Issue Highlights

Cigarette smoking along with alcohol abuse may compromise lung innate defense

Diet may help manage intestinal and liver inflammation, and thereby non-alcoholic steatohepatitis

Tonsillar crypts may be targeted to manage human papillomavirus–associated tonsil cancers

Targeting calpain-1 in photoreceptors may help mitigate early diabetic retinopathy

Decreasing anaplastic lymphoma kinase function may reduce tumor burden in high-grade serous carcinoma models

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Editor's Choice

Myeloid Cells Are Enriched in Tonsillar Crypts, Providing Insight into the Viral Tropism of Human Papillomavirus
Austin K. Mattox, Jessica Roelands, Talia M. Saal, Yang Cheng, Darawan Rinchai, Wouter Hendrickx, Geoffrey D. Young, Thomas J. Diefenbach, Alan E. Berger, William H. Westra, Justin A. Bishop, William C. Faquin, Francesco M. Marincola, Mikael J. Pittet, Davide Bedognetti, Sara I. Pai
DOI: https://doi.org/10.1016/j.ajpath.2021.06.012
Vol. 191, Issue 10
Published online: July 22, 2021

Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy
Aicha Saadane, Yunpeng Du, Wallace B. Thoreson, Masaru Miyagi, Emma M. Lessieur, Jianying Kiser, Xiangyi Wen, Bruce A. Berkowitz, Timothy S. Kern
DOI: https://doi.org/10.1016/j.ajpath.2021.06.006
Vol. 191, Issue 10
Published online: June 29, 2021

AJP in the News

New study sheds light on how an autoimmune disorder may underlie male infertility

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Current Issue

October 2021

Volume 191, Issue 10

October 2021 Volume 191, Issue 10

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On the Cover

Ethics of AI in Pathology: Current Paradigms and Emerging Issues
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Call for Papers

The American Journal of Pathology calls for manuscripts that address mechanisms of SARS-CoV-2 pathogenesis or provide a foundation for future mechanistic inquiries.

Audio/Video

Three-dimensional visualization of Epstein-Barr virus (EBV)-B95.8/firefly luciferase 2 (fLuc2) spread of infection and/or infected cells in long-term humanized mice. Mice were infected 15 weeks after CD34⁺ stem cell transplantation with 1 × 10⁵ green fluorescent protein Raji infectious units (GRUs), and IVIS imaging combined with a SpectrumCT was performed 5 weeks later. One representative mouse is shown, corresponding to the same animal depicted in Figure 1 E.

Read the Open Access article for free: Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1–Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice

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