June 2010

On the Stem Cell Origin of Cancer

• Stewart Sell

Pathogenesis of Middle Ear Cholesteatoma

A New Model of Experimentally Induced Cholesteatoma in Mongolian Gerbils

• Tomomi Yamamoto-Fukuda,
• Yoshitaka Hishikawa,
• Yasuaki Shibata,
• Toshimitsu Kobayashi,
• Haruo Takahashi,
• Takehiko Koji

The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers

• Elodie E. Noel,
• Marc Yeste-Velasco,
• Xueying Mao,
• ...
• Daniel M. Berney,
• Simon P. Joel,
• Yong-Jie Lu

2p24 Gain Region Harboring MYCN Gene Compared with MYCN Amplified and Nonamplified Neuroblastoma

Biological and Clinical Characteristics

• Marta Jeison,
• Shifra Ash,
• Gili Halevy-Berko,
• ...
• Jerry Stein,
• Batia Stark,
• Isaac Yaniv

Pathologic Caveolin-1 Regulation of PTEN in Idiopathic Pulmonary Fibrosis

• Hong Xia,
• Wajahat Khalil,
• Judy Kahm,
• Jose Jessurun,
• Jill Kleidon,
• Craig A. Henke

Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2

• Habib Derbali,
• Yohan Bossé,
• Nancy Côté,
• ...
• Christian Couture,
• Jean-Pierre Després,
• Patrick Mathieu

Loss of Negative Feedback Control of Nuclear Factor-κB2 Activity in Lymphocytes Leads to Fatal Lung Inflammation

• Liqun Yang,
• Hongjuan Cui,
• Zhe Wang,
• ...
• Jane Ding,
• Lin Liu,
• Han-Fei Ding

Cardiotoxicity of the Anticancer Therapeutic Agent Bortezomib

• Dominika Nowis,
• Michał Mączewski,
• Urszula Mackiewicz,
• ...
• Jerzy Duszyński,
• Marek Jakóbisiak,
• Jakub Golab

RNA Interference Against Hepatic Epidermal Growth Factor Receptor Has Suppressive Effects on Liver Regeneration in Rats

• Shirish Paranjpe,
• William C. Bowen,
• George C. Tseng,
• Jian-Hua Luo,
• Anne Orr,
• George K. Michalopoulos

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

• Veronique E. Miron,
• Samuel K. Ludwin,
• Peter J. Darlington,
• ...
• Betty Soliven,
• Timothy E. Kennedy,
• Jack P. Antel

A Highly Toxic Cellular Prion Protein Induces a Novel, Nonapoptotic Form of Neuronal Death

• Heather M. Christensen,
• Krikor Dikranian,
• Aimin Li,
• ...
• John W. Olney,
• Kevin A. Roth,
• David A. Harris

17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α

• Stephen C. Gilliver,
• Elaine Emmerson,
• Laura Campbell,
• Pierre Chambon,
• Matthew J. Hardman,
• Gillian S. Ashcroft

A Novel Three-Dimensional Culture System of Polarized Epithelial Cells to Study Endometrial Carcinogenesis

• Núria Eritja,
• David Llobet,
• Mónica Domingo,
• ...
• Andree Yeramian,
• Xavier Matias-Guiu,
• Xavi Dolcet

The Role of the Wnt Family of Secreted Proteins in Rat Oval “Stem” Cell-Based Liver Regeneration

Wnt1 Drives Differentiation

• Jennifer M. Williams,
• Seh-Hoon Oh,
• Marda Jorgensen,
• ...
• Houda Darwiche,
• Thomas Shupe,
• Bryon E. Petersen

Hepatic Fibrosis Is Enhanced and Accompanied by Robust Oval Cell Activation after Chronic Carbon Tetrachloride Administration to Egr-1-Deficient Mice

• Michele T. Pritchard,
• Laura E. Nagy

An Immunocompromised Murine Model of Chronic Bartonella Infection

• Lucius Chiaraviglio,
• Scott Duong,
• Daniel A. Brown,
• Richard J. Birtles,
• James E. Kirby

Antigen-Specific CD25⁻Foxp3⁻IFN-γ^highCD4⁺ T Cells Restrain the Development of Experimental Allergic Encephalomyelitis by Suppressing Th17

• Gizi Wildbaum,
• Yaniv Zohar,
• Nathan Karin

HIV and SIV Induce Alterations in CNS CaMKII Expression and Activation

A Potential Mechanism for Cognitive Impairment

• Ravi G. Gupta,
• Kathleen M. Kelly,
• Kris L. Helke,
• ...
• Patrick M. Tarwater,
• Dennis L. Kolson,
• Joseph L. Mankowski

Pathogenesis of Chronic Wasting Disease in Cervidized Transgenic Mice

• Davis M. Seelig,
• Gary L. Mason,
• Glenn C. Telling,
• Edward A. Hoover

Abundant Expression of HIV Target Cells and C-Type Lectin Receptors in the Foreskin Tissue of Young Kenyan Men

• Taha Hirbod,
• Robert C. Bailey,
• Kawango Agot,
• ...
• Jan Andersson,
• Jakob Nilsson,
• Kristina Broliden

Type-I IFN Signaling Suppresses an Excessive IFN-γ Response and Thus Prevents Lung Damage and Chronic Inflammation During Pneumocystis (PC) Clearance in CD4 T Cell-Competent Mice

• Nicole Meissner,
• Steve Swain,
• Kate McInnerney,
• Soo Han,
• Allen G. Harmsen

Mechanisms of HIV-tat-Induced Phosphorylation of N-Methyl-d-Aspartate Receptor Subunit 2A in Human Primary Neurons

Implications for NeuroAIDS Pathogenesis

• Jessie E. King,
• Eliseo A. Eugenin,
• Joy E. Hazleton,
• Susan Morgello,
• Joan W. Berman

Heme Oxygenase-1 Expression in Murine Dendritic Cell Subpopulations

Effect on CD8⁺ Dendritic Cell Differentiation in Vivo

• Dong Jun Park,
• Anupam Agarwal,
• James F. George

4SC-101, A Novel Small Molecule Dihydroorotate Dehydrogenase Inhibitor, Suppresses Systemic Lupus Erythematosus in MRL-(Fas)lpr Mice

• Onkar P. Kulkarni,
• Sufyan G. Sayyed,
• Claudia Kantner,
• ...
• Aldo Ammendola,
• Robert Doblhofer,
• Hans-Joachim Anders

Bacterial Lipoproteins Can Disseminate from the Periphery to Inflame the Brain

• Diana Londoño,
• Diego Cadavid

RECK Is Up-Regulated and Involved in Chondrocyte Cloning in Human Osteoarthritic Cartilage

• Tokuhiro Kimura,
• Aiko Okada,
• Taku Yatabe,
• ...
• Yoshiaki Toyama,
• Makoto Noda,
• Yasunori Okada

Proinflammatory Cytokines Are Involved in the Initiation of the Abnormal Matrix Process in Pseudoexfoliation Syndrome/Glaucoma

• Matthias Zenkel,
• Piotr Lewczuk,
• Anselm Jünemann,
• Friedrich E. Kruse,
• Gottfried O.H. Naumann,
• Ursula Schlötzer-Schrehardt

Expression of Myocilin Mutants Sensitizes Cells to Oxidative Stress-Induced Apoptosis

Implication for Glaucoma Pathogenesis

• Myung Kuk Joe,
• Stanislav I. Tomarev

Inflammasome Up-Regulation and Activation in Dysferlin-Deficient Skeletal Muscle

• Rashmi Rawat,
• Tatiana V. Cohen,
• Beryl Ampong,
• ...
• Andrea Henriques-Pons,
• Eric P. Hoffman,
• Kanneboyina Nagaraju

DNAJB2 Expression in Normal and Diseased Human and Mouse Skeletal Muscle

• Kristl G. Claeys,
• Magdalena Sozanska,
• Jean-Jacques Martin,
• ...
• Daniel Scherman,
• Thomas Voit,
• David Israeli

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

• Andrey I. Khramtsov,
• Galina F. Khramtsova,
• Maria Tretiakova,
• Dezheng Huo,
• Olufunmilayo I. Olopade,
• Kathleen H. Goss

O-Fucose Modulates Notch-Controlled Blood Lineage Commitment

• Quanjian Yan,
• David Yao,
• Lebing L. Wei,
• ...
• Stanton Gerson,
• John B. Lowe,
• Lan Zhou

Significance of the Fanconi Anemia FANCD2 Protein in Sporadic and Metastatic Human Breast Cancer

• Philip S. Rudland,
• Angela M. Platt-Higgins,
• Lowri M. Davies,
• ...
• Roger Barraclough,
• Christopher R. West,
• Nigel J. Jones

Macrophage Inhibitory Cytokine-1 Regulates Melanoma Vascular Development

• Sung Jin Huh,
• Chin-Ying Chung,
• Arati Sharma,
• Gavin P. Robertson

Capturing Changes in the Brain Microenvironment during Initial Steps of Breast Cancer Brain Metastasis

• Mihaela Lorger,
• Brunhilde Felding-Habermann

Tumor Progression Stage and Anatomical Site Regulate Tumor-Associated Macrophage and Bone Marrow-Derived Monocyte Polarization

• Elizabeth F. Redente,
• Lori D. Dwyer-Nield,
• Daniel T. Merrick,
• ...
• Pamela L. Rice,
• Kenneth R. Shroyer,
• Alvin M. Malkinson

TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells

• Ya-Wen Chen,
• Ming-Shyue Lee,
• Amanda Lucht,
• ...
• Toni M. Antalis,
• Michael D. Johnson,
• Chen-Yong Lin

The Insulin-Like Growth Factor Receptor I Promotes Motility and Invasion of Bladder Cancer Cells through Akt- and Mitogen-Activated Protein Kinase-Dependent Activation of Paxillin

• David Metalli,
• Francesca Lovat,
• Farida Tripodi,
• ...
• Leonard G. Gomella,
• Renato V. Iozzo,
• Andrea Morrione

A Role for the Epithelial Microenvironment at Tumor Boundaries

Evidence from Drosophila and Human Squamous Cell Carcinomas

• Marcos Vidal,
• Lorena Salavaggione,
• Lourdes Ylagan,
• ...
• Mark Watson,
• Katherine Weilbaecher,
• Ross Cagan

p21-Activated Kinase-1 Promotes Aggressive Phenotype, Cell Proliferation, and Invasion in Gestational Trophoblastic Disease

• Michelle K.Y. Siu,
• Matthew C.W. Yeung,
• HuiJuan Zhang,
• ...
• Hextan Y.S. Ngan,
• Dominic C.W. Chan,
• Annie N.Y. Cheung

Overexpression of Galectin-7, A Myoepithelial Cell Marker, Enhances Spontaneous Metastasis of Breast Cancer Cells

• Mélanie Demers,
• April A.N. Rose,
• Andrée-Anne Grosset,
• ...
• Louis Gaboury,
• Peter M. Siegel,
• Yves St-Pierre

An Extensive Invasive Intracranial Human Glioblastoma Xenograft Model

Role of High Level Matrix Metalloproteinase 9

• Yunge Zhao,
• Aizhen Xiao,
• Charles G. diPierro,
• ...
• Gerard T. Redpath,
• Maria-Beatriz S. Lopes,
• Isa M. Hussaini

Podocalyxin EBP50 Ezrin Molecular Complex Enhances the Metastatic Potential of Renal Cell Carcinoma Through Recruiting Rac1 Guanine Nucleotide Exchange Factor ARHGEF7

• Yung-Ho Hsu,
• Wei-Ling Lin,
• Yi-Ting Hou,
• ...
• Jen-Yau Chen,
• Tso-Hsiao Chen,
• Tzuu-Shuh Jou

Mammalian Target of Rapamycin (mTOR) Regulates Cellular Proliferation and Tumor Growth in Urothelial Carcinoma

• Donna E. Hansel,
• Eric Platt,
• Mohammed Orloff,
• ...
• Dan Theodorescu,
• Christina B. Ching,
• Charis Eng

Atherosclerotic Lesion Progression Changes Lysophosphatidic Acid Homeostasis to Favor its Accumulation

• Martine Bot,
• Ilze Bot,
• Rubén Lopez-Vales,
• ...
• Samuel David,
• Theo J.C. van Berkel,
• Erik A.L. Biessen

A Rat Model for Choroidal Neovascularization Using Subretinal Lipid Hydroperoxide Injection

• Takayuki Baba,
• Imran A. Bhutto,
• Carol Merges,
• ...
• D. Scott McLeod,
• Donald Armstrong,
• Gerard A. Lutty