Home Page: The American Journal of Pathology

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Articles in Press

Regular Article
Development of Scaffold-free 3D Cholangiocyte Organoids to Study the Progression of Primary Sclerosing Cholangitis
Published online: May 30, 2023
Regular Article
Innate Lymphoid Cells and Interferons Limit Neurologic and Articular Complications of Brucellosis
Published online: May 30, 2023
Regular Article
Transcription factor Foxo1 mediates TGF-β1-induced apoptosis in hepatocytes
Published online: May 30, 2023
Regular Article
Dysregulation of spliceosomes complex induces retinitis pigmentosa-like characteristics in sf3b4-depleted zebrafish
Published online: May 30, 2023

Editor's Choice

Short communication
Free
The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers
Nuber et al.
Published online: February 8, 2023
Regular article Vascular biology, atherosclerosis, and endothelium biology
Free
Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces Senescence in Vascular Smooth Muscle Cells
Corbett et al.
Published in issue: May 2023

Issue Highlights

Regular article Gastrointestinal, hepatobiliary, and pancreatic pathology
A Spatial Atlas of Wnt Receptors in Adult Mouse Liver
Gayden et al.
Published online: February 9, 2023
Regular article Machine learning, computational pathology, and biophysical imaging
Tensor Decomposition of Largest Convolutional Eigenvalues Reveals Pathologic Predictive Power of RhoB in Rectal Cancer Biopsy
Pham et al.
Published online: February 3, 2023
Regular article Tumorigenesis and neoplastic progression
Protein Kinase D2 and D3 Promote Prostate Cancer Cell Bone Metastasis by Positively Regulating Runx2 in a MEK/ERK1/2–Dependent Manner
Roy et al.
Published online: February 3, 2023
Regular article Vascular biology, atherosclerosis, and endothelium biology
Free
Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces Senescence in Vascular Smooth Muscle Cells
Corbett et al.
Published in issue: May 2023

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Time-lapse confocal movie showing movement of smooth muscle cells (red) and endothelial cells (green) in pillars in vitro. One confocal image was taken every 20 minutes for 20 hours. The movie shows movement in pillars without (control; left) or with (BB94; right) addition of matrix metalloproteinase (MMP) inhibitor BB94. MMP inhibition decreased movement of smooth muscle cells in pillars. The white lines at the end of the movie indicate how far smooth muscle cells migrate over 20 hours.

Read the Open Access article for free: Intussusceptive Angiogenesis in Human Metastatic Malignant Melanoma

Study in SARS-CoV2?infected mice may lay the groundwork for novel therapies to reduce the severity of COVID-19

Myofiber Typing of Muscle in β-Klotho (–/–) Ki26894– Mouse

About

Cover Image - The American Journal of Pathology, Volume 193, Issue 5

The American Journal of Pathology, official journal of the American Society for Investigative Pathology, published by Elsevier, Inc., seeks high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease. The editors will consider basic, translational, and clinical investigations that directly address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiries. Examples of such foundational investigations include data mining, identification of biomarkers, molecular pathology, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence are also welcome. High priority is given to studies of human disease and relevant experimental models using molecular, cellular, and organismal approaches.