Commentaries
Insights into Environmental Factors Impacting Celiac Disease: Microbiota Modulation of Disease Pathogenesis
This commentary highlights the article by Galipeau et al exploring the role of microbiota in modulating gluten immune response and celiac disease-like pathology in a humanized mouse model.Stat5a/b in Prostate Cancer Metastasis
This commentary highlights the article by Talati et al that describes novel mechanisms promoting metastasis in prostate cancer.Genomic Catastrophe and Neoplastic Transformation
This commentary highlights the article by Zhou et al that describes an innovative experimental design that uncovered cell fusion in tumorigenesis.A Road to Chronic Kidney Disease: Toward Glomerulosclerosis via Dendrin
This commentary highlights the article by Weins et al that describes a potential mechanism to delay the onset and progression of end-stage kidney disease.Insights into End-Organ Injury in HIV Infection: Dynamics of Monocyte Trafficking to the Brain in SIV Encephalitis
This commentary highlights the article by Nowlin et al, which explores the dynamic roles of macrophages in early and late central nervous system lentiviral disease.Breaking the Barriers: New Role for Insulin-Like Growth Factor 1 Receptor in Vascular Permeability
This commentary highlights the article by Liang et al that describes a critical role for insulin-like growth factor 1 receptor in the progression of chronic kidney disease.Lessons Learned About Prostatic Transformation from the Age-Related Methylation of 5α-Reductase Type 2 Gene
This commentary highlights the article by Ge et al, which proposes the use of methylation and expression of SRD5A2 as a gene signature to tailor therapies for prostatic diseases.ROCK and Rho: Promising Therapeutic Targets to Ameliorate Pulmonary Fibrosis
This commentary highlights the article by Sisson et al, which establishes the importance of the myocardin-related transcription factor/serum response factor signaling pathway as a therapeutic target in the management of fibrotic lung disease.Why Do We Need a Nonhuman Primate Model of Smoking-Induced COPD?
This Commentary highlights the article by Polverino et al, describing the development of a novel nonhuman primate model of cigarette smoke–induced chronic obstructive pulmonary disease.Pulmonary Veno-Occlusive Disease: A Rare Cause of Pulmonary Hypertension
This commentary highlights the article by Ranchoux and Günther, showing a cause-and-effect link between alkylating agents and pulmonary veno-occlusive disease.The Role of SIRT1 in Cancer: The Saga Continues
This Commentary highlights the article by Di Sante et al, which presents data supporting the status of SIRT1 as a tumor suppressor in prostate cancer.Mitochondrial DNA Mutations and Cancer: Lessons from the Parathyroid
This commentary highlights the article by Müller-Höcker et al, which provides a different view on the distribution and role of mtDNA mutations in oncocytic tumors.Syndecan 4 Signaling and Intervertebral Disc Degeneration
This commentary highlights the article by Wang et al, exploring the regulatory relationship between matrix metalloproteinase-3 and syndecan 4 in disc degeneration.Fusing Transcriptomics to Progressive Prostate Cancer
This commentary highlights the article by Yu et al, describing a set of novel fusion transcripts strongly associated with prostate cancer prognosis.Genetic Control of Nerve Conduction Velocity May Influence Multiple Sclerosis Phenotype
This commentary highlights the article by Lemcke et al that reports a polymorphism in the Inpp4b gene, which is associated with increased risk of developing multiple sclerosis.Exploiting Endogenous Anti-Inflammatory Pathways as a Therapeutic Approach to Multiorgan Inflammatory Disease
This Commentary highlights the article by Montero-Melendez et al, revealing novel protective properties of endogenous melanocortin receptor 3 on periodontal status in health and disease and suggesting a new genus of anti-arthritic bone-sparing therapeutics.The Liver Is a Peculiar Organ When It Comes to Stem Cells
This Commentary highlights the article by Sekiya and Suzuki, detailing genetic lineage tracing to determine the origin of cells that form primitive ductules in a mouse model of chronic liver injury.The BRC Canopy: An Important Player in Bone Remodeling
This Commentary highlights the article by Andersen et al, which describes structural changes in bone associated with increased bone resorption in osteoporotic post-menopausal women.Are Selective Estrogen Receptor Modulators (SERMs) a Therapeutic Option for HPV-Associated Cervical Lesions and Cancers?
This Commentary highlights the article by Spurgeon et al which evaluates oral SERM raloxifene as a potential therapeutic agent for HPV-associated cancer.Silence Please!: siRNA Approaches to Tighten the Intestinal Barrier
This Commentary highlights the article by Al-Sadi et al which reports on the molecular mechanisms and intracellular pathways involved in increased intestinal tight junction permeability mediated by TNF-α.Asbestos-Induced Mesothelioma: Is Fiber Biopersistence Really a Critical Factor?
This Commentary highlights the research by Qi et al detailing the similarities and differences between crocidolite and chrysotile asbestos in terms of their transcriptional effects and transforming actions in human mesothelial cells.Cannabinoid Receptor 2 Activation: A Means to Prevent Monocyte–Endothelium Engagement
This Commentary highlights the article by Rom et al which shows that selective cannabinoid receptor 2 activation in leukocytes decreases key steps in monocyte-blood brain barrier engagement suppressing inflammatory leukocyte responses and preventing neuroinflammation.Why Does Pandemic Influenza Virus Kill?
This Commentary highlights the article by Gao et al, which showed protracted viral replication and correlated viral load with illness duration and proinflammatory cytokine levels in lung tissue samples from 2009 H1N1 victims.Fungal Disease Following Contaminated Steroid Injections: Is Ready for Its Close-Up
This Commentary highlights the article by Ritter et al. that reported the pathology associated with the recent fungal outbreak associated with contaminated methylprednisolone acetate injections.New Hope for Prevention of Preterm Delivery
This Commentary highlights the article by Sundaram et al that described a novel use of a common organic solvent, N,N-dimethylacetamide (DMA) in preventing inflammation-mediated preterm birth.
