This Month in AJP|Articles in Press

This Month in AJP

        The role of transient receptor potential vanilloid 1 (TRPV1) ion channels in diabetic gastroparesis (DGP) is unclear. Using high-fat diet–induced DGP mice, Xu and Liang et al (Am J Pathol 2023, XX–XX) studied this role. TRPV1 activation facilitated gastric fundus relaxation by regulating neuronal nitric oxide synthase and promoting nitric oxide release in normal mice. However, these effects and associated mechanisms disappeared in high-fat diet–induced DGP mice. TRPV1 dysfunction may contribute toward dysfunction of DGP gastric nitrergic neuromuscular relaxation.
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