Reviews: Christine Korteweg and Jiang Gu Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans Am J Pathol 2008 172: 1155-1170. First published online April 10, 2008; doi:10.2353/ajpath.2008.070791 [Abstract] [Full Text] [PDF]

Commentaries: Mitchell P. Fink Neuropeptide Modulators of High Mobility Group Box 1 Secretion as Potential Therapeutic Agents for Severe Sepsis Am J Pathol 2008 172: 1171-1173. First published online April 10, 2008; doi:10.2353/ajpath.2008.080161 [Abstract] [Full Text] [PDF]

Regular Articles:

Cardiovascular, Pulmonary and Renal Pathology: Vijay Koka, Xiao Ru Huang, Arthur C.K. Chung, Wansheng Wang, Luan D. Truong, and Hui Yao Lan Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway Am J Pathol 2008 172: 1174-1183. First published online April 10, 2008; doi:10.2353/ajpath.2008.070762 [Abstract] [Full Text] [PDF]   Emilie Boncoeur, Telma Roque, Elise Bonvin, Vinciane Saint-Criq, Monique Bonora, Annick Clement, Olivier Tabary, Alexandra Henrion-Caude, and Jacky Jacquot Cystic Fibrosis Transmembrane Conductance Regulator Controls Lung Proteasomal Degradation and Nuclear Factor-B Activity in Conditions of Oxidative Stress Am J Pathol 2008 172: 1184-1194. First published online March 27, 2008; doi:10.2353/ajpath.2008.070310 [Abstract] [Full Text] [PDF]   Daniela Cihakova, Jobert G. Barin, Marina Afanasyeva, Miho Kimura, DeLisa Fairweather, Michael Berg, Monica V. Talor, G. Christian Baldeviano, Sylvia Frisancho, Kathleen Gabrielson, Djahida Bedja, and Noel R. Rose Interleukin-13 Protects Against Experimental Autoimmune Myocarditis by Regulating Macrophage Differentiation Am J Pathol 2008 172: 1195-1208. First published online April 10, 2008; doi:10.2353/ajpath.2008.070207 [Abstract] [Full Text] [PDF] Supplemental Material   Glenda Trujillo, Erica C. O’Connor, Steven L. Kunkel, and Cory M. Hogaboam A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis Am J Pathol 2008 172: 1209-1221. First published online April 10, 2008; doi:10.2353/ajpath.2008.070832 [Abstract] [Full Text] [PDF]   Hongwei Yao, Indika Edirisinghe, Se-Ran Yang, Saravanan Rajendrasozhan, Aruna Kode, Samuel Caito, David Adenuga, and Irfan Rahman Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice Am J Pathol 2008 172: 1222-1237. First published online April 10, 2008; doi:10.2353/ajpath.2008.070765 [Abstract] [Full Text] [PDF]

Cell Injury, Repair, Aging and Apoptosis: Gaelle del Castillo, Valentina M. Factor, Margarita Fernández, Alberto Álvarez-Barrientos, Isabel Fabregat, Snorri S. Thorgeirsson, and Aránzazu Sánchez Deletion of the Met Tyrosine Kinase in Liver Progenitor Oval Cells Increases Sensitivity to Apoptosis in Vitro Am J Pathol 2008 172: 1238-1247. First published online April 1, 2008; doi:10.2353/ajpath.2008.070793 [Abstract] [Full Text] [PDF] Supplemental Material   Simin Arad, Edoardo Zattra, Jennifer Hebert, Ervin H. Epstein, Jr., David A. Goukassian, and Barbara A. Gilchrest Topical Thymidine Dinucleotide Treatment Reduces Development of Ultraviolet-Induced Basal Cell Carcinoma in Ptch-1+/– Mice Am J Pathol 2008 172: 1248-1255. First published online April 10, 2008; doi:10.2353/ajpath.2008.071117 [Abstract] [Full Text] [PDF] Supplemental Material

Epithelial and Mesenchymal Cell Biology: Peter Chen, John K. McGuire, Robert C. Hackman, Kyoung-Hee Kim, Roy A. Black, Kurt Poindexter, Wei Yan, Phillip Liu, Ann J. Chen, William C. Parks, and David K. Madtes Tissue Inhibitor of Metalloproteinase-1 Moderates Airway Re-Epithelialization by Regulating Matrilysin Activity Am J Pathol 2008 172: 1256-1270. First published online April 1, 2008; doi:10.2353/ajpath.2008.070891 [Abstract] [Full Text] [PDF] Supplemental Material   Farzin Ghannad, Daniela Nica, Maria I. Garcia Fulle, Daniel Grenier, Edward E. Putnins, Sarah Johnston, Ameneh Eslami, Leeni Koivisto, Guoqiao Jiang, Marc D. McKee, Lari Häkkinen, and Hannu Larjava Absence of vβ6 Integrin Is Linked to Initiation and Progression of Periodontal Disease Am J Pathol 2008 172: 1271-1286. First published online April 1, 2008; doi:10.2353/ajpath.2008.071068 [Abstract] [Full Text] [PDF]   Nicolas Genoud, David Ott, Nathalie Braun, Marco Prinz, Petra Schwarz, Ueli Suter, Didier Trono, and Adriano Aguzzi Antiprion Prophylaxis by Gene Transfer of a Soluble Prion Antagonist Am J Pathol 2008 172: 1287-1296. First published online March 27, 2008; doi:10.2353/ajpath.2008.070836 [Abstract] [Full Text] [PDF] Supplemental Material

Growth Factors, Cytokines, Cell Cycle Molecules: Alejo Chorny and Mario Delgado Neuropeptides Rescue Mice from Lethal Sepsis by Down-regulating Secretion of the Late-Acting Inflammatory Mediator High Mobility Group Box 1 Am J Pathol 2008 172: 1297-1307. First published online April 1, 2008; doi:10.2353/ajpath.2008.070969 [Abstract] [Full Text] [PDF]   Daudi L. Langat, David A. Wheaton, Jeralyn Sue Platt, Travis Sifers, and Joan S. Hunt Signaling Pathways for B Cell-Activating Factor (BAFF) and a Proliferation-Inducing Ligand (APRIL) in Human Placenta Am J Pathol 2008 172: 1303-1311. First published online April 10, 2008; doi:10.2353/ajpath.2008.071139 [Abstract] [Full Text] [PDF]

Metabolic, Endocrine and Genitourinary Pathobiology: Maryla Krajewska, Steven Banares, Eric E. Zhang, Xianshu Huang, Miriam Scadeng, Ulupi S. Jhala, Gen-Sheng Feng, and Stan Krajewski Development of Diabesity in Mice with Neuronal Deletion of Shp2 Tyrosine Phosphatase Am J Pathol 2008 172: 1312-1324. First published online April 10, 2008; doi:10.2353/ajpath.2008.070594 [Abstract] [Full Text] [PDF]   Kouhei Hashizume, Manabu Hirasawa, Yutaka Imamura, Setsuko Noda, Takahiko Shimizu, Kei Shinoda, Toshihide Kurihara, Kousuke Noda, Yoko Ozawa, Susumu Ishida, Yozo Miyake, Takuji Shirasawa, and Kazuo Tsubota Retinal Dysfunction and Progressive Retinal Cell Death in SOD1-Deficient Mice Am J Pathol 2008 172: 1325-1331. First published online March 27, 2008; doi:10.2353/ajpath.2008.070730 [Abstract] [Full Text] [PDF]

Molecular Pathogenesis of Genetic and Inherited Diseases: Dejia Li, Yongping Yue, and Dongsheng Duan Preservation of Muscle Force in Mdx3cv Mice Correlates with Low-Level Expression of a Near Full-Length Dystrophin Protein Am J Pathol 2008 172: 1332-1341. First published online April 1, 2008; doi:10.2353/ajpath.2008.071042 [Abstract] [Full Text] [PDF] Supplemental Material

Neurobiology: Salim S. El-Amouri, Hong Zhu, Jin Yu, Robert Marr, Inder M. Verma, and Mark S. Kindy Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer’s Disease Am J Pathol 2008 172: 1342-1354. First published online April 10, 2008; doi:10.2353/ajpath.2008.070620 [Abstract] [Full Text] [PDF]   Rohini Polavarapu, Jie An, Chen Zhang, and Manuel Yepes Regulated Intramembrane Proteolysis of the Low-Density Lipoprotein Receptor-Related Protein Mediates Ischemic Cell Death Am J Pathol 2008 172: 1355-1362. First published online April 10, 2008; doi:10.2353/ajpath.2008.070975 [Abstract] [Full Text] [PDF]

Tumorigenesis and Neoplastic Progression: Claudia Gaspar, Joana Cardoso, Patrick Franken, Lia Molenaar, Hans Morreau, Gabriela Möslein, Julian Sampson, Judith M. Boer, Renée X. de Menezes, and Riccardo Fodde Cross-Species Comparison of Human and Mouse Intestinal Polyps Reveals Conserved Mechanisms in Adenomatous Polyposis Coli (APC)-Driven Tumorigenesis Am J Pathol 2008 172: 1363-1380. First published online April 10, 2008; doi:10.2353/ajpath.2008.070851 [Abstract] [Full Text] [PDF] Supplemental Material   Rajendra Bhati, Cam Patterson, Chad A. Livasy, Cheng Fan, David Ketelsen, Zhiyuan Hu, Evangeline Reynolds, Catherine Tanner, Dominic T. Moore, Franco Gabrielli, Charles M. Perou, and Nancy Klauber-DeMore Molecular Characterization of Human Breast Tumor Vascular Cells Am J Pathol 2008 172: 1381-1390. First published online April 10, 2008; doi:10.2353/ajpath.2008.070988 [Abstract] [Full Text] [PDF] Supplemental Material   Michael Herfs, Pascale Hubert, Natalia Kholod, Jean Hubert Caberg, Christine Gilles, Geert Berx, Pierre Savagner, Jacques Boniver, and Philippe Delvenne Transforming Growth Factor-β1-Mediated Slug and Snail Transcription Factor Up-Regulation Reduces the Density of Langerhans Cells in Epithelial Metaplasia by Affecting E-Cadherin Expression Am J Pathol 2008 172: 1391-1402. First published online April 1, 2008; doi:10.2353/ajpath.2008.071004 [Abstract] [Full Text] [PDF]   Jennelle C. Hodge, Bradley J. Quade, Mark A. Rubin, Elizabeth A. Stewart, Paola Dal Cin, and Cynthia C. Morton Molecular and Cytogenetic Characterization of Plexiform Leiomyomata Provide Further Evidence for Genetic Heterogeneity Underlying Uterine Fibroids Am J Pathol 2008 172: 1403-1410. First published online April 10, 2008; doi:10.2353/ajpath.2008.071102 [Abstract] [Full Text] [PDF] Supplemental Material

Vascular Biology, Atherosclerosis and Endothelium Biology: Yugal Behl, Padmaja Krothapalli, Tesfahun Desta, Amanda DiPiazza, Sayon Roy, and Dana T. Graves Diabetes-Enhanced Tumor Necrosis Factor- Production Promotes Apoptosis and the Loss of Retinal Microvascular Cells in Type 1 and Type 2 Models of Diabetic Retinopathy Am J Pathol 2008 172: 1411-1418. First published online April 10, 2008; doi:10.2353/ajpath.2008.071070 [Abstract] [Full Text] [PDF] Supplemental Material   Sohsuke Yamada, Ke-Yong Wang, Akihide Tanimoto, Jianglin Fan, Shohei Shimajiri, Shuji Kitajima, Masatoshi Morimoto, Masato Tsutsui, Teruo Watanabe, Kosei Yasumoto, and Yasuyuki Sasaguri Matrix Metalloproteinase 12 Accelerates the Initiation of Atherosclerosis and Stimulates the Progression of Fatty Streaks to Fibrous Plaques in Transgenic Rabbits Am J Pathol 2008 172: 1419-1429. First published online April 10, 2008; doi:10.2353/ajpath.2008.070604 [Abstract] [Full Text] [PDF]   Sandrine Delbosc, Martine Glorian, Anne-Sophie Le Port, Gilbert Béréziat, Marise Andréani, and Isabelle Limon The Benefit of Docosahexanoic Acid on the Migration of Vascular Smooth Muscle Cells Is Partially Dependent on Notch Regulation of MMP-2/-9 Am J Pathol 2008 172: 1430-1440. First published online April 10, 2008; doi:10.2353/ajpath.2008.070951 [Abstract] [Full Text] [PDF] Supplemental Material

Correspondence: Elias Polykandriotis, Andreas Arkudas, Raymund E. Horch, Ulrich Kneser, and Geraldine Mitchell To Matrigel or Not to Matrigel Am J Pathol 2008 172: 1441-1442. First published online April 10, 2008; doi:10.2353/ajpath.2008.071215 [Abstract] [Full Text] [PDF]

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