July 2010

Richard (Dick) Gregory Lynch, M.D., 1934–2009

• Mark E. Sobel

Epigenetic Regulation of Myofibroblast Differentiation by DNA Methylation

• Biao Hu,
• Mehrnaz Gharaee-Kermani,
• Zhe Wu,
• Sem H. Phan

miR-182 as a Prognostic Marker for Glioma Progression and Patient Survival

• Lili Jiang,
• Pu Mao,
• Libing Song,
• ...
• Lianghu Qu,
• Shi-Yuan Cheng,
• Jun Li

Novel Molecular Imaging Approach for Subclinical Detection of Iritis and Evaluation of Therapeutic Success

• Fang Xie,
• Dawei Sun,
• Alexander Schering,
• ...
• Souska Zandi,
• Ping Liu,
• Ali Hafezi-Moghadam

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner

• Kartik Balachandran,
• Philippe Sucosky,
• Hanjoong Jo,
• Ajit P. Yoganathan

PDGF-C Mediates Glomerular Capillary Repair

• Peter Boor,
• Claudia R.C. van Roeyen,
• Uta Kunter,
• ...
• Frank Eitner,
• Jürgen Floege,
• Tammo Ostendorf

Early Growth Response-1 Induces and Enhances Vascular Endothelial Growth Factor-A Expression in Lung Cancer Cells

• Hiroaki Shimoyamada,
• Takuya Yazawa,
• Hanako Sato,
• ...
• Munetaka Masuda,
• Hisashi Oshiro,
• Hitoshi Kitamura

Deletion of Von Hippel-Lindau in Glomerular Podocytes Results in Glomerular Basement Membrane Thickening, Ectopic Subepithelial Deposition of Collagen α1α2α1(IV), Expression of Neuroglobin, and Proteinuria

• Brooke M. Steenhard,
• Kathryn Isom,
• Larysa Stroganova,
• ...
• Paul B. Freeburg,
• Lawrence B. Holzman,
• Dale R. Abrahamson

Cardiac-Specific Overexpression of HIF-1α Prevents Deterioration of Glycolytic Pathway and Cardiac Remodeling in Streptozotocin-Induced Diabetic Mice

• Wanli Xue,
• Lu Cai,
• Yi Tan,
• ...
• Y. James Kang,
• Xiaokun Li,
• Wenke Feng

Self-Improvement of Keratinocyte Differentiation Defects During Skin Maturation in ABCA12-Deficient Harlequin Ichthyosis Model Mice

• Teruki Yanagi,
• Masashi Akiyama,
• Hiroshi Nishihara,
• ...
• Takashi Kitahara,
• Shinya Tanaka,
• Hiroshi Shimizu

An Akt- and Fra-1-Dependent Pathway Mediates Platelet-Derived Growth Factor-Induced Expression of Thrombomodulin, a Novel Regulator of Smooth Muscle Cell Migration

• Aruna Ramachandran,
• Sandeep A. Ranpura,
• Edward M. Gong,
• Michelle Mulone,
• Glenn M. Cannon Jr.,
• Rosalyn M. Adam

N-Acetylcysteine Suppresses Retinal Detachment in an Experimental Model of Proliferative Vitreoretinopathy

• Hetian Lei,
• Gisela Velez,
• Jing Cui,
• ...
• David Maberley,
• Joanne Matsubara,
• Andrius Kazlauskas

Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β1/Snail Activation Aggravates Invasive Growth of Cholangiocarcinoma

• Yasunori Sato,
• Kenichi Harada,
• Keita Itatsu,
• ...
• Norihide Yoneda,
• Motoko Sasaki,
• Yasuni Nakanuma

A Human-Type Nonalcoholic Steatohepatitis Model with Advanced Fibrosis in Rabbits

• Tomohiro Ogawa,
• Hideki Fujii,
• Katsutoshi Yoshizato,
• Norifumi Kawada

2009 Pandemic Influenza A (H1N1)

Pathology and Pathogenesis of 100 Fatal Cases in the United States

• Wun-Ju Shieh,
• Dianna M. Blau,
• Amy M. Denison,
• ...
• Christopher Paddock,
• Timothy M. Uyeki,
• Sherif R. Zaki

CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway

• Jesmond Dalli,
• Guglielmo Rosignoli,
• Richard P.G. Hayhoe,
• Aleksander Edelman,
• Mauro Perretti

Targeting the Cannabinoid Pathway Limits the Development of Fibrosis and Autoimmunity in a Mouse Model of Systemic Sclerosis

• Amélie Servettaz,
• Niloufar Kavian,
• Carole Nicco,
• ...
• Sophie Lotersztajn,
• Bernard Weill,
• Frédéric Batteux

Myometrial Wound Healing Post-Cesarean Delivery in the MRL/MpJ Mouse Model of Uterine Scarring

• Catalin S. Buhimschi,
• Guomao Zhao,
• Nicoleta Sora,
• Joseph A. Madri,
• Irina A. Buhimschi

Epithelial to Mesenchymal Transition in Gingival Overgrowth

• Siddika Selva Sume,
• Alpdogan Kantarci,
• Alan Lee,
• Hatice Hasturk,
• Philip C. Trackman

N-Acetylcysteine and 15 Deoxy-^Δ12,14-Prostaglandin J2 Exert a Protective Effect Against Autoimmune Thyroid Destruction in Vivo but Not Against Interleukin-1α/Interferon γ-Induced Inhibitory Effects in Thyrocytes in Vitro

• Sylvie Poncin,
• Ides M. Colin,
• Brigitte Decallonne,
• ...
• Marie-Christine Many,
• Jean-François Denef,
• Anne-Catherine Gérard

Tissue Slice Grafts

An in Vivo Model of Human Prostate Androgen Signaling

• Hongjuan Zhao,
• Rosalie Nolley,
• Zuxiong Chen,
• Donna M. Peehl

A Novel Single-Chain Antibody Fragment for Detection of Mannose 6-Phosphate-Containing Proteins

Application in Mucolipidosis Type II Patients and Mice

• Sven Müller-Loennies,
• Giovanna Galliciotti,
• Katrin Kollmann,
• Markus Glatzel,
• Thomas Braulke

Matrix Metalloproteinase Inhibitor Batimastat Alleviates Pathology and Improves Skeletal Muscle Function in Dystrophin-Deficient mdx Mice

• Akhilesh Kumar,
• Shephali Bhatnagar,
• Ashok Kumar

Differential Effects of Myopathy-Associated Caveolin-3 Mutants on Growth Factor Signaling

• Eva Brauers,
• Agnes Dreier,
• Andreas Roos,
• Berthold Wormland,
• Joachim Weis,
• Alexander Krüttgen

CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis

• Zinayida Shevtsova,
• Manuel Garrido,
• Jochen Weishaupt,
• ...
• Mathias Bähr,
• Fred Lühder,
• Sebastian Kügler

Bisphosphonates Cause Osteonecrosis of the Jaw-Like Disease in Mice

• Yanming Bi,
• Yamei Gao,
• Driss Ehirchiou,
• ...
• Anh Le,
• Songtao Shi,
• Li Zhang

Statin Therapy and the Expression of Genes that Regulate Calcium Homeostasis and Membrane Repair in Skeletal Muscle

• Annette Draeger,
• Verónica Sanchez-Freire,
• Katia Monastyrskaya,
• ...
• Fabio Breil,
• Markus G. Mohaupt,
• Eduard B. Babiychuk

Oligemic Hypoperfusion Differentially Affects Tau and Amyloid-β

• Maya A. Koike,
• Kim N. Green,
• Mathew Blurton-Jones,
• Frank M. LaFerla

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging

• Zeshan Ahmed,
• Hong Sheng,
• Ya-fei Xu,
• ...
• Eileen McGowan,
• Dennis W. Dickson,
• Jada Lewis

Neuronal and Axonal Loss Are Selectively Linked to Fibrillar Amyloid-β within Plaques of the Aged Primate Cerebral Cortex

• Palak Shah,
• Neeta Lal,
• Elaine Leung,
• David E. Traul,
• Alicia Gonzalo-Ruiz,
• Changiz Geula

miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease

• Wang-Xia Wang,
• Bernard R. Wilfred,
• Sindhu K. Madathil,
• ...
• Qingwei Huang,
• Kathryn E. Saatman,
• Peter T. Nelson

Suppressed Accumulation of Cerebral Amyloid β Peptides in Aged Transgenic Alzheimer’s Disease Mice by Transplantation with Wild-Type or Prostaglandin E₂ Receptor Subtype 2-Null Bone Marrow

• C. Dirk Keene,
• Rubens C. Chang,
• Americo H. Lopez-Yglesias,
• ...
• Richard M. Breyer,
• Jason K. Rockhill,
• Thomas J. Montine

Methamphetamine Increases Brain Viral Load and Activates Natural Killer Cells in Simian Immunodeficiency Virus-Infected Monkeys

• Maria Cecilia Garibaldi Marcondes,
• Claudia Flynn,
• Debbie D. Watry,
• Michelle Zandonatti,
• Howard S. Fox

Tracheal Basal Cells

A Facultative Progenitor Cell Pool

• Brook B. Cole,
• Russell W. Smith,
• Kimberly M. Jenkins,
• Brian B. Graham,
• Paul R. Reynolds,
• Susan D. Reynolds

Down-Regulation of CD9 Expression and its Correlation to Tumor Progression in B Lymphomas

• Sun-Ok Yoon,
• Xin Zhang,
• Arnold S. Freedman,
• ...
• Izidore S. Lossos,
• Li Li,
• Yong Sung Choi

Metastatic Outgrowth Encompasses COL-I, FN1, and POSTN Up-Regulation and Assembly to Fibrillar Networks Regulating Cell Adhesion, Migration, and Growth

• Johanna Soikkeli,
• Piotr Podlasz,
• Miao Yin,
• ...
• Karl von Smitten,
• Olli Saksela,
• Erkki Hölttä

Sonic Hedgehog Acts as a Negative Regulator of β-Catenin Signaling in the Adult Tongue Epithelium

• Fabian T. Schneider,
• Anne Schänzer,
• Cathrin J. Czupalla,
• ...
• Mirko H.H. Schmidt,
• Karl H. Plate,
• Stefan Liebner

Met Activation in Non-Small Cell Lung Cancer Is Associated with de Novo Resistance to EGFR Inhibitors and the Development of Brain Metastasis

• Elisa Benedettini,
• Lynette M. Sholl,
• Michael Peyton,
• ...
• Lucian R. Chirieac,
• Bart Lutterbach,
• Massimo Loda

Tumor-Associated Retinal Astrocytes Promote Retinoblastoma Cell Proliferation Through Production of IGFBP-5

• Xiaoliang L. Xu,
• Thomas C. Lee,
• Nneka Offor,
• ...
• Suresh C. Jhanwar,
• David H. Abramson,
• David Cobrinik

Tumor Necrosis Factor-Induced Neutrophil Adhesion Occurs Via Sphingosine Kinase-1-Dependent Activation of Endothelial α₅β₁ Integrin

• Wai Y. Sun,
• Stuart M. Pitson,
• Claudine S. Bonder

High Glucose Disrupts Mitochondrial Morphology in Retinal Endothelial Cells

Implications for Diabetic Retinopathy

• Kyle Trudeau,
• Anthony J.A. Molina,
• Wen Guo,
• Sayon Roy

Cystatin C Deficiency Promotes Inflammation in Angiotensin II–Induced Abdominal Aortic Aneurisms in Atherosclerotic Mice

• Stephanie Schulte,
• Jiusong Sun,
• Peter Libby,
• ...
• Marco Lopez-Ilasaca,
• Guo-Ping Shi,
• Galina K. Sukhova

CD4⁺ Regulatory T Cells Generated in Vitro with IFN-γ and Allogeneic APC Inhibit Transplant Arteriosclerosis

• Gregor Warnecke,
• Gang Feng,
• Ryoichi Goto,
• ...
• Ross Francis,
• Kathryn J. Wood,
• Andrew Bushell

Myeloid CD34⁺CD13⁺ Precursor Cells Transdifferentiate into Chondrocyte-Like Cells in Atherosclerotic Intimal Calcification

• Lars Christian Doehring,
• Christian Heeger,
• Zouhair Aherrahrou,
• ...
• Jeanette Erdmann,
• Heribert Schunkert,
• Eva-Maria Ehlers

Resveratrol Regulates Pathologic Angiogenesis by a Eukaryotic Elongation Factor-2 Kinase-Regulated Pathway

• Aslam A. Khan,
• Dru S. Dace,
• Alexey G. Ryazanov,
• Jennifer Kelly,
• Rajendra S. Apte

Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE^−/− Mice

• Pierre Rotzius,
• Sebastian Thams,
• Oliver Soehnlein,
• ...
• Karl-Johan Malmberg,
• Lennart Lindbom,
• Einar E. Eriksson

Genetic Heterogeneity of Lymphangiogenesis in Different Mouse Strains

• Birgit Regenfuß,
• Jasmine Onderka,
• Felix Bock,
• Deniz Hos,
• Kazuichi Maruyama,
• Claus Cursiefen

Atheromas Feel the Pressure

Biomechanical Stress and Atherosclerosis

• Amy L. Pyle,
• Pampee P. Young