August 2011

This Month in AJP

This Month in AJP
Published online: June 27, 2011
p539

Short Communications

KISS1 Methylation and Expression as Tumor Stratification Biomarkers and Clinical Outcome Prognosticators for Bladder Cancer Patients
• Virginia Cebrian,
• Marta Fierro,
• Esteban Orenes-Piñero,
• ...
• James Catto,
• Antonio López-Beltrán,
• Marta Sánchez-Carbayo
Published online: June 20, 2011
p540-546

Rational Variety Mapping for Contrast-Enhanced Nonlinear Unsupervised Segmentation of Multispectral Images of Unstained Specimen
• Ivica Kopriva,
• Mirko Hadžija,
• Marijana Popović Hadžija,
• Marina Korolija,
• Andrzej Cichocki
Published online: June 27, 2011
p547-554

Regular Articles

Biomarkers, Genomics, Proteomics, and Gene Regulation


Survivin Is a Novel Target of CD44-Promoted Breast Tumor Invasion
• Mohamed E. Abdraboh,
• Rajiv L. Gaur,
• Andrew D. Hollenbach,
• Dane Sandquist,
• Madhwa H.G. Raj,
• Allal Ouhtit
Published online: June 16, 2011
p555-563

Expression of Endoplasmic Reticulum Stress Proteins Is a Candidate Marker of Brain Metastasis in both ErbB-2⁺ and ErbB-2⁻ Primary Breast Tumors
• Rebeca Sanz-Pamplona,
• Ramón Aragüés,
• Keltouma Driouch,
• ...
• Fabien Reyal,
• Marc J. Van de Vijver,
• Angels Sierra
Published online: June 27, 2011
p564-579

Standardization of Epidermal Growth Factor Receptor (EGFR) Measurement by Quantitative Immunofluorescence and Impact on Antibody-Based Mutation Detection in Non–Small Cell Lung Cancer
• Anastasios Dimou,
• Seema Agarwal,
• Valsamo Anagnostou,
• ...
• Vassiliki Zolota,
• Konstantinos Syrigos,
• David L. Rimm
Published online: June 13, 2011
p580-589

miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue in Human Trophoblast Cell Lines
Siderosis of Interstitial Trophoblasts as a Novel Pathology of Preterm Preeclampsia and Small-for-Gestational-Age Pregnancies
• Deug-Chan Lee,
• Roberto Romero,
• Jung-Sun Kim,
• ...
• Tinnakorn Chaiworapongsa,
• Sonia S. Hassan,
• Chong Jai Kim
Published in issue: August 2011
p590-602

Biophysical Imaging and Computational Biology


Spatiotemporal and Functional Behavior of Airway Dendritic Cells Visualized by Two-Photon Microscopy
• Tibor Zoltán Veres,
• Sabrina Voedisch,
• Emma Spies,
• Thomas Tschernig,
• Armin Braun
Published online: June 27, 2011
p603-609

Visualization of Mouse Pancreas Architecture Using MR Microscopy
• Paul J. Grippo,
• Palamadai N. Venkatasubramanian,
• Richard H. Knop,
• ...
• Morgan R. Barron,
• David J. Bentrem,
• Alice M. Wyrwicz
Published online: May 30, 2011
p610-618

Cardiovascular, Pulmonary, and Renal Pathology


Intermediate Volume on Computed Tomography Imaging Defines a Fibrotic Compartment that Predicts Glomerular Filtration Rate Decline in Autosomal Dominant Polycystic Kidney Disease Patients
• Anna Caroli,
• Luca Antiga,
• Sara Conti,
• ...
• Norberto Perico,
• Giuseppe Remuzzi,
• Andrea Remuzzi
Published online: June 20, 2011
p619-627

Inhibiting Angiotensin-Converting Enzyme Promotes Renal Repair by Limiting Progenitor Cell Proliferation and Restoring the Glomerular Architecture
• Ariela Benigni,
• Marina Morigi,
• Paola Rizzo,
• ...
• Serena Ghezzi,
• Andrea Remuzzi,
• Giuseppe Remuzzi
Published online: June 06, 2011
p628-638

MicroRNAs Involved in the Mitogen-Activated Protein Kinase Cascades Pathway During Glucose-Induced Cardiomyocyte Hypertrophy
• E. Shen,
• Xuehong Diao,
• Xiaoxia Wang,
• Ruizhen Chen,
• Bing Hu
Published online: June 24, 2011
p639-650

Deficiency of a Transcriptional Regulator, Inhibitor of Differentiation 3, Induces Glomerulonephritis in Apolipoprotein E–Deficient Mice
A Model Linking Hyperlipidemia and Renal Disease
• Harini Bagavant,
• Yogesh Scindia,
• Dominika Nackiewicz,
• ...
• Stephanie Oldham,
• Umesh Deshmukh,
• Coleen McNamara
Published online: June 16, 2011
p651-660

miR-21 and miR-214 Are Consistently Modulated during Renal Injury in Rodent Models
• Laura Denby,
• Vasudev Ramdas,
• Martin W. McBride,
• ...
• Anna F. Dominiczak,
• Claire C. Sharpe,
• Andrew H. Baker
Published online: May 30, 2011
p661-672

Cell Injury, Repair, Aging, and Apoptosis


Mu Opioid Signaling Protects Against Acute Murine Intestinal Injury in a Manner Involving Stat3 Signaling
• Jason R. Goldsmith,
• Joshua M. Uronis,
• Christian Jobin
Published online: June 13, 2011
p673-683

Altered Mitochondrial Function in Type 2 Granular Corneal Dystrophy
• Tae-im Kim,
• Hanna Kim,
• Doo Jae Lee,
• Seung-Il Choi,
• Sang Won Kang,
• Eung Kweon Kim
Published online: May 30, 2011
p684-692

Gastrointestinal, Hepatobiliary, and Pancreatic Pathology


Zinc Deprivation Mediates Alcohol-Induced Hepatocyte IL-8 Analog Expression in Rodents via an Epigenetic Mechanism
• Yantao Zhao,
• Wei Zhong,
• Xiuhua Sun,
• ...
• Y. James Kang,
• Craig J. McClain,
• Zhanxiang Zhou
Published online: June 06, 2011
p693-702

Progressive Endoplasmic Reticulum Stress Contributes to Hepatocarcinogenesis in Fatty Acyl-CoA Oxidase 1–Deficient Mice
• Jiansheng Huang,
• Navin Viswakarma,
• Songtao Yu,
• ...
• M. Sambasiva Rao,
• Jayme Borensztajn,
• Janardan K. Reddy
Published online: June 13, 2011
p703-713

Hepatoprotective versus Oncogenic Functions of STAT3 in Liver Tumorigenesis
• Hua Wang,
• Fouad Lafdil,
• Lei Wang,
• ...
• Andrew M. Miller,
• Zhaoli Sun,
• Bin Gao
Published online: June 03, 2011
p714-724

Immunopathology and Infectious Diseases


Inhibition of Fas Ligand in NOD Mice Unmasks a Protective Role for IL-10 against Insulitis Development
• Zuoxiang Xiao,
• Abdiaziz S. Mohamood,
• Sophia Uddin,
• ...
• Jonathan P. Schneck,
• Hideo Yagita,
• Abdel Rahim A. Hamad
Published online: June 17, 2011
p725-732

Eosinophils Contribute to IL-4 Production and Shape the T-Helper Cytokine Profile and Inflammatory Response in Pulmonary Cryptococcosis
• Daniel Piehler,
• Werner Stenzel,
• Andreas Grahnert,
• ...
• Maria Eschke,
• Gottfried Alber,
• Uwe Müller
Published online: May 30, 2011
p733-744


A Human-Mouse Chimeric Model of Obliterative Bronchiolitis after Lung Transplantation
• Jianmin Xue,
• Xuehai Zhu,
• M. Patricia George,
• ...
• Michael W. Stoner,
• Joseph W. Pilewski,
• Steven R. Duncan
Published online: June 09, 2011
p745-753

Manifestation of Spontaneous and Early Autoimmune Gastritis in CCR7-Deficient Mice
• Susann Winter,
• Armin Rehm,
• Katharina Wichner,
• ...
• Claudia Berek,
• Martin Lipp,
• Uta E. Höpken
Published online: June 13, 2011
p754-765

Complement Regulates CD4 T-Cell Help to CD8 T Cells Required for Murine Allograft Rejection
• Mark Vieyra,
• Staci Leisman,
• Hugo Raedler,
• ...
• Michael G. Strainic,
• M. Edward Medof,
• Peter S. Heeger
Published online: June 24, 2011
p766-774

FcεRI, but Not FcγR, Signals Induce Prostaglandin D2 and E2 Production from Basophils
• Tsukasa Ugajin,
• Takahiro Satoh,
• Toru Kanamori,
• Kosuke Aritake,
• Yoshihiro Urade,
• Hiroo Yokozeki
Published online: June 06, 2011
p775-782

TLR7 and TLR9 Trigger Distinct Neuroinflammatory Responses in the CNS
• Niranjan B. Butchi,
• Tyson Woods,
• Min Du,
• Timothy W. Morgan,
• Karin E. Peterson
Published online: June 16, 2011
p783-794

Pathogenic Relevance of IgG and IgM Antibodies against Desmoglein 3 in Blister Formation in Pemphigus Vulgaris
• Kazuyuki Tsunoda,
• Takayuki Ota,
• Masataka Saito,
• ...
• Taneaki Nakagawa,
• Andrew P. Kowalczyk,
• Masayuki Amagai
Published online: June 13, 2011
p795-806

Prostaglandin E₂ Produced by Entamoeba histolytica Signals via EP4 Receptor and Alters Claudin-4 to Increase Ion Permeability of Tight Junctions
• Manigandan Lejeune,
• France Moreau,
• Kris Chadee
Published online: May 30, 2011
p807-818

Plasmin Is Essential in Preventing Periodontitis in Mice
• Rima Sulniute,
• Tomas Lindh,
• Malgorzata Wilczynska,
• Jinan Li,
• Tor Ny
Published online: June 06, 2011
p819-828

Matrix Pathobiology


Dynamic Interactions of Epidermal Collagen XVII with the Extracellular Matrix
Laminin 332 as a Major Binding Partner
• Wataru Nishie,
• Dimitra Kiritsi,
• Alexander Nyström,
• Silke C. Hofmann,
• Leena Bruckner-Tuderman
Published online: June 16, 2011
p829-837

Complement Activation Triggers Metalloproteinases Release Inducing Cervical Remodeling and Preterm Birth in Mice
• Juan M. Gonzalez,
• Claus-Werner Franzke,
• Fengyuan Yang,
• Roberto Romero,
• Guillermina Girardi
Published online: June 13, 2011
p838-849

Advanced Glycation Endproduct Changes to Bruch's Membrane Promotes Lipoprotein Retention by Lipoprotein Lipase
• Marisol Cano,
• Natalia Fijalkowski,
• Naoshi Kondo,
• Sonny Dike,
• James Handa
Published online: June 13, 2011
p850-859

Astrocyte-Derived Thrombospondin-2 Is Critical for the Repair of the Blood-Brain Barrier
• Weiming Tian,
• Andrew Sawyer,
• Feriha B. Kocaoglu,
• Themis R. Kyriakides
Published online: June 06, 2011
p860-868

Metabolic, Endocrine, and Genitourinary Pathobiology


The Pathogenic Role of Cystathionine γ-Lyase/Hydrogen Sulfide in Streptozotocin-Induced Diabetes in Mice
• Guangdong Yang,
• Guanghua Tang,
• Ling Zhang,
• Lingyun Wu,
• Rui Wang
Published online: June 06, 2011
p869-879

The mTOR/AKT Inhibitor Temsirolimus Prevents Deep Infiltrating Endometriosis in Mice
• Mahaut Leconte,
• Carole Nicco,
• Charlotte Ngô,
• ...
• Charles Chapron,
• Bertrand Dousset,
• Frédéric Batteux
Published online: June 13, 2011
p880-889

Molecular Pathogenesis of Genetic and Inherited Diseases


Endosomal/Lysosomal Processing of Gangliosides Affects Neuronal Cholesterol Sequestration in Niemann-Pick Disease Type C
• Sharon Zhou,
• Cristin Davidson,
• Robert McGlynn,
• ...
• Kostantin Dobrenis,
• Marie T. Vanier,
• Steven U. Walkley
Published online: June 06, 2011
p890-902

An ENU-Induced Mutation of Cdh23 Causes Congenital Hearing Loss, but No Vestibular Dysfunction, in Mice
• Shehnaaz S.M. Manji,
• Kerry A. Miller,
• Louise H. Williams,
• ...
• Melanie Bahlo,
• Michael Kuiper,
• Hans-Henrik M. Dahl
Published online: June 06, 2011
p903-914

Musculoskeletal Pathology


Follistatin Improves Skeletal Muscle Healing after Injury and Disease through an Interaction with Muscle Regeneration, Angiogenesis, and Fibrosis
• Jinhong Zhu,
• Yong Li,
• Aiping Lu,
• ...
• Tetsuo Kobayashi,
• Andres J. Quintero,
• Johnny Huard
Published online: May 30, 2011
p915-930

Slow-Adhering Stem Cells Derived from Injured Skeletal Muscle Have Improved Regenerative Capacity
• Xiaodong Mu,
• Guosheng Xiang,
• Christopher R. Rathbone,
• ...
• Ian H. Bellayr,
• Thomas J. Walters,
• Yong Li
Published online: June 06, 2011
p931-941

Neurobiology


Microglia/Macrophages Migrate through Retinal Epithelium Barrier by a Transcellular Route in Diabetic Retinopathy
Role of PKCζ in the Goto Kakizaki Rat Model
• Samy Omri,
• Francine Behar-Cohen,
• Yvonne de Kozak,
• ...
• Michèle Savoldelli,
• Boubaker Omri,
• Patricia Crisanti
Published online: June 06, 2011
p942-953

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons
• Nadia Stefanova,
• Lisa Fellner,
• Markus Reindl,
• Eliezer Masliah,
• Werner Poewe,
• Gregor K. Wenning
Published online: June 16, 2011
p954-963

Dual Functionality of Myeloperoxidase in Rotenone-Exposed Brain-Resident Immune Cells
• Chi Young Chang,
• Mi Jeon Song,
• Sae-Bom Jeon,
• ...
• Kyungho Suk,
• Dong-Kug Choi,
• Eun Jung Park
Published online: June 24, 2011
p964-979

Loss of Muscarinic M₁ Receptor Exacerbates Alzheimer's Disease–Like Pathology and Cognitive Decline
• Rodrigo Medeiros,
• Masashi Kitazawa,
• Antonella Caccamo,
• ...
• David H. Cribbs,
• Avraham Fisher,
• Frank M. LaFerla
Published online: June 24, 2011
p980-991

Tumorigenesis and Neoplastic Progression


The Role of Pea3 Group Transcription Factors in Esophageal Squamous Cell Carcinoma
• Hiu-Fung Yuen,
• Cian M. McCrudden,
• Ka-Kui Chan,
• ...
• Terence R. Lappin,
• Kwok-Wah Chan,
• Mohamed El-Tanani
Published online: May 30, 2011
p992-1003


An Extensive Tumor Array Analysis Supports Tumor Suppressive Role for Nucleophosmin in Breast Cancer
• Piia-Riitta Karhemo,
• Antti Rivinoja,
• Johan Lundin,
• ...
• Heikki Joensuu,
• Petri Bono,
• Pirjo Laakkonen
Published online: June 06, 2011
p1004-1014

Keratin 19 Epithelial Patterns in Cirrhotic Stroma Parallel Hepatocarcinogenesis
• Jochen K.M. Lennerz,
• William C. Chapman,
• Elizabeth M. Brunt
Published online: June 24, 2011
p1015-1029

In Vivo and in Vitro Evidence That PPARγ Ligands Are Antagonists of Leptin Signaling in Breast Cancer
• Stefania Catalano,
• Loredana Mauro,
• Daniela Bonofiglio,
• ...
• Donatella Vizza,
• Gianluca Bossi,
• Sebastiano Andò
Published online: June 24, 2011
p1030-1040

Podoplanin Is Regulated by AP-1 and Promotes Platelet Aggregation and Cell Migration in Osteosarcoma
• Akiko Kunita,
• Takeshi G. Kashima,
• Atsushi Ohazama,
• Agamemnon E. Grigoriadis,
• Masashi Fukayama
Published online: June 13, 2011
p1041-1049

Promotion of Liver and Lung Tumorigenesis in DEN-Treated Cytoglobin-Deficient Mice
• Le Thi Thanh Thuy,
• Takashi Morita,
• Kayo Yoshida,
• ...
• Kazuo Ikeda,
• Katsutoshi Yoshizato,
• Norifumi Kawada
Published online: June 06, 2011
p1050-1060

Statistical Association of Basal Cell Keratins with Metastasis-Inducing Proteins in a Prognostically Unfavorable Group of Sporadic Breast Cancers
• Suzete de Silva Rudland,
• Angela Platt-Higgins,
• John H.R. Winstanley,
• ...
• Christopher West,
• Joseph Carroll,
• Philip S. Rudland
Published online: June 16, 2011
p1061-1072