Although concerns about rigor and reproducibility in preclinical research are not new, a highly cited 2005 article by Ioannidis1, entitled “Why Most Published Research Findings Are False,” attracted attention by the New York Times (https://www.nytimes.com/2014/01/21/science/new-truths-that-only-one-can-see.html?, last accessed March 16, 2021), was condemned by some (https://replicationindex.com/2020/12/24/ioannidis-is-wrong-most-of-the-time, last accessed March 16, 2021), and has been followed by both special collections of journal articles, such as Nature's “Challenges in Irreproducible Research” collection (https://www.nature.com/collections/prbfkwmwvz, last accessed March 16, 2021), and by increased attention from funding agencies.