008; doi:10.2353/ajpath.2008.080047 [Abstract] [Full Text] [PDF]   Luciana Benevides, Cristiane Maria Milanezi, Lucy Megumi Yamauchi, Cláudia Farias Benjamim, João Santana Silva, and Neide Maria Silva CCR2 Receptor Is Essential to Activate Microbicidal Mechanisms to Control Toxoplasma gondii Infection in the Central Nervous System Am J Pathol 2008 173: 741-751. First published online August 7, 2008; doi:10.2353/ajpath.2008.080129 [Abstract] [Full Text] [PDF]

Molecular Pathogenesis of Genetic and Inherited Diseases: Li-Hong Gu and Pierre A. Coulombe Hedgehog Signaling, Keratin 6 Induction, and Sebaceous Gland Morphogenesis: Implications for Pachyonychia Congenita and Related Conditions Am J Pathol 2008 173: 752-761. First published online August 7, 2008; doi:10.2353/ajpath.2008.071089 [Abstract] [Full Text] [PDF] Supplemental Material   Jennifer B. Paulson, Martin Ramsden, Colleen Forster, Mathew A. Sherman, Eileen McGowan, and Karen H. Ashe Amyloid Plaque and Neurofibrillary Tangle Pathology in a Regulatable Mouse Model of Alzheimer’s Disease Am J Pathol 2008 173: 762-772. First published online July 31, 2008; doi:10.2353/ajpath.2008.080175 [Abstract] [Full Text] [PDF]

Musculoskeletal Pathology: Nadeem Samee, Valerie Geoffroy, Caroline Marty, Corinne Schiltz, Maxence Vieux-Rochas, Giovanni Levi, and Marie-Christine de Vernejoul Dlx5, a Positive Regulator of Osteoblastogenesis, is Essential for Osteoblast-Osteoclast Coupling Am J Pathol 2008 173: 773-780. First published online July 31, 2008; doi:10.2353/ajpath.2008.080243 [Abstract] [Full Text] [PDF]   Norio Motohashi, Akiyoshi Uezumi, Erica Yada, So-ichiro Fukada, Kazuhiro Fukushima, Kazuhiko Imaizumi, Yuko Miyagoe-Suzuki, and Shin'ichi Takeda Muscle CD31(–) CD45(–) Side Population Cells Promote Muscle Regeneration by Stimulating Proliferation and Migration of Myoblasts Am J Pathol 2008 173: 781-791. First published online July 31, 2008; doi:10.2353/ajpath.2008.070902 [Abstract] [Full Text] [PDF] Supplemental Material

Stem Cells, Tissue Engineering and Hematopoietic Elements: Gregory Q. Wallace, Karen A. Lapidos, Jordan S. Kenik, and Elizabeth M. McNally Long-Term Survival of Transplanted Stem Cells in Immunocompetent Mice with Muscular Dystrophy Am J Pathol 2008 173: 792-802. First published online August 18, 2008; doi:10.2353/ajpath.2008.080259 [Abstract] [Full Text] [PDF]   Takenao Chino, Katsuto Tamai, Takehiko Yamazaki, Satoru Otsuru, Yasushi Kikuchi, Keisuke Nimura, Masayuki Endo, Miki Nagai, Jouni Uitto, Yasuo Kitajima, and Yasufumi Kaneda Bone Marrow Cell Transfer into Fetal Circulation Can Ameliorate Genetic Skin Diseases by Providing Fibroblasts to the Skin and Inducing Immune Tolerance Am J Pathol 2008 173: 803-814. First published online August 7, 2008; doi:10.2353/ajpath.2008.070977 [Abstract] [Full Text] [PDF] Supplemental Material   Geuranne Tjabringa, Mieke Bergers, Desiree van Rens, Roelie de Boer, Evert Lamme, and Joost Schalkwijk Development and Validation of Human Psoriatic Skin Equivalents Am J Pathol 2008 173: 815-823. First published online July 31, 2008; doi:10.2353/ajpath.2008.080173 [Abstract] [Full Text] [PDF]

Tumorigenesis and Neoplastic Progression: Krisztina Kovács de Ostrovich, Isabel Lambertz, Jennifer K. L. Colby, Jie Tian, Joyce E. Rundhaug, Dennis Johnston, Claudio J. Conti, John DiGiovanni, and Robin Fuchs-Young Paracrine Overexpression of Insulin-Like Growth Factor-1 Enhances Mammary Tumorigenesis in Vivo Am J Pathol 2008 173: 824-834. First published online August 7, 2008; doi:10.2353/ajpath.2008.071005 [Abstract] [Full Text] [PDF]   Keiji Tanese, Mariko Fukuma, Taketo Yamada, Taisuke Mori, Tsutomu Yoshikawa, Wakako Watanabe, Akira Ishiko, Masayuki Amagai, Takeji Nishikawa, and Michiie Sakamoto G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation Am J Pathol 2008 173: 835-843. First published online August 7, 2008; doi:10.2353/ajpath.2008.071091 [Abstract] [Full Text] [PDF] Supplemental Material   Silvia Goldoni, Daniela G. Seidler, Jack Heath, Matteo Fassan, Raffaele Baffa, Mathew L. Thakur, Rick T. Owens, David J. McQuillan, and Renato V. Iozzo An Antimetastatic Role for Decorin in Breast Cancer Am J Pathol 2008 173: 844-855. First published online August 7, 2008; doi:10.2353/ajpath.2008.080275 [Abstract] [Full Text] [PDF] Supplemental Material   Erin Connolly, Margherita Melegari, Pablo Landgraf, Tatyana Tchaikovskaya, Bud C. Tennant, Betty L. Slagle, Leslie E. Rogler, Mihaela Zavolan, Thomas Tuschl, and Charles E. Rogler Elevated Expression of the miR-17–92 Polycistron and miR-21 in Hepadnavirus-Associated Hepatocellular Carcinoma Contributes to the Malignant Phenotype Am J Pathol 2008 173: 856-864. First published online August 7, 2008; doi:10.2353/ajpath.2008.080096 [Abstract] [Full Text] [PDF] Supplemental Material   Sumithra Urs, Alice Roudabush, Christine F. O'Neill, Ilka Pinz, Igor Prudovsky, Doreen Kacer, Yuefang Tang, Lucy Liaw, and Deena Small Soluble Forms of the Notch Ligands Delta1 and Jagged1 Promote in Vivo Tumorigenicity in NIH3T3 Fibroblasts with Distinct Phenotypes Am J Pathol 2008 173: 865-878. First published online August 7, 2008; doi:10.2353/ajpath.2008.080006 [Abstract] [Full Text] [PDF]

Vascular Biology, Atherosclerosis and Endothelium Biology: Marie M. Krady, Jianmin Zeng, Jun Yu, Susan MacLauchlan, Eleni A. Skokos, Weiming Tian, Paul Bornstein, William C. Sessa, and Themis R. Kyriakides Thrombospondin-2 Modulates Extracellular Matrix Remodeling during Physiological Angiogenesis Am J Pathol 2008 173: 879-891. First published online August 7, 2008; doi:10.2353/ajpath.2008.080128 [Abstract] [Full Text] [PDF] Supplemental Material   Rajkumar Noubade, Roxana del Rio, Benjamin McElvany, James F. Zachary, Jason M. Millward, Denisa D. Wagner, Halina Offner, Elizabeth P. Blankenhorn, and Cory Teuscher Von-Willebrand Factor Influences Blood Brain Barrier Permeability and Brain Inflammation in Experimental Allergic Encephalomyelitis Am J Pathol 2008 173: 892-900. First published online August 7, 2008; doi:10.2353/ajpath.2008.080001 [Abstract] [Full Text] [PDF]   Ying Tian, Laura J. Sommerville, Anthony Cuneo, Sheri E. Kelemen, and Michael V. Autieri Expression and Suppressive Effects of Interleukin-19 on Vascular Smooth Muscle Cell Pathophysiology and Development of Intimal Hyperplasia Am J Pathol 2008 173: 901-909. First published online July 31, 2008; doi:10.2353/ajpath.2008.080163 [Abstract] [Full Text] [PDF]

Correspondence: Hans U. Lutz Alternative Complement Pathway Induction by ANCA Am J Pathol 2008 173: 910. First published online August 7, 2008; doi:10.2353/ajpath.2008.080406 [Abstract] [Full Text] [PDF]

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