October 2011

Biomarkers, Genomics, Proteomics, and Gene Regulation

EGFR Expression Stratifies Oligodendroglioma Behavior
• Craig Horbinski,
• Jonathan Hobbs,
• Kathleen Cieply,
• Sanja Dacic,
• Ronald L. Hamilton
Published online: August 16, 2011
p1638-1644

The miR-17-92 MicroRNA Cluster Is Regulated by Multiple Mechanisms in B-Cell Malignancies
• Ming Ji,
• Enyu Rao,
• Himabindu Ramachandrareddy,
• ...
• Wing C. Chan,
• Kai Fu,
• Timothy W. McKeithan
Published online: August 01, 2011
p1645-1656

Protein Signatures for Classification and Prognosis of Gastric Cancer
A Signaling Pathway-Based Approach
• Daguang Wang,
• Fei Ye,
• Yabin Sun,
• ...
• Peng Lee,
• Jian Suo,
• David Y. Zhang
Published online: August 19, 2011
p1657-1666

Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model
• Alexander R. Abbas,
• Janet K. Jackman,
• Sherron L. Bullens,
• ...
• Zora Modrusan,
• Joseph R. Arron,
• Lawren C. Wu
Published online: August 05, 2011
p1667-1680

Cardiovascular, Pulmonary, and Renal Pathology

Adverse Host Factors Exacerbate Occult HIV-Associated Nephropathy
• Dileep Kumar,
• Divya Salhan,
• Sandeep Magoon,
• ...
• Ashwani Malhotra,
• Praveen N. Chander,
• Pravin C. Singhal
Published online: August 25, 2011
p1681-1692

Paigen Diet–Fed Apolipoprotein E Knockout Mice Develop Severe Pulmonary Hypertension in an Interleukin-1–Dependent Manner
• Allan Lawrie,
• Abdul G. Hameed,
• Janet Chamberlain,
• ...
• David G. Kiely,
• David C. Crossman,
• Sheila E. Francis
Published online: August 11, 2011
p1693-1705

Epac1-Mediated, High Glucose–Induced Renal Proximal Tubular Cells Hypertrophy via the Akt/p21 Pathway
• Lin Sun,
• Vinay K. Kondeti,
• Ping Xie,
• Kirtee Raparia,
• Yashpal S. Kanwar
Published online: August 19, 2011
p1706-1718

Angiotensin II Contributes to Podocyte Injury by Increasing TRPC6 Expression via an NFAT-Mediated Positive Feedback Signaling Pathway
• Tom Nijenhuis,
• Alexis J. Sloan,
• Joost G.J. Hoenderop,
• ...
• Jochen Reiser,
• Christian Faul,
• Johan van der Vlag
Published online: August 16, 2011
p1719-1732

Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis
• Cory M. Yamashita,
• Lior Dolgonos,
• Rachel L. Zemans,
• ...
• Naftali Kaminski,
• Christopher A.G. McCulloch,
• Gregory P. Downey
Published online: August 25, 2011
p1733-1745

Transforming Growth Factor-β Regulates the Growth of Valve Interstitial Cells in Vitro
• Chen Li,
• Avrum I. Gotlieb
Published online: August 18, 2011
p1746-1755

Periostin Is Induced in Glomerular Injury and Expressed de Novo in Interstitial Renal Fibrosis
• Kontheari Sen,
• Maja T. Lindenmeyer,
• Ariana Gaspert,
• ...
• Matthias Kretzler,
• Stephan Segerer,
• Clemens D. Cohen
Published online: August 19, 2011
p1756-1767

Cell Injury, Repair, Aging, and Apoptosis

Temporal Smad7 Transgene Induction in Mouse Epidermis Accelerates Skin Wound Healing
• Gangwen Han,
• Fulun Li,
• Peter ten Dijke,
• Xiao-Jing Wang
Published in issue: October 2011
p1768-1779

Autacoid 14S,21R-Dihydroxy-Docosahexaenoic Acid Counteracts Diabetic Impairment of Macrophage Prohealing Functions
• Haibin Tian,
• Yan Lu,
• Shraddha P. Shah,
• Song Hong
Published online: August 12, 2011
p1780-1791

Defective Myofibroblast Formation from Mesenchymal Stem Cells in the Aging Murine Heart
Rescue by Activation of the AMPK Pathway
• Katarzyna A. Cieslik,
• JoAnn Trial,
• Mark L. Entman
Published online: August 05, 2011
p1792-1806

Epithelial and Mesenchymal Cell Biology

Desiccating Stress Induces CD4⁺ T-Cell–Mediated Sjögren's Syndrome–Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-γ
• Xiaobo Zhang,
• Wei Chen,
• Cintia S. De Paiva,
• ...
• Jerry Y. Niederkorn,
• Michael E. Stern,
• Stephen C. Pflugfelder
Published online: August 16, 2011
p1807-1814

Membrane-Bound Serine Protease Inhibitor HAI-1 Is Required for Maintenance of Intestinal Epithelial Integrity
• Makiko Kawaguchi,
• Naoki Takeda,
• Shinri Hoshiko,
• ...
• Tsutomu Yoshikawa,
• Tsuyoshi Fukushima,
• Hiroaki Kataoka
Published online: August 16, 2011
p1815-1826

Gastrointestinal, Hepatobiliary, and Pancreatic Pathology

Twist1 Is Up-Regulated in Gastric Cancer-Associated Fibroblasts with Poor Clinical Outcomes
• Chang Ohk Sung,
• Keun-Woo Lee,
• Songying Han,
• Seok-Hyung Kim
Published online: August 19, 2011
p1827-1838

Kupffer Cells Influence Parenchymal Invasion and Phenotypic Orientation, but Not the Proliferation, of Liver Progenitor Cells in a Murine Model of Liver Injury
• Noémi Van Hul,
• Nicolas Lanthier,
• Regina Español Suñer,
• Jorge Abarca Quinones,
• Nico van Rooijen,
• Isabelle Leclercq
Published online: August 19, 2011
p1839-1850

Aquaporin-1 Promotes Angiogenesis, Fibrosis, and Portal Hypertension Through Mechanisms Dependent on Osmotically Sensitive MicroRNAs
• Robert C. Huebert,
• Kumaravelu Jagavelu,
• Helen I. Hendrickson,
• ...
• Christy E. Trussoni,
• Nicholas F. LaRusso,
• Vijay H. Shah
Published online: August 19, 2011
p1851-1860

Immunopathology and Infectious Diseases

Distinct Developmental Requirements for Isolated Lymphoid Follicle Formation in the Small and Large Intestine
RANKL Is Essential Only in the Small Intestine
• Kathryn A. Knoop,
• Betsy R. Butler,
• Nachiket Kumar,
• Rodney D. Newberry,
• Ifor R. Williams
Published online: August 19, 2011
p1861-1871

A Detrimental Role for Invariant Natural Killer T Cells in the Pathogenesis of Experimental Dengue Virus Infection
• Joelle Renneson,
• Rodrigo Guabiraba,
• Isabelle Maillet,
• ...
• Bernhard Ryffel,
• Mauro M. Teixeira,
• François Trottein
Published online: August 16, 2011
p1872-1883

JNK1, but Not JNK2, Is Required in Two Mechanistically Distinct Models of Inflammatory Arthritis
• Katja Denninger,
• Susanne Rasmussen,
• Jeppe Madura Larsen,
• ...
• Harald Illges,
• Niels Ødum,
• Tord Labuda
Published online: August 16, 2011
p1884-1893

Mast Cell Function and Death in Trypanosoma cruzi Infection
• Marcelo Meuser-Batista,
• José Raimundo Corrêa,
• Vinícius Frias Carvalho,
• ...
• Joseli Lannes-Vieira,
• Robson Coutinho Silva,
• Andrea Henriques-Pons
Published online: August 05, 2011
p1894-1904

The Extent of Desmoglein 3 Depletion in Pemphigus Vulgaris Is Dependent on Ca²⁺-Induced Differentiation
A Role in Suprabasal Epidermal Skin Splitting?
• Volker Spindler,
• Alexander Endlich,
• Eva Hartlieb,
• Franziska Vielmuth,
• Enno Schmidt,
• Jens Waschke
Published online: August 22, 2011
p1905-1916

Interferon-γ Influences the Composition of Leukocytic Infiltrates in Murine Lyme Carditis
• Gregory J. Sabino,
• Sonya J. Hwang,
• Shane C. McAllister,
• Patricio Mena,
• Martha B. Furie
Published online: August 08, 2011
p1917-1928

Increased Expression of Peripheral Blood Leukocyte Genes Implicate CD14⁺ Tissue Macrophages in Cellular Intestine Allograft Rejection
• Chethan Ashokkumar,
• Mylarappa Ningappa,
• Sarangarajan Ranganathan,
• ...
• George Mazariegos,
• Hakon Hakonarson,
• Rakesh Sindhi
Published online: August 19, 2011
p1929-1938

CNS Hypoxia Is More Pronounced in Murine Cerebral than Noncerebral Malaria and Is Reversed by Erythropoietin
• Casper Hempel,
• Valery Combes,
• Nicholas Henry Hunt,
• Jørgen Anders Lindholm Kurtzhals,
• Georges Emile Raymond Grau
Published online: August 19, 2011
p1939-1950

Matrix Pathobiology

Identification and Characterization of Cartilage Oligomeric Matrix Protein as a Novel Pathogenic Factor in Keloids
• Shigeki Inui,
• Fumie Shono,
• Takeshi Nakajima,
• Ko Hosokawa,
• Satoshi Itami
Published online: August 29, 2011
p1951-1960

Prostate Cancer Increases Hyaluronan in Surrounding Nonmalignant Stroma, and This Response Is Associated with Tumor Growth and an Unfavorable Outcome
• Andreas Josefsson,
• Hani Adamo,
• Peter Hammarsten,
• ...
• Anna Engström Laurent,
• Pernilla Wikström,
• Anders Bergh
Published online: August 19, 2011
p1961-1968

Molecular Pathogenesis of Genetic and Inherited Diseases

A Novel Type of Macrothrombocytopenia Associated with a Defect in α2,3-Sialylation
• Claire Jones,
• Jonas Denecke,
• Ronald Sträter,
• ...
• Annette G. Beck-Sickinger,
• Thorsten Marquardt,
• Martin K. Wild
Published online: August 22, 2011
p1969-1977

Amyloidogenicity and Clinical Phenotype Associated with Five Novel Mutations in Apolipoprotein A-I
• Dorota Rowczenio,
• Ahmet Dogan,
• Jason D. Theis,
• ...
• Jenny H. Pinney,
• Philip N. Hawkins,
• Julian D. Gillmore
Published online: August 08, 2011
p1978-1987

Modeling Oculopharyngeal Muscular Dystrophy in Myotube Cultures Reveals Reduced Accumulation of Soluble Mutant PABPN1 Protein
• Vered Raz,
• Samantha Routledge,
• Andrea Venema,
• ...
• Rinse Klooster,
• Michael Antoniou,
• Silvère M. van der Maarel
Published online: August 19, 2011
p1988-2000

Neurobiology

Dendritic Degeneration, Neurovascular Defects, and Inflammation Precede Neuronal Loss in a Mouse Model for Tau-Mediated Neurodegeneration
• Tomasz Jaworski,
• Benoit Lechat,
• David Demedts,
• ...
• Fons Verheyen,
• Sebastian Kügler,
• Fred Van Leuven
Published online: August 12, 2011
p2001-2015

Interleukin-34 Selectively Enhances the Neuroprotective Effects of Microglia to Attenuate Oligomeric Amyloid-β Neurotoxicity
• Tetsuya Mizuno,
• Yukiko Doi,
• Hiroyuki Mizoguchi,
• ...
• Yoshifumi Sonobe,
• Hideyuki Takeuchi,
• Akio Suzumura
Published online: August 29, 2011
p2016-2027

Stimulation of Adult Oligodendrogenesis by Myelin-Specific T Cells
• Helle Hvilsted Nielsen,
• Henrik Toft-Hansen,
• Kate Lykke Lambertsen,
• Trevor Owens,
• Bente Finsen
Published online: August 29, 2011
p2028-2041

A3 Adenosine Receptor Agonist Reduces Brain Ischemic Injury and Inhibits Inflammatory Cell Migration in Rats
• In-Young Choi,
• Jae-Chul Lee,
• Chung Ju,
• ...
• Won Jun Choi,
• Lak Shin Jeong,
• Won-Ki Kim
Published online: August 19, 2011
p2042-2052

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology
Implications for Chronic Pan-TNF-α Suppressive Therapeutic Strategies in the Brain
• Sara L. Montgomery,
• Michael A. Mastrangelo,
• Diala Habib,
• ...
• Sara A. Knowlden,
• Terry W. Wright,
• William J. Bowers
Published online: August 11, 2011
p2053-2070

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain
• Katherine J. Kopeikina,
• George A. Carlson,
• Rose Pitstick,
• ...
• Matthew P. Frosch,
• Bradley T. Hyman,
• Tara L. Spires-Jones
Published online: August 19, 2011
p2071-2082

Tumorigenesis and Neoplastic Progression

A Mouse Mammary Tumor Virus env-Like Exogenous Sequence Is Strictly Related to Progression of Human Sporadic Breast Carcinoma
• Chiara Maria Mazzanti,
• Mohammad Al Hamad,
• Giovanni Fanelli,
• ...
• Mauro Pistello,
• Antonio Giuseppe Naccarato,
• Generoso Bevilacqua
Published online: August 19, 2011
p2083-2090


Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo
• Juping Yuan,
• Mourad Sanhaji,
• Andrea Krämer,
• ...
• Brigitte Zimmer,
• Thorsten Berg,
• Klaus Strebhardt
Published online: August 12, 2011
p2091-2099

CSF1 Expression in Nongynecological Leiomyosarcoma Is Associated with Increased Tumor Angiogenesis
• Iñigo Espinosa,
• Badreddin Edris,
• Cheng-Han Lee,
• ...
• Torsten Nielsen,
• Andrew H. Beck,
• Matt van de Rijn
Published online: August 19, 2011
p2100-2107