The role of transient receptor potential vanilloid 1 (TRPV1) ion channels in diabetic
gastroparesis (DGP) is unclear. Using high-fat diet–induced DGP mice, Xu and Liang
et al (Am J Pathol 2023, XX–XX) studied this role. TRPV1 activation facilitated gastric fundus relaxation by regulating
neuronal nitric oxide synthase and promoting nitric oxide release in normal mice.
However, these effects and associated mechanisms disappeared in high-fat diet–induced
DGP mice. TRPV1 dysfunction may contribute toward dysfunction of DGP gastric nitrergic
neuromuscular relaxation.
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Article info
Publication history
Accepted:
March 7,
2023
Received:
March 7,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Published by Elsevier Inc. on behalf of the American Society for Investigative Pathology.
