Commentaries: Ie-Ming Shih and Kuan-Ting Kuo Power of the Eternal Youth: Nanog Expression in the Gestational Choriocarcinoma Am J Pathol 2008 173: 911-914. First published online August 28, 2008; doi:10.2353/ajpath.2008.080624 [Abstract] [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Maria Carolina Gongora, Heinrich E. Lob, Ulf Landmesser, Tomasz J. Guzik, W. David Martin, Kiyoski Ozumi, Susan M. Wall, David Scott Wilson, Niren Murthy, Michael Gravanis, Tohru Fukai, and David G. Harrison Loss of Extracellular Superoxide Dismutase Leads to Acute Lung Damage in the Presence of Ambient Air: A Potential Mechanism Underlying Adult Respiratory Distress Syndrome Am J Pathol 2008 173: 915-926. First published online September 11, 2008; doi:10.2353/ajpath.2008.080119 [Abstract] [Full Text] [PDF] Supplemental Material   Rosa M. Baleato, Petrina L. Guthrie, Marie-Claire Gubler, Leonie K. Ashman, and Séverine Roselli Deletion of Cd151 Results in a Strain-Dependent Glomerular Disease Due to Severe Alterations of the Glomerular Basement Membrane Am J Pathol 2008 173: 927-937. First published online September 11, 2008; doi:10.2353/ajpath.2008.071149 [Abstract] [Full Text] [PDF]   Rebecca R. Foster, Sadie C. Slater, Jaqualine Seckley, Dontscho Kerjaschki, David O. Bates, Peter W. Mathieson, and Simon C. Satchell Vascular Endothelial Growth Factor-C, a Potential Paracrine Regulator of Glomerular Permeability, Increases Glomerular Endothelial Cell Monolayer Integrity and Intracellular Calcium Am J Pathol 2008 173: 938-948. First published online September 4, 2008; doi:10.2353/ajpath.2008.070416 [Abstract] [Full Text] [PDF] Open Choice Article   Jennifer G. McComb, Mrunalini Ranganathan, Xiang Hong Liu, Joseph M. Pilewski, Prabir Ray, Simon C. Watkins, Augustine M.K. Choi, and Janet S. Lee CX3CL1 Up-Regulation Is Associated with Recruitment of CX3CR1+ Mononuclear Phagocytes and T Lymphocytes in the Lungs during Cigarette Smoke-Induced Emphysema Am J Pathol 2008 173: 949-961. First published online September 4, 2008; doi:10.2353/ajpath.2008.071034 [Abstract] [Full Text] [PDF]

Cell Injury, Repair, Aging and Apoptosis: Hong-Min Ni, Xiaoyun Chen, Wen-Xing Ding, Marcus Schuchmann, and Xiao-Ming Yin Differential Roles of JNK in ConA/GalN and ConA-Induced Liver Injury in Mice Am J Pathol 2008 173: 962-972. First published online September 4, 2008; doi:10.2353/ajpath.2008.080358 [Abstract] [Full Text] [PDF]   Xiufen Zheng, Xusheng Zhang, Biao Feng, Hongtao Sun, Motohiko Suzuki, Thomas Ichim, Norihiko Kubo, Arthur Wong, Lisa R. Min, Marianne E. Budohn, Bertha Garcia, Anthony M. Jevnikar, and Wei-Ping Min Gene Silencing of Complement C5a Receptor Using siRNA for Preventing Ischemia/Reperfusion Injury Am J Pathol 2008 173: 973-980. First published online September 4, 2008; doi:10.2353/ajpath.2008.080103 [Abstract] [Full Text] [PDF]   Abdelhamid Almolki, Armelle Guenegou, Slawomir Golda, Laurent Boyer, Mourad Benallaoua, Nadia Amara, Rafik Bachoual, Clémence Martin, François Rannou, Sophie Lanone, Jozef Dulak, Pierre-Régis Burgel, Jamel El-Benna, A. Benedicte Leynaert, Michel Aubier, and Jorge Boczkowski Heme Oxygenase-1 Prevents Airway Mucus Hypersecretion Induced by Cigarette Smoke in Rodents and Humans Am J Pathol 2008 173: 981-992. First published online September 11, 2008; doi:10.2353/ajpath.2008.070863 [Abstract] [Full Text] [PDF]

Gastrointestinal, Hepatobiliary and Pancreatic Pathology: Laurie D. DeLeve, Xiangdong Wang, Gary C. Kanel, Roscoe D. Atkinson, and Robert S. McCuskey Prevention of Hepatic Fibrosis in a Murine Model of Metabolic Syndrome with Nonalcoholic Steatohepatitis Am J Pathol 2008 173: 993-1001. First published online September 4, 2008; doi:10.2353/ajpath.2008.070720 [Abstract] [Full Text] [PDF]   Ningling Kang Decker, Soha S. Abdelmoneim, Usman Yaqoob, Helen Hendrickson, Joe Hormes, Mike Bentley, Henry Pitot, Raul Urrutia, Greg J. Gores, and Vijay H. Shah Nitric Oxide Regulates Tumor Cell Cross-Talk with Stromal Cells in the Tumor Microenvironment of the Liver Am J Pathol 2008 173: 1002-1012. First published online August 28, 2008; doi:10.2353/ajpath.2008.080158 [Abstract] [Full Text] [PDF]   Yutao Yan, Guillaume Dalmasso, Hang Thi Thu Nguyen, Tracy S. Obertone, Laetitia Charrier-Hisamuddin, Shanthi V. Sitaraman, and Didier Merlin Nuclear Factor-B Is a Critical Mediator of Ste20-Like Proline-/Alanine-Rich Kinase Regulation in Intestinal Inflammation Am J Pathol 2008 173: 1013-1028. First published online September 11, 2008; doi:10.2353/ajpath.2008.080339 [Abstract] [Full Text] [PDF] Supplemental Material

Growth Factors, Cytokines, Cell Cycle Molecules: Shigeki Tsutsui, Jennifer N. Hahn, Trina A. Johnson, Zenobia Ali, and Frank R. Jirik Absence of the Cellular Prion Protein Exacerbates and Prolongs Neuroinflammation in Experimental Autoimmune Encephalomyelitis Am J Pathol 2008 173: 1029-1041. ; doi: 10.2353/ajpath.2008.071062 [Abstract] [Full Text] [PDF] Supplemental Material   Aleksander Hinek, Tetyana D. Bodnaruk, Severa Bunda, Yanting Wang, and Kela Liu Neuraminidase-1, a Subunit of the Cell Surface Elastin Receptor, Desialylates and Functionally Inactivates Adjacent Receptors Interacting with the Mitogenic Growth Factors PDGF-BB and IGF-2 Am J Pathol 2008 173: 1042-1056. First published online September 4, 2008; doi:10.2353/ajpath.2008.071081 [Abstract] [Full Text] [PDF]

Immunopathology and Infectious Disease: Christos Marantos, Violet Mukaro, Judith Ferrante, Charles Hii, and Antonio Ferrante Inhibition of the Lipopolysaccharide-Induced Stimulation of the Members of the MAPK Family in Human Monocytes/Macrophages by 4-Hydroxynonenal, a Product of Oxidized Omega-6 Fatty Acids Am J Pathol 2008 173: 1057-1066. First published online September 4, 2008; doi:10.2353/ajpath.2008.071150 [Abstract] [Full Text] [PDF]   Cornelia Doebis, Kerstin Siegmund, Christoph Loddenkemper, John B. Lowe, Andrew C. Issekutz, Alf Hamann, Jochen Huehn, and Uta Syrbe Cellular Players and Role of Selectin Ligands in Leukocyte Recruitment in a T-Cell-Initiated Delayed-Type Hypersensitivity Reaction Am J Pathol 2008 173: 1067-1076. First published online August 28, 2008; doi:10.2353/ajpath.2008.080052 [Abstract] [Full Text] [PDF]   Wei Wang, Hauting Yen, Chih-Hung Chen, Rimabahen Soni, Nitesh Jasani, Georges Sylvestre, and Sandra E. Reznik The Endothelin-Converting Enzyme-1/Endothelin-1 Pathway Plays a Critical Role in Inflammation-Associated Premature Delivery in a Mouse Model Am J Pathol 2008 173: 1077-1084. First published online September 4, 2008; doi:10.2353/ajpath.2008.080257 [Abstract] [Full Text] [PDF]

Matrix Pathobiology: Swati Bhattacharyya, Shu-Jen Chen, Minghua Wu, Matthew Warner-Blankenship, Hongyan Ning, Gabriella Lakos, Yasuji Mori, Eric Chang, Chihiro Nihijima, Kazuhiro Takehara, Carol Feghali-Bostwick, and John Varga Smad-Independent Transforming Growth Factor-β Regulation of Early Growth Response-1 and Sustained Expression in Fibrosis: Implications for Scleroderma Am J Pathol 2008 173: 1085-1099. First published online September 4, 2008; doi:10.2353/ajpath.2008.080382 [Abstract] [Full Text] [PDF]   Jeff S. Isenberg, Justin B. Maxhimer, Fuminori Hyodo, Michael L. Pendrak, Lisa A. Ridnour, William G. DeGraff, Maria Tsokos, David A. Wink, and David D. Roberts Thrombospondin-1 and CD47 Limit Cell and Tissue Survival of Radiation Injury Am J Pathol 2008 173: 1100-1112. First published online September 11, 2008; doi:10.2353/ajpath.2008.080237 [Abstract] [Full Text] [PDF] Supplemental Material

Molecular Pathogenesis of Genetic and Inherited Diseases: Eugene A. de Zwart-Storm, Michel van Geel, Pierre A.F.A. van Neer, Peter M. Steijlen, Patricia E. Martin, and Maurice A.M. van Steensel A Novel Missense Mutation in the Second Extracellular Domain of GJB2, p.Ser183Phe, Causes a Syndrome of Focal Palmoplantar Keratoderma with Deafness Am J Pathol 2008 173: 1113-1119. First published online September 11, 2008; doi:10.2353/ajpath.2008.080049 [Abstract] [Full Text] [PDF]   Carla Giordano, Mariangela Sebastiani, Roberto De Giorgio, Claudia Travaglini, Andrea Tancredi, Maria Lucia Valentino, Marzio Bellan, Andrea Cossarizza, Michio Hirano, Giulia d'Amati, and Valerio Carelli Gastrointestinal Dysmotility in Mitochondrial Neurogastrointestinal Encephalomyopathy Is Caused by Mitochondrial DNA Depletion Am J Pathol 2008 173: 1120-1128. First published online September 11, 2008; doi:10.2353/ajpath.2008.080252 [Abstract] [Full Text] [PDF]

Neurobiology: Byungki Jang, Eunah Kim, Jin-Kyu Choi, Jae-Kwang Jin, Jae-Il Kim, Akihito Ishigami, Naoki Maruyama, Richard I. Carp, Yong-Sun Kim, and Eun-Kyoung Choi Accumulation of Citrullinated Proteins by Up-Regulated Peptidylarginine Deiminase 2 in Brains of Scrapie-Infected Mice: A Possible Role in Pathogenesis Am J Pathol 2008 173: 1129-1142. First published online September 11, 2008; doi:10.2353/ajpath.2008.080388 [Abstract] [Full Text] [PDF]   Veronique E. Miron, Jeffery A. Hall, Timothy E. Kennedy, Betty Soliven, and Jack P. Antel Cyclical and Dose-Dependent Responses of Adult Human Mature Oligodendrocytes to Fingolimod Am J Pathol 2008 173: 1143-1152. First published online September 4, 2008; doi:10.2353/ajpath.2008.080478 [Abstract] [Full Text] [PDF] Supplemental Material

Tumorigenesis and Neoplastic Progression: Wenlin Du, Nobumichi Hozumi, Michiie Sakamoto, Jun-ichi Hata, and Taketo Yamada Reconstitution of Schwannian Stroma in Neuroblastomas Using Human Bone Marrow Stromal Cells Am J Pathol 2008 173: 1153-1164. First published online September 4, 2008; doi:10.2353/ajpath.2008.070309 [Abstract] [Full Text] [PDF] Supplemental Material   Michelle K.Y. Siu, Esther S.Y. Wong, Hoi Yan Chan, Hextan Y.S. Ngan, Kelvin Y.K. Chan, and Annie N.Y. Cheung Overexpression of NANOG in Gestational Trophoblastic Diseases: Effect on Apoptosis, Cell Invasion, and Clinical Outcome Am J Pathol 2008 173: 1165-1172. First published online September 4, 2008; doi:10.2353/ajpath.2008.080288 [Abstract] [Full Text] [PDF]   Ruslan Hlushchuk, Oliver Riesterer, Oliver Baum, Jeanette Wood, Guenther Gruber, Martin Pruschy, and Valentin Djonov Tumor Recovery by Angiogenic Switch from Sprouting to Intussusceptive Angiogenesis after Treatment with PTK787/ZK222584 or Ionizing Radiation Am J Pathol 2008 173: 1173-1185. First published online September 11, 2008; doi:10.2353/ajpath.2008.071131 [Abstract] [Full Text] [PDF]   Elena Favaro, Giorgia Nardo, Luca Persano, Massimo Masiero, Lidia Moserle, Rita Zamarchi, Elisabetta Rossi, Giovanni Esposito, Mario Plebani, Ulrike Sattler, Thomas Mann, Wolfgang Mueller-Klieser, Vincenzo Ciminale, Alberto Amadori, and Stefano Indraccolo Hypoxia Inducible Factor-1 Inactivation Unveils a Link between Tumor Cell Metabolism and Hypoxia-Induced Cell Death Am J Pathol 2008 173: 1186-1201. First published online September 4, 2008; doi:10.2353/ajpath.2008.071183 [Abstract] [Full Text] [PDF] Supplemental Material

Vascular Biology, Atherosclerosis and Endothelium Biology: Nikolaus Wick, Daniela Haluza, Elisabeth Gurnhofer, Ingrid Raab, Marie-Theres Kasimir, Michael Prinz, Carl-Walter Steiner, Christina Reinisch, Anny Howorka, Pietro Giovanoli, Sabine Buchsbaum, Sigurd Krieger, Erwin Tschachler, Peter Petzelbauer, and Dontscho Kerjaschki Lymphatic Precollectors Contain a Novel, Specialized Subpopulation of Podoplaninlow, CCL27-Expressing Lymphatic Endothelial Cells Am J Pathol 2008 173: 1202-1209. First published online September 4, 2008; doi:10.2353/ajpath.2008.080101 [Abstract] [Full Text] [PDF]   Abdelali Agouni, Anne Hélène Lagrue-Lak-Hal, Pierre Henri Ducluzeau, Hadj Ahmed Mostefai, Catherine Draunet-Busson, Georges Leftheriotis, Christophe Heymes, Maria Carmen Martinez, and Ramaroson Andriantsitohaina Endothelial Dysfunction Caused by Circulating Microparticles from Patients with Metabolic Syndrome Am J Pathol 2008 173: 1210-1219. First published online September 4, 2008; doi:10.2353/ajpath.2008.080228 [Abstract] [Full Text] [PDF]   Christopher R. Anderson, Nicole E. Hastings, Brett R. Blackman, and Richard J. Price Capillary Sprout Endothelial Cells Exhibit a CD36low Phenotype: Regulation by Shear Stress and Vascular Endothelial Growth Factor-Induced Mechanism for Attenuating Anti-Proliferative Thrombospondin-1 Signaling Am J Pathol 2008 173: 1220-1228. First published online September 4, 2008; doi:10.2353/ajpath.2008.071194 [Abstract] [Full Text] [PDF]   Axel M. Küchler, Jürgen Pollheimer, Johanna Balogh, Jon Sponheim, Linda Manley, Dag R. Sorensen, Paula M. De Angelis, Helge Scott, and Guttorm Haraldsen Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation Am J Pathol 2008 173: 1229-1242. First published online September 11, 2008; doi:10.2353/ajpath.2008.080014 [Abstract] [Full Text] [PDF] Supplemental Material

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