Commentaries
Hodgkin Lymphoma Cells Have a Specific Long Noncoding RNA Expression Pattern
This commentary highlights the article by Tayari et al that suggests studying clinical implications of long noncoding RNAs as possible diagnostic and predictive biomarkers of Hodgkin lymphoma.Antisense Sense in Osteoclasts
This commentary highlights the article by Li et al that proposes regulating Wilm's tumor-1 antisense RNA to control pathological bone resorption.Regulatory T Cells in Idiopathic Pulmonary Fibrosis: Too Much of a Good Thing?
This commentary highlights the article by Birjandi et al showing that alterations in regulatory T cells can exacerbate lung fibrosis.Huntington Disease: A Disease of DNA Methylation or DNA Breaks?
This commentary highlights the article by Mollica et al that describes an interesting model for the clinical evolution of Huntington disease.Mouse Osteoblasts Play a Crucial Role in the Immune System
This commentary highlights the article by Tu et al describing mechanisms in immune-mediated arthritis that may propel strategies to treat diseases involving the bone and immune system.Synthetic Prions Provide Clues for Understanding Prion Diseases
This Commentary highlights the article by Makarava et al that discusses the formation of synthetic prions and the role of substrate levels in their evolution.Value of Autopsy Emphasized in the Case Report of a Single Patient with Middle East Respiratory Syndrome
This commentary highlights the article by Ng et al, emphasizing the need for autopsies to better model infectious diseases such as Middle East respiratory syndrome.Insights into Environmental Factors Impacting Celiac Disease: Microbiota Modulation of Disease Pathogenesis
This commentary highlights the article by Galipeau et al exploring the role of microbiota in modulating gluten immune response and celiac disease-like pathology in a humanized mouse model.Stat5a/b in Prostate Cancer Metastasis
This commentary highlights the article by Talati et al that describes novel mechanisms promoting metastasis in prostate cancer.Genomic Catastrophe and Neoplastic Transformation
This commentary highlights the article by Zhou et al that describes an innovative experimental design that uncovered cell fusion in tumorigenesis.A Road to Chronic Kidney Disease: Toward Glomerulosclerosis via Dendrin
This commentary highlights the article by Weins et al that describes a potential mechanism to delay the onset and progression of end-stage kidney disease.Insights into End-Organ Injury in HIV Infection: Dynamics of Monocyte Trafficking to the Brain in SIV Encephalitis
This commentary highlights the article by Nowlin et al, which explores the dynamic roles of macrophages in early and late central nervous system lentiviral disease.Breaking the Barriers: New Role for Insulin-Like Growth Factor 1 Receptor in Vascular Permeability
This commentary highlights the article by Liang et al that describes a critical role for insulin-like growth factor 1 receptor in the progression of chronic kidney disease.Lessons Learned About Prostatic Transformation from the Age-Related Methylation of 5α-Reductase Type 2 Gene
This commentary highlights the article by Ge et al, which proposes the use of methylation and expression of SRD5A2 as a gene signature to tailor therapies for prostatic diseases.ROCK and Rho: Promising Therapeutic Targets to Ameliorate Pulmonary Fibrosis
This commentary highlights the article by Sisson et al, which establishes the importance of the myocardin-related transcription factor/serum response factor signaling pathway as a therapeutic target in the management of fibrotic lung disease.Why Do We Need a Nonhuman Primate Model of Smoking-Induced COPD?
This Commentary highlights the article by Polverino et al, describing the development of a novel nonhuman primate model of cigarette smoke–induced chronic obstructive pulmonary disease.Pulmonary Veno-Occlusive Disease: A Rare Cause of Pulmonary Hypertension
This commentary highlights the article by Ranchoux and Günther, showing a cause-and-effect link between alkylating agents and pulmonary veno-occlusive disease.The Role of SIRT1 in Cancer: The Saga Continues
This Commentary highlights the article by Di Sante et al, which presents data supporting the status of SIRT1 as a tumor suppressor in prostate cancer.Mitochondrial DNA Mutations and Cancer: Lessons from the Parathyroid
This commentary highlights the article by Müller-Höcker et al, which provides a different view on the distribution and role of mtDNA mutations in oncocytic tumors.Syndecan 4 Signaling and Intervertebral Disc Degeneration
This commentary highlights the article by Wang et al, exploring the regulatory relationship between matrix metalloproteinase-3 and syndecan 4 in disc degeneration.Fusing Transcriptomics to Progressive Prostate Cancer
This commentary highlights the article by Yu et al, describing a set of novel fusion transcripts strongly associated with prostate cancer prognosis.Genetic Control of Nerve Conduction Velocity May Influence Multiple Sclerosis Phenotype
This commentary highlights the article by Lemcke et al that reports a polymorphism in the Inpp4b gene, which is associated with increased risk of developing multiple sclerosis.Exploiting Endogenous Anti-Inflammatory Pathways as a Therapeutic Approach to Multiorgan Inflammatory Disease
This Commentary highlights the article by Montero-Melendez et al, revealing novel protective properties of endogenous melanocortin receptor 3 on periodontal status in health and disease and suggesting a new genus of anti-arthritic bone-sparing therapeutics.The Liver Is a Peculiar Organ When It Comes to Stem Cells
This Commentary highlights the article by Sekiya and Suzuki, detailing genetic lineage tracing to determine the origin of cells that form primitive ductules in a mouse model of chronic liver injury.The BRC Canopy: An Important Player in Bone Remodeling
This Commentary highlights the article by Andersen et al, which describes structural changes in bone associated with increased bone resorption in osteoporotic post-menopausal women.
