Stromal AR in Prostate Development
Stromal-Epithelial Interactions in Fetal Prostate
Mediators of AR Expression in Prostate Development
Stromal Cells in Prostate Carcinogenesis
Morphological Modifications in Stroma
Factors Promoting the Stromal Modification
Wound Repair as an Analogy for Carcinogenesis of Stroma
Progressive Loss of AR Expression in Stromal Cell Transition from Benign to Cancer and during its Progression
Transition from Benign to Neoplasia
Progression from Castration-Sensitive to Castration-Resistant PCa
Understanding the Mechanisms of Loss of AR Expression
- DeGraff D.J.
- Grabowska M.M.
- Case T.C.
- Yu X.
- Herrick M.K.
- Hayward W.J.
- Strand D.W.
- Cates J.M.
- Hayward S.W.
- Gao N.
- Walter M.A.
- Buttyan R.
- Yi Y.
- Kaestner K.H.
- Matusik R.J.
Stromal AR Inhibits Cancer Epithelial Cell Growth, Causing a Functional Reversal
Need to Re-Evaluate the Role of Continued ADT in CRPC and Future Directions
- Hussain M.
- Tangen C.M.
- Berry D.L.
- Higano C.S.
- Crawford E.D.
- Liu G.
- Wilding G.
- Prescott S.
- Sundaram S.K.
- Small E.J.
- Dawson N.A.
- Donnelly B.J.
- Venner P.M.
- Vaishampayan U.N.
- Schellhammer P.F.
- Quinn D.I.
- Raghavan D.
- Ely B.
- Moinpour C.M.
- Vogelzang N.J.
- Thompson I.M.
- Cancer statistics, 2012.CA Cancer J Clin. 2012; 62: 10-29
- Stromal development in the ventral prostate, anterior prostate and seminal vesicle of the rat.Acta Anat (Basel). 1996; 155: 94-103
- Autoradiographic studies of androgen-binding sites in the rat urogenital sinus and postnatal prostate.J Endocrinol. 1985; 104: 87-92
- Androgen receptor in prostate cancer.Endocr Rev. 2004; 25: 276-308
- Stromal-epithelial interactions–I: induction of prostatic phenotype in urothelium of testicular feminized (Tfm/y) mice.J Steroid Biochem. 1981; 14: 1317-1324
- Epithelial-stromal interactions in development of the urogenital tract.Int Rev Cytol. 1976; 47: 137-194
- Androgen receptor expression in developing male reproductive organs.Endocrinology. 1991; 128: 2867-2873
- Immunohistochemical and in situ hybridization analysis of androgen receptor expression during the development of the mouse prostate gland.J Endocrinol. 1991; 129: 83-89
- The possible influences of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice.J Exp Zool. 1978; 205: 181-194
- Normal and abnormal development of the male urogenital tract: role of androgens, mesenchymal-epithelial interactions and growth factors.J Androl. 1992; 13: 465-475
- Suppressed prostate epithelial development with impaired branching morphogenesis in mice lacking stromal fibromuscular androgen receptor.Mol Endocrinol. 2012; 26: 52-66
- Analysis of prostatic bud induction by brief androgen treatment in the fetal rat urogenital sinus.J Endocrinol. 1986; 110: 467-470
- Autoradiographic localization of androgen binding in the developing mouse prostate.Prostate. 1983; 4: 367-373
- Expression of androgen receptor associated protein 55 (ARA55) in the developing human fetal prostate.J Urol. 2005; 173: 2190-2193
- Hormonal, cellular, and molecular control of prostatic development.Dev Biol. 2003; 253: 165-174
- The role of smooth muscle in regulating prostatic induction.Development. 2002; 129: 1905-1912
- Induction of prostatic morphology and secretion in urothelium by seminal vesicle mesenchyme.Development. 1995; 121: 2199-2207
- Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle.Acta Anat (Basel). 1996; 155: 81-93
- The endocrinology and developmental biology of the prostate.Endocr Rev. 1987; 8: 338-362
- Epithelial-mesenchymal interactions in prostatic development, I: morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder.J Cell Biol. 1983; 96: 1662-1670
- Heterospecific induction of prostatic development in tissue recombinants prepared with mouse, rat, rabbit and human tissues.Differentiation. 1983; 24: 174-180
- Role of epithelial-mesenchymal interactions in the differentiation and spatial organization of visceral smooth muscle.Epithelial Cell Biol. 1992; 1: 76-83
- Assessment of prostatic protein secretion in tissue recombinants made of urogenital sinus mesenchyme and urothelium from normal or androgen-insensitive mice.Endocrinology. 1993; 132: 2342-2350
- Paracrine regulation of epithelial progesterone receptor by estradiol in the mouse female reproductive tract.Biol Reprod. 2000; 62: 821-830
- The rat prostatic epithelial cell line NRP-152 can differentiate in vivo in response to its stromal environment.Prostate. 1999; 39: 205-212
- Malignant transformation in a nontumorigenic human prostatic epithelial cell line.Cancer Res. 2001; 61: 8135-8142
- The effect of androgen deprivation on branching morphogenesis in the mouse prostate.Dev Biol. 1988; 128: 1-14
- Stromal epithelial interactions in adult organs.Cell Differ Dev. 1985; 17: 137-148
- Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault.Endocr Relat Cancer. 2002; 9: 61-73
- Growth factors and epithelial-stromal interactions in prostate cancer development.Int Rev Cytol. 2000; 199: 65-116
- Role of mesenchymal-epithelial interactions in normal and abnormal development of the mammary gland and prostate.Cancer. 1994; 74: 1030-1044
- Regulation of prostatic growth and function by peptide growth factors.Prostate. 1996; 28: 392-405
- Influence of transforming growth factor beta 1 and other growth factors on basic fibroblast growth factor level and proliferation of cultured human prostate-derived fibroblasts.Prostate. 1993; 22: 183-197
- IL-1 induces IGF-dependent epithelial proliferation in prostate development and reactive hyperplasia.Sci Signal. 2009; 2: ra49
- Altered prostate epithelial development in mice lacking the androgen receptor in stromal fibroblasts.Prostate. 2012; 72: 437-449
- Altered prostate epithelial development and IGF-1 signal in mice lacking the androgen receptor in stromal smooth muscle cells.Prostate. 2011; 71: 517-524
- Tumors: wounds that do not heal: similarities between tumor stroma generation and wound healing.N Engl J Med. 1986; 315: 1650-1659
- Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.Cancer Res. 1999; 59: 5002-5011
- What might a stromal response mean to prostate cancer progression?.Cancer Metastasis Rev. 1998; 17: 411-419
- Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.Clin Cancer Res. 2002; 8: 2912-2923
- Epithelial-stromal interactions in colon cancer.Int J Dev Biol. 1993; 37: 203-211
- Embryonic inductive tissues that cause histologic differentiation of murine mammary carcinoma in vitro.J Natl Cancer Inst. 1975; 54: 913-922
- Influence of male genital tract mesenchymes on differentiation of Dunning prostatic adenocarcinoma.Cancer Res. 1990; 50: 4747-4754
- Mesenchyme-induced changes in the neoplastic characteristics of the Dunning prostatic adenocarcinoma.Cancer Res. 1991; 51: 4924-4930
- Intrauterine transplantation of rat basal cell carcinoma as a model for reconversion of malignant to benign growth.Cancer Res. 1977; 37: 2544-2552
- Effect of normal endometrial stroma on growth and differentiation in Ishikawa endometrial adenocarcinoma cells.Cancer Res. 2002; 62: 79-88
- The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium.Epithelial Cell Biol. 1993; 2: 79-89
- Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction.Physiol Rev. 1996; 76: 69-125
- Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer.Clin Cancer Res. 2003; 9: 4792-4801
- Reactive stroma in prostate cancer progression.J Urol. 2001; 166: 2472-2483
- Granulation tissue as a contractile organ: a study of structure and function.J Exp Med. 1972; 135: 719-734
- Contraction of granulation tissue in vitro: similarity to smooth muscle.Science. 1971; 173: 548-550
- Modulation of fibroblastic cytoskeletal features during wound healing and fibrosis.Pathol Res Pract. 1994; 190: 851-853
- TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.Science. 2004; 303: 848-851
- The stroma reaction myofibroblast: a key player in the control of tumor cell behavior.Int J Dev Biol. 2004; 48: 509-517
- Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.PLoS One. 2012; 7: e42516
- Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts.Prostate. 2009; 69: 991-1000
- Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin.Mol Cancer Ther. 2009; 8: 1378-1386
- Versican accumulation in human prostatic fibroblast cultures is enhanced by prostate cancer cell-derived transforming growth factor beta1.Cancer Res. 2001; 61: 926-930
- Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro.Mol Endocrinol. 1992; 6: 15-25
- Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model.Hum Reprod. 2001; 16: 836-845
- Precise microdissection of human prostate cancers reveals genotypic heterogeneity.Cancer Res. 1998; 58: 23-28
- Clonal mutations in the cancer-associated fibroblasts: the case against genetic coevolution.Cancer Res. 2009; 69 (discussion 6769): 6765-6768
- Origin of carcinoma associated fibroblasts.Cell Cycle. 2009; 8: 589-595
- Distinct epigenetic changes in the stromal cells of breast cancers.Nat Genet. 2005; 37: 899-905
- Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer.Cancer Res. 2006; 66: 29-33
- Global gene expression analysis of reactive stroma in prostate cancer.Clin Cancer Res. 2009; 15: 3979-3989
- Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium.Cancer Res. 2007; 67: 4244-4253
- Altered TGF-beta signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.Cancer Res. 2011; 71: 1272-1281
- A system for studying epithelial-stromal interactions reveals distinct inductive abilities of stromal cells from benign prostatic hyperplasia and prostate cancer.Endocrinology. 2005; 146: 13-18
- Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells.Cancer Res. 2001; 61: 5038-5044
- High level of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate: cancer patients treated with radical prostatectomy.Am J Surg Pathol. 2004; 28: 928-934
- Altered expression of androgen receptor in the malignant epithelium and adjacent stroma is associated with early relapse in prostate cancer.Cancer Res. 2001; 61: 423-427
- Malignant transformation of human prostatic epithelium is associated with the loss of androgen receptor immunoreactivity in the surrounding stroma.Clin Cancer Res. 1999; 5: 569-576
- Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients.Prostate. 2009; 69: 799-809
- Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complex.Cancer Res. 2008; 68: 2678-2688
- Decrease in stromal androgen receptor associates with androgen-independent disease and promotes prostate cancer cell proliferation and invasion.J Cell Mol Med. 2008; 12: 2790-2798
- Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation.Development. 2005; 132: 3431-3443
- Expression of Foxa transcription factors in the developing and adult murine prostate.Prostate. 2005; 62: 339-352
- FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype.Lab Invest. 2014; 94: 726-739
- Foxa1 and foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially.Ann N Y Acad Sci. 2005; 1061: 77-93
- Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching.Mol Cell Biol. 2012; 32: 2454-2466
- Tissue-specific consequences of cyclin D1 overexpression in prostate cancer progression.Cancer Res. 2007; 67: 8188-8197
- Smooth muscle-epithelial interactions in normal and neoplastic prostatic development.Acta Anat (Basel). 1996; 155: 63-72
- Normal development and carcinogenesis of the prostate: a unifying hypothesis.Ann N Y Acad Sci. 1996; 784: 50-62
- Stromal-epithelial interactions in the normal and neoplastic prostate.Br J Urol. 1997; 79: 18-26
- Racial differences in prostate androgen levels in men with clinically localized prostate cancer.J Urol. 2004; 171: 2277-2280
- Interaction between prostatic fibroblast and epithelial cells in culture: role of androgen.Endocrinology. 1989; 125: 2719-2727
- Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts.Cancer Res. 1991; 51: 3753-3761
- Prostate and bone fibroblasts induce human prostate cancer growth in vivo: implications for bidirectional tumor-stromal cell interaction in prostate carcinoma growth and metastasis.J Urol. 1992; 147: 1151-1159
- Role of epithelial-stromal interactions in the control of gene expression in the prostate: an hypothesis.Prostate. 1986; 9: 375-385
- Targeting the stromal androgen receptor in primary prostate tumors at earlier stages.Proc Natl Acad Sci U S A. 2008; 105: 12188-12193
- Androgen receptor in human prostate cancer-associated fibroblasts promotes prostate cancer epithelial cell growth and invasion.Med Oncol. 2013; 30: 674
- Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1.Dis Model Mech. 2013; 6: 530-536
- Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.Cancer Res. 1997; 57: 314-319
- Bilateral orchiectomy with or without flutamide for metastatic prostate cancer.N Engl J Med. 1998; 339: 1036-1042
- Intermittent versus continuous androgen deprivation in prostate cancer.N Engl J Med. 2013; 368: 1314-1325
- Phase 1 trial of high-dose exogenous testosterone in patients with castration-resistant metastatic prostate cancer.Eur Urol. 2009; 56: 237-244
- Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression.J Pathol. 2008; 216: 460-470
Supported by NIH grants 1U01CA149556-01A1 and 3U01CA149556-01S1 (P.L.), Department of Defense Prostate Cancer Research Program grants PC080010 and PC111624 (P.L.), and VA Merit grants 1I01BX001505-01 (P.L.) and 1U01 CA151924-01A1 (S.W.H.).
This material is based on work supported in part by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development (Biomedical Laboratory Research and Development).
Disclosures: None declared.
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