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The American Journal of Pathology
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  • Commentary
    Open Archive

    Hodgkin Lymphoma Cells Have a Specific Long Noncoding RNA Expression Pattern

    The American Journal of Pathology
    Vol. 186Issue 9p2251–2253Published online: July 22, 2016
    • Simone Anfossi
    • George A. Calin
    Cited in Scopus: 1
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      This commentary highlights the article by Tayari et al that suggests studying clinical implications of long noncoding RNAs as possible diagnostic and predictive biomarkers of Hodgkin lymphoma.
    • Commentary
      Open Archive

      Antisense Sense in Osteoclasts

      The American Journal of Pathology
      Vol. 186Issue 9p2248–2250Published online: July 21, 2016
      • Teun J. de Vries
      Cited in Scopus: 0
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        This commentary highlights the article by Li et al that proposes regulating Wilm's tumor-1 antisense RNA to control pathological bone resorption.
        Antisense Sense in Osteoclasts
      • Commentary
        Open Archive

        Regulatory T Cells in Idiopathic Pulmonary Fibrosis: Too Much of a Good Thing?

        The American Journal of Pathology
        Vol. 186Issue 8p1978–1981Published online: June 23, 2016
        • Meagan W. Moore
        • Erica L. Herzog
        Cited in Scopus: 12
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          This commentary highlights the article by Birjandi et al showing that alterations in regulatory T cells can exacerbate lung fibrosis.
        • Commentary
          Open Archive

          Huntington Disease: A Disease of DNA Methylation or DNA Breaks?

          The American Journal of Pathology
          Vol. 186Issue 7p1750–1753Published online: May 21, 2016
          • Mélanie L. Ferlazzo
          • Nicolas Foray
          Cited in Scopus: 9
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            This commentary highlights the article by Mollica et al that describes an interesting model for the clinical evolution of Huntington disease.
            Huntington Disease
          • Commentary
            Open Archive

            Mouse Osteoblasts Play a Crucial Role in the Immune System

            The American Journal of Pathology
            Vol. 186Issue 5p1078–1080Published online: March 16, 2016
            • Shigeru Kotake
            • Yuki Nanke
            Cited in Scopus: 1
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              This commentary highlights the article by Tu et al describing mechanisms in immune-mediated arthritis that may propel strategies to treat diseases involving the bone and immune system.
            • Commentary
              Open Archive

              Synthetic Prions Provide Clues for Understanding Prion Diseases

              The American Journal of Pathology
              Vol. 186Issue 4p761–764Published online: February 5, 2016
              • Thibaut Imberdis
              • David A. Harris
              Cited in Scopus: 5
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                This Commentary highlights the article by Makarava et al that discusses the formation of synthetic prions and the role of substrate levels in their evolution.
                Synthetic Prions Provide Clues for Understanding Prion Diseases
              • Commentary
                Open Archive

                Value of Autopsy Emphasized in the Case Report of a Single Patient with Middle East Respiratory Syndrome

                The American Journal of Pathology
                Vol. 186Issue 3p507–510Published online: December 24, 2015
                • David H. Walker
                Cited in Scopus: 15
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                  This commentary highlights the article by Ng et al, emphasizing the need for autopsies to better model infectious diseases such as Middle East respiratory syndrome.
                • Commentary

                  Insights into Environmental Factors Impacting Celiac Disease: Microbiota Modulation of Disease Pathogenesis

                  The American Journal of Pathology
                  Vol. 185Issue 11p2864–2866Published online: September 21, 2015
                  • Robin G. Lorenz
                  Cited in Scopus: 1
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                    This commentary highlights the article by Galipeau et al exploring the role of microbiota in modulating gluten immune response and celiac disease-like pathology in a humanized mouse model.
                  • Commentary
                    Open Archive

                    Stat5a/b in Prostate Cancer Metastasis

                    The American Journal of Pathology
                    Vol. 185Issue 9p2351–2353Published online: July 14, 2015
                    • Allen C. Gao
                    • Yezi Zhu
                    Cited in Scopus: 3
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                      This commentary highlights the article by Talati et al that describes novel mechanisms promoting metastasis in prostate cancer.
                    • Commentary
                      Open Archive

                      Genomic Catastrophe and Neoplastic Transformation

                      The American Journal of Pathology
                      Vol. 185Issue 7p1846–1849Published in issue: July, 2015
                      • William B. Coleman
                      Cited in Scopus: 1
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                        This commentary highlights the article by Zhou et al that describes an innovative experimental design that uncovered cell fusion in tumorigenesis.
                        Genomic Catastrophe and Neoplastic Transformation
                      • Commentary
                        Open Archive

                        A Road to Chronic Kidney Disease: Toward Glomerulosclerosis via Dendrin

                        The American Journal of Pathology
                        Vol. 185Issue 8p2072–2075Published online: June 8, 2015
                        • Francesca Becherucci
                        • Elena Lazzeri
                        • Paola Romagnani
                        Cited in Scopus: 3
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                          This commentary highlights the article by Weins et al that describes a potential mechanism to delay the onset and progression of end-stage kidney disease.
                          A Road to Chronic Kidney Disease
                        • Commentary
                          Open Archive

                          Insights into End-Organ Injury in HIV Infection: Dynamics of Monocyte Trafficking to the Brain in SIV Encephalitis

                          The American Journal of Pathology
                          Vol. 185Issue 6p1548–1551Published online: May 8, 2015
                          • Yuri Persidsky
                          Cited in Scopus: 1
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                            This commentary highlights the article by Nowlin et al, which explores the dynamic roles of macrophages in early and late central nervous system lentiviral disease.
                          • Commentary
                            Open Archive

                            Breaking the Barriers: New Role for Insulin-Like Growth Factor 1 Receptor in Vascular Permeability

                            The American Journal of Pathology
                            Vol. 185Issue 5p1198–1200Published online: March 6, 2015
                            • Sandhya Xavier
                            Cited in Scopus: 0
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                              This commentary highlights the article by Liang et al that describes a critical role for insulin-like growth factor 1 receptor in the progression of chronic kidney disease.
                            • Commentary
                              Open Access

                              Lessons Learned About Prostatic Transformation from the Age-Related Methylation of 5α-Reductase Type 2 Gene

                              The American Journal of Pathology
                              Vol. 185Issue 3p614–616Published online: February 17, 2015
                              • John T. Isaacs
                              Cited in Scopus: 3
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                                This commentary highlights the article by Ge et al, which proposes the use of methylation and expression of SRD5A2 as a gene signature to tailor therapies for prostatic diseases.
                              • Commentary
                                Open Access

                                ROCK and Rho: Promising Therapeutic Targets to Ameliorate Pulmonary Fibrosis

                                The American Journal of Pathology
                                Vol. 185Issue 4p909–912Published online: February 13, 2015
                                • David W.H. Riches
                                • Donald S. Backos
                                • Elizabeth F. Redente
                                Cited in Scopus: 15
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                                  This commentary highlights the article by Sisson et al, which establishes the importance of the myocardin-related transcription factor/serum response factor signaling pathway as a therapeutic target in the management of fibrotic lung disease.
                                  ROCK and Rho
                                • Commentary
                                  Open Access

                                  Why Do We Need a Nonhuman Primate Model of Smoking-Induced COPD?

                                  The American Journal of Pathology
                                  Vol. 185Issue 3p610–613Published online: January 7, 2015
                                  • Jeffrey L. Curtis
                                  • Christine M. Freeman
                                  Cited in Scopus: 3
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                                    This Commentary highlights the article by Polverino et al, describing the development of a novel nonhuman primate model of cigarette smoke–induced chronic obstructive pulmonary disease.
                                  • Commentary
                                    Open Archive

                                    Pulmonary Veno-Occlusive Disease: A Rare Cause of Pulmonary Hypertension

                                    The American Journal of Pathology
                                    Vol. 185Issue 2p302–304Published online: December 17, 2014
                                    • Kazuyuki Yahagi
                                    • Renu Virmani
                                    Cited in Scopus: 0
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                                      This commentary highlights the article by Ranchoux and Günther, showing a cause-and-effect link between alkylating agents and pulmonary veno-occlusive disease.
                                    • Commentary
                                      Open Archive

                                      The Role of SIRT1 in Cancer: The Saga Continues

                                      The American Journal of Pathology
                                      Vol. 185Issue 1p26–28Published online: November 17, 2014
                                      • Melissa J. Wilking
                                      • Nihal Ahmad
                                      Cited in Scopus: 30
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                                        This Commentary highlights the article by Di Sante et al, which presents data supporting the status of SIRT1 as a tumor suppressor in prostate cancer.
                                      • Commentary
                                        Open Archive

                                        Mitochondrial DNA Mutations and Cancer: Lessons from the Parathyroid

                                        The American Journal of Pathology
                                        Vol. 184Issue 11p2852–2854Published online: September 18, 2014
                                        • Konstantin Popadin
                                        • Konstantin V. Gunbin
                                        • Konstantin Khrapko
                                        Cited in Scopus: 2
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                                          This commentary highlights the article by Müller-Höcker et al, which provides a different view on the distribution and role of mtDNA mutations in oncocytic tumors.
                                        • Commentary
                                          Open Archive

                                          Syndecan 4 Signaling and Intervertebral Disc Degeneration

                                          The American Journal of Pathology
                                          Vol. 184Issue 9p2371–2373Published in issue: September, 2014
                                          • Fackson Mwale
                                          Cited in Scopus: 3
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                                            This commentary highlights the article by Wang et al, exploring the regulatory relationship between matrix metalloproteinase-3 and syndecan 4 in disc degeneration.
                                          • Commentary
                                            Open Archive

                                            Fusing Transcriptomics to Progressive Prostate Cancer

                                            The American Journal of Pathology
                                            Vol. 184Issue 10p2608–2610Published online: August 13, 2014
                                            • Masaya Jimbo
                                            • Karen E. Knudsen
                                            • Jonathan R. Brody
                                            Cited in Scopus: 0
                                            Cme article
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                                              This commentary highlights the article by Yu et al, describing a set of novel fusion transcripts strongly associated with prostate cancer prognosis.
                                              Fusing Transcriptomics to Progressive Prostate Cancer
                                            • Commentary

                                              Genetic Control of Nerve Conduction Velocity May Influence Multiple Sclerosis Phenotype

                                              The American Journal of Pathology
                                              Vol. 184Issue 9p2369–2370Published online: August 12, 2014
                                              • Hans Lassmann
                                              Cited in Scopus: 1
                                              Cme article
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                                                This commentary highlights the article by Lemcke et al that reports a polymorphism in the Inpp4b gene, which is associated with increased risk of developing multiple sclerosis.
                                              • Commentary
                                                Open Archive

                                                Exploiting Endogenous Anti-Inflammatory Pathways as a Therapeutic Approach to Multiorgan Inflammatory Disease

                                                The American Journal of Pathology
                                                Vol. 184Issue 8p2154–2155Published online: July 9, 2014
                                                • John L. Wallace
                                                Cited in Scopus: 1
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                                                  This Commentary highlights the article by Montero-Melendez et al, revealing novel protective properties of endogenous melanocortin receptor 3 on periodontal status in health and disease and suggesting a new genus of anti-arthritic bone-sparing therapeutics.
                                                • Commentary
                                                  Open Access

                                                  The Liver Is a Peculiar Organ When It Comes to Stem Cells

                                                  The American Journal of Pathology
                                                  Vol. 184Issue 5p1263–1267Published online: March 31, 2014
                                                  • George K. Michalopoulos
                                                  Cited in Scopus: 28
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                                                    This Commentary highlights the article by Sekiya and Suzuki, detailing genetic lineage tracing to determine the origin of cells that form primitive ductules in a mouse model of chronic liver injury.
                                                  • Commentary

                                                    The BRC Canopy: An Important Player in Bone Remodeling

                                                    The American Journal of Pathology
                                                    Vol. 184Issue 4p924–926Published online: February 24, 2014
                                                    • Katherine Wesseling-Perry
                                                    Cited in Scopus: 6
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                                                      This Commentary highlights the article by Andersen et al, which describes structural changes in bone associated with increased bone resorption in osteoporotic post-menopausal women.
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