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Time-lapse confocal movie showing movement of smooth muscle cells (red) and endothelial cells (green) in pillars in vitro. One confocal image was taken every 20 minutes for 20 hours. The movie shows movement in pillars without (control; left) or with (BB94; right) addition of matrix metalloproteinase (MMP) inhibitor BB94. MMP inhibition decreased movement of smooth muscle cells in pillars. The white lines at the end of the movie indicate how far smooth muscle cells migrate over 20 hours.
The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.
The Journal of Molecular Diagnostics, the official publication of the Association for Molecular Pathology (AMP), co-owned by the American Society for Investigative Pathology (ASIP), seeks to publish high quality original papers on scientific advances in the translation and validation of molecular discoveries in medicine into the clinical diagnostic setting, and the description and application of technological advances in the field of molecular diagnostic medicine.