June 2011

Biomarkers, Genomics, Proteomics, and Gene Regulation

BAG3 Protein Is Overexpressed in Human Glioblastoma and Is a Potential Target for Therapy
• Michelina Festa,
• Luis Del Valle,
• Kamel Khalili,
• ...
• Vincenzo De Laurenzi,
• Maria Caterina Turco,
• Alessandra Rosati
Published online: May 12, 2011
p2504-2512

Use of Gene Expression and Pathway Signatures to Characterize the Complexity of Human Melanoma
• Jennifer A. Freedman,
• Douglas S. Tyler,
• Joseph R. Nevins,
• Christina K. Augustine
Published in issue: June 2011
p2513-2522

Biophysical Imaging and Computational Biology

Noninvasive Imaging Technologies Reveal Edema Toxin as a Key Virulence Factor in Anthrax
• Fabien Dumetz,
• Grégory Jouvion,
• Huot Khun,
• ...
• Michèle Mock,
• Michel Huerre,
• Pierre Louis Goossens
Published in issue: June 2011
p2523-2535

Cardiovascular, Pulmonary, and Renal Pathology

Spontaneous Lung Dysfunction and Fibrosis in Mice Lacking Connexin 40 and Endothelial Cell Connexin 43
• Michael Koval,
• Marie Billaud,
• Adam C. Straub,
• ...
• Alexander Zarbock,
• Brian R. Duling,
• Brant E. Isakson
Published in issue: June 2011
p2536-2546

Selective Regulation of Cardiac Organic Cation Transporter Novel Type 2 (OCTN2) in Dilated Cardiomyopathy
• Markus Grube,
• Sabine Ameling,
• Michel Noutsias,
• ...
• Karin Klingel,
• Reinhard Kandolf,
• Heyo K. Kroemer
Published in issue: June 2011
p2547-2559

Direct Leukocyte Migration across Pulmonary Arterioles and Venules into the Perivascular Interstitium of Murine Lungs during Bleomycin Injury and Repair
• Ping M. Wang,
• Diane L. Kachel,
• Mark F. Cesta,
• William J. Martin II
Published in issue: June 2011
p2560-2572

Blockade of TSP1-Dependent TGF-β Activity Reduces Renal Injury and Proteinuria in a Murine Model of Diabetic Nephropathy
• Ailing Lu,
• Mi Miao,
• Trenton R. Schoeb,
• Anupam Agarwal,
• Joanne E. Murphy-Ullrich
Published in issue: June 2011
p2573-2586

Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura
• Fiona A. Murphy,
• Craig A. Poland,
• Rodger Duffin,
• ...
• William A. Wallace,
• Kostas Kostarelos,
• Ken Donaldson
Published in issue: June 2011
p2587-2600

Neonatal Hyperoxia Causes Pulmonary Vascular Disease and Shortens Life Span in Aging Mice
• Min Yee,
• R. James White,
• Hani A. Awad,
• Wendy A. Bates,
• Sharon A. McGrath-Morrow,
• Michael A. O'Reilly
Published online: May 09, 2011
p2601-2610

Cell Injury, Repair, Aging, and Apoptosis

Inhibiting TGF-β Activity Improves Respiratory Function in mdx Mice
• Carol A. Nelson,
• R. Bridge Hunter,
• Lindsay A. Quigley,
• ...
• Seng H. Cheng,
• John P. Leonard,
• Bruce M. Wentworth
Published in issue: June 2011
p2611-2621

Fussel-15, a New Player in Wound Healing, Is Deregulated in Keloid and Localized Scleroderma
• Stephanie Arndt,
• Johanna Schmidt,
• Eva Wacker,
• Sigrid Karrer,
• Anja-Katrin Bosserhoff
Published in issue: June 2011
p2622-2631

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition
• Catherine A. Jurgens,
• Mirna N. Toukatly,
• Corinne L. Fligner,
• ...
• Gunilla T. Westermark,
• Steven E. Kahn,
• Rebecca L. Hull
Published in issue: June 2011
p2632-2640

Apoptosis-Like Cell Death Induction and Aberrant Fibroblast Properties in Human Incisional Hernia Fascia
• Ramon Diaz,
• Maria T. Quiles,
• Jordi Guillem-Marti,
• ...
• Jaume Reventos,
• Manel Armengol,
• Maria A. Arbos
Published in issue: June 2011
p2641-2653

Epithelial and Mesenchymal Cell Biology

TRPV1 Involvement in Inflammatory Tissue Fibrosis in Mice
• Yuka Okada,
• Peter S. Reinach,
• Kumi Shirai,
• ...
• Hongshan Liu,
• Jianhua Zhang,
• Shizuya Saika
Published in issue: June 2011
p2654-2664

Angiotensin II–Induced MMP-2 Activity and MMP-14 and Basigin Protein Expression Are Mediated via the Angiotensin II Receptor Type 1–Mitogen-Activated Protein Kinase 1 Pathway in Retinal Pigment Epithelium
Implications for Age-Related Macular Degeneration
• Marianne Pons,
• Scott W. Cousins,
• Oscar Alcazar,
• Gary E. Striker,
• Maria E. Marin-Castaño
Published in issue: June 2011
p2665-2681

Gastrointestinal, Hepatobiliary, and Pancreatic Pathology

Characterization of the Cysteinyl Leukotriene 2 Receptor in Novel Expression Sites of the Gastrointestinal Tract
• Alma Barajas-Espinosa,
• Fernando Ochoa-Cortes,
• Michael P. Moos,
• F. Daniel Ramirez,
• Stephen J. Vanner,
• Colin D. Funk
Published in issue: June 2011
p2682-2689

Adiponectin Regulation of Stellate Cell Activation via PPARγ-Dependent and -Independent Mechanisms
• Mahnoush S. Shafiei,
• Shoba Shetty,
• Philipp E. Scherer,
• Don C. Rockey
Published in issue: June 2011
p2690-2699

A Serrated Colorectal Cancer Pathway Predominates over the Classic WNT Pathway in Patients with Hyperplastic Polyposis Syndrome
• Karam S. Boparai,
• Evelien Dekker,
• Mirjam M. Polak,
• Alex R. Musler,
• Susanne van Eeden,
• Carel J.M. van Noesel
Published in issue: June 2011
p2700-2707

Changes in Autophagic Response in Patients with Chronic Hepatitis C Virus Infection
• Pierre-Emmanuel Rautou,
• Dominique Cazals-Hatem,
• Gérard Feldmann,
• ...
• Dominique Valla,
• Tarik Asselah,
• Richard Moreau
Published in issue: June 2011
p2708-2715

Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes
• Kate L. Graham,
• Balasubramanian Krishnamurthy,
• Stacey Fynch,
• ...
• Pere Santamaria,
• Thomas W. Kay,
• Helen E. Thomas
Published in issue: June 2011
p2716-2725

Immunopathology and Infectious Diseases

Borrelia burgdorferi RST1 (OspC Type A) Genotype Is Associated with Greater Inflammation and More Severe Lyme Disease
• Klemen Strle,
• Kathryn L. Jones,
• Elise E. Drouin,
• Xin Li,
• Allen C. Steere
Published in issue: June 2011
p2726-2739

Aberrant CD8⁺ T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling
• Anthony D. D'Souza,
• Ian A. Parish,
• Sharen E. McKay,
• Susan M. Kaech,
• Gerald S. Shadel
Published in issue: June 2011
p2740-2751


Extracellular Superoxide Dismutase in Macrophages Augments Bacterial Killing by Promoting Phagocytosis
• Michelle L. Manni,
• Lauren P. Tomai,
• Callie A. Norris,
• ...
• Simon C. Watkins,
• Jon D. Piganelli,
• Tim D. Oury
Published in issue: June 2011
p2752-2759

Human Leukocyte Antigen Class II Transgenic Mouse Model Unmasks the Significant Extrahepatic Pathology in Toxic Shock Syndrome
• Ashenafi Y. Tilahun,
• Eric V. Marietta,
• Tsung-Teh Wu,
• Robin Patel,
• Chella S. David,
• Govindarajan Rajagopalan
Published in issue: June 2011
p2760-2773

Role of p47phox in Antigen-Presenting Cell-Mediated Regulation of Humoral Immunity in Mice
• Sam Vasilevsky,
• Qi Liu,
• Sherry M. Koontz,
• Robin Kastenmayer,
• Katherine Shea,
• Sharon H. Jackson
Published in issue: June 2011
p2774-2782

Systemic Low-Dose UVB Inhibits CD8 T Cells and Skin Inflammation by Alternative and Novel Mechanisms
• Sabita Rana,
• Linda Joanne Rogers,
• Gary Mark Halliday
Published in issue: June 2011
p2783-2791

Effect of Macrophage Migration Inhibitory Factor (MIF) in Human Placental Explants Infected with Toxoplasma gondii Depends on Gestational Age
• Angelica de Oliveira Gomes,
• Deise Aparecida de Oliveira Silva,
• Neide Maria Silva,
• ...
• Maria Célia dos Santos,
• José Roberto Mineo,
• Eloisa Amália Vieira Ferro
Published in issue: June 2011
p2792-2801

Placental TNF-α Signaling in Illness-Induced Complications of Pregnancy
• Pamela A. Carpentier,
• Andra L. Dingman,
• Theo D. Palmer
Published in issue: June 2011
p2802-2810

Neurobiology

Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice
• Michael Sy,
• Masashi Kitazawa,
• Rodrigo Medeiros,
• ...
• David Cheng,
• Thomas E. Lane,
• Frank M. LaFerla
Published online: May 02, 2011
p2811-2822

Neuroprotective Effects of the Cellular Prion Protein in Autoimmune Optic Neuritis
• Sarah K. Williams,
• Richard Fairless,
• Jens Weise,
• Ulrich Kalinke,
• Walter Schulz-Schaeffer,
• Ricarda Diem
Published in issue: June 2011
p2823-2831

Stem Cells, Tissue Engineering, and Hematopoietic Elements

Identification of Cells with Colony-Forming Activity, Self-Renewal Capacity, and Multipotency in Ovarian Endometriosis
• Rachel Wah Shan Chan,
• Ernest Hung Yu Ng,
• William Shu Biu Yeung
Published in issue: June 2011
p2832-2844

Tumorigenesis and Neoplastic Progression

RANKL Expression Specifically Observed in Vivo Promotes Epithelial Mesenchymal Transition and Tumor Progression
• Tamaki Yamada,
• Masumi Tsuda,
• Tomomi Takahashi,
• Yasunori Totsuka,
• Masanobu Shindoh,
• Yusuke Ohba
Published online: May 12, 2011
p2845-2856

In Vivo Invasion of Head and Neck Squamous Cell Carcinoma Cells Does Not Require Macrophages
• Tatiana Smirnova,
• Alfred Adomako,
• Joseph Locker,
• Nico Van Rooijen,
• Michael B. Prystowsky,
• Jeffrey E. Segall
Published in issue: June 2011
p2857-2865


Secretory Leukocyte Protease Inhibitor (SLPI) Expression and Tumor Invasion in Oral Squamous Cell Carcinoma
• Jie Wen,
• Nikolaos G. Nikitakis,
• Risa Chaisuparat,
• ...
• Tanxia Wu,
• Gary Warburton,
• Sharon M. Wahl
Published in issue: June 2011
p2866-2878

Vascular Biology, Atherosclerosis, and Endothelium Biology

Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries
• Ruben B. Roijers,
• Nicola Debernardi,
• Jack P.M. Cleutjens,
• Leon J. Schurgers,
• Peter H.A. Mutsaers,
• Ger J. van der Vusse
Published online: May 02, 2011
p2879-2887

Glyceryl Trinitrate Inhibits Hypoxia-Induced Release of Soluble fms-Like Tyrosine Kinase-1 and Endoglin from Placental Tissues
• Ivraym B. Barsoum,
• Stephen J. Renaud,
• Charles H. Graham
Published in issue: June 2011
p2888-2896

Pericyte Requirement for Anti-Leak Action of Angiopoietin-1 and Vascular Remodeling in Sustained Inflammation
• Jonas Fuxe,
• Sébastien Tabruyn,
• Katharine Colton,
• ...
• David M. Epstein,
• Gou Young Koh,
• Donald M. McDonald
Published online: May 09, 2011
p2897-2909

Mouse Vein Graft Hemodynamic Manipulations to Enhance Experimental Utility
• Peng Yu,
• Binh T. Nguyen,
• Ming Tao,
• Yingnan Bai,
• C. Keith Ozaki
Published in issue: June 2011
p2910-2919

Increased Vascular Delivery and Efficacy of Chemotherapy after Inhibition of Platelet-Derived Growth Factor-B
• Beverly L. Falcon,
• Kristian Pietras,
• Jeyling Chou,
• ...
• Barbara Sennino,
• Douglas Hanahan,
• Donald M. McDonald
Published in issue: June 2011
p2920-2930

Hematopoietic Fas Deficiency Does Not Affect Experimental Atherosclerotic Lesion Formation despite Inducing a Proatherogenic State
• R. Angelo de Claro,
• Xiaodong Zhu,
• Jingjing Tang,
• ...
• W. Conrad Liles,
• Elaine W. Raines,
• John M. Harlan
Published online: May 09, 2011
p2931-2937

Redistribution and Hemostatic Action of Recombinant Activated Factor VII Associated with Platelets
• Irene Lopez-Vilchez,
• Ulla Hedner,
• Carmen Altisent,
• Maribel Diaz-Ricart,
• Gines Escolar,
• Ana M. Galan
Published in issue: June 2011
p2938-2948