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The American Journal of Pathology
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  • Commentary
    Open Archive

    Lung Injury and Repair in Coronavirus Disease 2019–Related Acute Lung Injury

    The American Journal of Pathology
    Vol. 192Issue 3p406–409Published online: January 10, 2022
    • Thomas R. Martin
    Cited in Scopus: 1
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      The alveolar epithelium is the largest surface area of the body in continuous contact with the outside environment and is critical for effective gas exchange to support metabolism. The alveolar walls consist of three distinct layers: the alveolar epithelium, comprising type I and type II alveolar epithelial cells; a matrix scaffold; and the microvascular endothelium. Most of the alveolar surface is covered by thin type I epithelial cells that cover the matrix framework and are closely opposed to microvascular endothelial cells.
    • Commentary
      Open Archive

      METTL3-Mediated m6A Modification Links Liver Homeostasis and Pathology

      The American Journal of Pathology
      Vol. 192Issue 1p18–20Published online: November 10, 2021
      • Wenbo Ma
      • Tong Wu
      Cited in Scopus: 2
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        RNA modification is a new paradigm of epigenetic regulation of gene expression. This evolving field has been coined as RNA epigenetics or epitranscriptomics. Extensive studies over recent years have shown that RNA modifications affect multiple steps of RNA metabolism, including RNA export, splicing, processing, stability, degradation, and translation. Among different forms of RNA modifications, N6-methyladenosine (m6A) modification is the most prevalent form of messenger RNA modification in eukaryotes, which is critically implicated in the regulation of cellular functions.
      • Commentary
        Open Archive

        Pathophysiology of Hyaluronan Accumulation/Depolymerization in Osteoarthritic Joints

        The American Journal of Pathology
        Vol. 191Issue 11p1963–1965Published online: September 7, 2021
        • Yoshihiro Nishida
        Cited in Scopus: 2
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          In healthy articular cartilage, the extracellular matrix (ECM) is properly maintained by the overall anabolic and catabolic balance of slow synthesis and degradation, a so-called homeostatic state, under the influence of synovial metabolism. Though the ECM of articular cartilage tissue contains low amounts of hyaluronan (HA), its main components are collagen, type II, IX, and XI, and proteoglycans, such as aggrecan. Nevertheless, HA plays crucial roles in cartilage, especially in retaining aggrecan in tissues.
        • Commentary
          Open Archive

          Rigor, Reproducibility, and the P Value

          The American Journal of Pathology
          Vol. 191Issue 5p805–808Published online: March 6, 2021
          • Timothy J. O'Leary
          Cited in Scopus: 0
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            Although concerns about rigor and reproducibility in preclinical research are not new, a highly cited 2005 article by Ioannidis1, entitled “Why Most Published Research Findings Are False,” attracted attention by the New York Times (https://www.nytimes.com/2014/01/21/science/new-truths-that-only-one-can-see.html?, last accessed March 16, 2021), was condemned by some (https://replicationindex.com/2020/12/24/ioannidis-is-wrong-most-of-the-time, last accessed March 16, 2021), and has been followed by both special collections of journal articles, such as Nature's “Challenges in Irreproducible Research” collection (https://www.nature.com/collections/prbfkwmwvz, last accessed March 16, 2021), and by increased attention from funding agencies.
          • Commentary
            Open Archive

            Beyond Stiffness: Collagen Signaling in Pancreatic Cancer and Pancreas Regeneration

            The American Journal of Pathology
            Vol. 190Issue 8p1622–1624Published online: May 21, 2020
            • Huocong Huang
            • Rolf A. Brekken
            Cited in Scopus: 1
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              This commentary highlights the article by Ruggeri et al that reports the importance of discoidin domain receptor 1 in tissue homeostasis in pancreatic injury and pancreatic ductal adenocarcinoma pathogenesis.
            • Commentary
              Open Archive

              Podocytes: The Role of Lysosomes in the Development of Nephrotic Syndrome

              The American Journal of Pathology
              Vol. 190Issue 6p1172–1174Published online: April 16, 2020
              • Marica Giliberti
              • Adele Mitrotti
              • Loreto Gesualdo
              Cited in Scopus: 1
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                This commentary highlights the article by Li et al that links ceramide accumulation in podocytes to cellular damage and nephrotic syndrome.
              • Commentary
                Open Archive

                Lacrimal Gland Postganglionic Innervation: Unveiling the Role of Parasympathetic and Sympathetic Nerves in Stimulating Tear Secretion

                The American Journal of Pathology
                Vol. 190Issue 5p968–969Published online: March 31, 2020
                • Karina Dias-Teixeira
                Cited in Scopus: 2
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                  This commentary highlights the article by Jin et al that studied the regulation of lacrimal gland innervation by sympathetic and parasympathetic components.
                • Commentary
                  Open Archive

                  Bioactive Lipids in Shoulder Tendon Tears

                  The American Journal of Pathology
                  Vol. 189Issue 11p2149–2153Published online: September 14, 2019
                  • Undurti N. Das
                  Cited in Scopus: 1
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                    This commentary highlights the article by Dakin et al that demonstrates critical roles of bioactive lipids in the resolution of inflammation in shoulder tendon tears.
                  • Commentary
                    Open Archive

                    The Serotype-Specific Role of Regulator of Cov Polymorphisms in the Pathogenesis of Invasive Group A Streptococcal Infections

                    The American Journal of Pathology
                    Vol. 189Issue 10p1913–1915Published online: August 14, 2019
                    • Stephan Brouwer
                    • Mark J. Walker
                    Cited in Scopus: 1
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                      This commentary highlights the article by Bernard et al that reports the role of rocA polymorphisms in the pathogenesis of Group A Streptococcus.
                    • Commentary
                      Open Archive

                      Invasive Ductular Reaction: Form and Function

                      The American Journal of Pathology
                      Vol. 189Issue 8p1501–1504Published online: June 13, 2019
                      • David B. Wilson
                      • David A. Rudnick
                      Cited in Scopus: 5
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                        This commentary highlights the article by Clerbaux et al that describes the critical role of invasive ductular reaction in hepatocellular injury.
                        Invasive Ductular Reaction
                      • Commentary
                        Open Archive

                        Uterine Epithelial Development and Enhancer of Zeste Homolog 2: It Is Important for More than Just Cancer

                        The American Journal of Pathology
                        Vol. 189Issue 6p1176–1177Published online: April 13, 2019
                        • Xiyin Wang
                        • Shannon M. Hawkins
                        Cited in Scopus: 0
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                          This commentary highlights the article by Fang et al that describes the role of enhancer of zeste homolog 2 in endometrial development.
                        • Commentary
                          Open Archive

                          Centrosomal Proteins in Urothelial Tumors: New Pathways in Disease Pathogenesis

                          The American Journal of Pathology
                          Vol. 189Issue 6p1178–1179Published online: April 13, 2019
                          • Zoran Culig
                          Cited in Scopus: 0
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                            This commentary highlights the article by Li et al that identified the centrosomal protein 72 as a biomarker for prognosis of urothelial cancer.
                          • Commentary
                            Open Archive

                            A Link between the Gut and Bone: Bone Health Impacted by Changes in Gut Microbiota

                            The American Journal of Pathology
                            Vol. 189Issue 2p229–230Published in issue: February, 2019
                            • Larry J. Suva
                            Cited in Scopus: 2
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                              This commentary highlights the article by Hathaway-Schrader et al that studies the impact of antibiotic-disruption of the gut microbiota on long-term bone development.
                            • Commentary
                              Open Archive

                              Podocytes: Way to Go

                              The American Journal of Pathology
                              Vol. 189Issue 2p226–228Published online: December 10, 2018
                              • Mehmet M. Altintas
                              • Jochen Reiser
                              Cited in Scopus: 3
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                                This commentary highlights the article by Hara et al that discusses the clinical implications of mitotic catastrophe in podocyte health during diabetic kidney disease.
                                Podocytes
                              • Commentary
                                Open Archive

                                Autophagy-Based Diagnosis of Pregnancy Hypertension and Pre-Eclampsia

                                The American Journal of Pathology
                                Vol. 188Issue 11p2457–2460Published online: September 19, 2018
                                • Surendra Sharma
                                Cited in Scopus: 10
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                                  This commentary highlights the article by Aoki et al that shows that Atg7 deficiency–mediated placental autophagy imbalance may contribute towards pre-eclampsia.
                                  Autophagy-Based Diagnosis of Pregnancy Hypertension and Pre-Eclampsia
                                • Commentary
                                  Open Archive

                                  Atypical Protein Kinase C: Breaking Down Barriers in Ocular Disease?

                                  The American Journal of Pathology
                                  Vol. 188Issue 10p2142–2146Published online: September 13, 2018
                                  • Elizabeth A. Pearsall
                                  • Kip M. Connor
                                  Cited in Scopus: 0
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                                    This commentary highlights the article by Lin et al that demonstrates the therapeutic potential of small-molecule atypical protein kinase C inhibitors in inflammatory ocular disease.
                                    Atypical Protein Kinase C
                                  • Commentary
                                    Open Archive

                                    APOL1–miR-193 Axis as a Bifunctional Regulator of the Glomerular Parietal Epithelium: Maintaining Parietal Cell Phenotype versus Promoting Podocyte Differentiation

                                    The American Journal of Pathology
                                    Vol. 188Issue 11p2461–2463Published online: September 7, 2018
                                    • Joseph Jessee
                                    • Jeffrey B. Kopp
                                    Cited in Scopus: 3
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                                      This commentary highlights the article by Kumar et al that reports an essential role of APOL1 in maintaining podocyte phenotype.
                                    • Commentary
                                      Open Archive

                                      Therapeutic Role of Sphingosine-1–Phosphate Receptor 2 in the Progression of Esophageal Adenocarcinoma

                                      The American Journal of Pathology
                                      Vol. 188Issue 9p1949–1952Published online: July 16, 2018
                                      • Lindsey Kennedy
                                      • Gianfranco Alpini
                                      Cited in Scopus: 1
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                                        This commentary highlights the article by Liu et al that provides novel mechanistic insights in how conjugated bile acids promote invasive growth of esophageal adenocarcinoma.
                                        Therapeutic Role of Sphingosine-1–Phosphate Receptor 2 in the Progression of Esophageal Adenocarcinoma
                                      • Commentary
                                        Open Archive

                                        Murine Double Minute-2 Links Cell Cycle Control and Inflammation in Homeostasis and Disease

                                        The American Journal of Pathology
                                        Vol. 188Issue 9p1953–1955Published online: July 2, 2018
                                        • Martrez Ebrahim
                                        • Hans-Joachim Anders
                                        Cited in Scopus: 1
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                                          This commentary highlights the article by Fan et al that provides mechanistic insights into murine double minute-2's anti-inflammatory role in intraocular inflammation.
                                          Murine Double Minute-2 Links Cell Cycle Control and Inflammation in Homeostasis and Disease
                                        • Commentary
                                          Open Archive

                                          Linking Sex Differences in Non-Alcoholic Fatty Liver Disease to Bile Acid Signaling, Gut Microbiota, and High Fat Diet

                                          The American Journal of Pathology
                                          Vol. 187Issue 8p1658–1659Published in issue: August, 2017
                                          • John Y.L. Chiang
                                          Cited in Scopus: 4
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                                            This commentary highlights the article by Jena et al that studied the complex interplay between diet, bile acids, sex, and dysbiosis in hepatic steatosis and inflammation.
                                          • Commentary
                                            Open Archive

                                            Influenza Casts a Lung Shadow

                                            The American Journal of Pathology
                                            Vol. 187Issue 4p697–699Published online: February 18, 2017
                                            • Xavier De Luna
                                            • Kevan L. Hartshorn
                                            Cited in Scopus: 1
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                                              This commentary highlights the article by Pociask et al that provides new insights into the lingering effects of influenza infection.
                                            • Commentary
                                              Open Archive

                                              Is Centrosomal Protein 70, a Centrosomal Protein with New Roles in Breast Cancer Dissemination and Metastasis, a Facilitator of Epithelial-Mesenchymal Transition?

                                              The American Journal of Pathology
                                              Vol. 187Issue 3p494–497Published online: January 18, 2017
                                              • Pedro A. Lazo
                                              Cited in Scopus: 3
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                                                This commentary highlights the article by Shi et al that identified centrosomal protein 70 as a key mediator of breast cancer growth and metastasis.
                                                Is Centrosomal Protein 70, a Centrosomal Protein with New Roles in Breast Cancer Dissemination and Metastasis, a Facilitator of Epithelial-Mesenchymal Transition?
                                              • Commentary
                                                Open Archive

                                                miRNA-Coordinated Networks as Promising Therapeutic Targets for Acute Kidney Injury

                                                The American Journal of Pathology
                                                Vol. 187Issue 1p20–24Published online: November 17, 2016
                                                • Anton Jan van Zonneveld
                                                • Ton J. Rabelink
                                                • Roel Bijkerk
                                                Cited in Scopus: 9
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                                                  This commentary highlights the article by Wilflingseder et al that investigates the relationship between in vivo inhibition of miR-182 by antisense oligonucleotides and improved post-injury kidney function.
                                                  miRNA-Coordinated Networks as Promising Therapeutic Targets for Acute Kidney Injury
                                                • Commentary
                                                  Open Archive

                                                  Histone Deacetylase Inhibitory Approaches for the Management of Osteoarthritis

                                                  The American Journal of Pathology
                                                  Vol. 186Issue 10p2555–2558Published online: August 30, 2016
                                                  • Chandra K. Singh
                                                  • Minakshi Nihal
                                                  • Nihal Ahmad
                                                  Cited in Scopus: 3
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                                                    This commentary highlights the article by Makki and Haqqi that proposes the use of vorinostat as a therapeutic agent for the management of osteoarthritis.
                                                  • Commentary
                                                    Open Archive

                                                    BRAF Mutations Open Doors for N-Ethyl-N-Nitrosourea–Induced Gliomagenesis

                                                    The American Journal of Pathology
                                                    Vol. 186Issue 10p2551–2554Published online: August 18, 2016
                                                    • Robert S. McNeill
                                                    • David M. Irvin
                                                    • C. Ryan Miller
                                                    Cited in Scopus: 2
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                                                      This commentary highlights the article by Wang et al that describes a preclinical model for targeting BRAF-mutant gliomas.
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