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The American Journal of Pathology

American Society for Investigative Pathology

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Issue cover for Volume 186, Issue 2

February 2016

Volume 186Issue 2p211-460

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Open archive funded by American Society for Investigative Pathology

Issue cover for Volume 186, Issue 2

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This Month in AJP

This Month in AJP

Published online: December 31, 2015

p211

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Rous-Whipple Award Lecture

The Mast Cell-IgE Paradox

The Mast Cell-IgE Paradox

From Homeostasis to Anaphylaxis

Stephen J. Galli

Published in issue: February 2016

p212-224

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Mini-Reviews

The Role of the Fibroblast in Inflammatory Upper Airway Conditions

The Role of the Fibroblast in Inflammatory Upper Airway Conditions

Stephen L. Ball,
Derek A. Mann,
Janet A. Wilson,
Andrew J. Fisher

Published online: December 10, 2015

p225-233

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Poly(ADP-Ribose) Polymerases

Poly(ADP-Ribose) Polymerases

New Players in the Pathogenesis of Exocrine Pancreatic Diseases

Neus Martínez-Bosch,
Martin E. Fernández-Zapico,
Pilar Navarro,
José Yélamos

Published online: December 10, 2015

p234-241

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Short Communication

Serum miR-30e and miR-223 as Novel Noninvasive Biomarkers for Hepatocellular Carcinoma

Serum miR-30e and miR-223 as Novel Noninvasive Biomarkers for Hepatocellular Carcinoma

Sourav Bhattacharya,
Robert Steele,
Shubham Shrivastava,
Sounak Chakraborty,
Adrian M. Di Bisceglie,
Ratna B. Ray

Published in issue: February 2016

p242-247

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Regular Articles

Cardiovascular, Pulmonary, and Renal Pathology

Exocytosis of Endothelial Lysosome-Related Organelles Hair-Triggers a Patchy Loss of Glycocalyx at the Onset of Sepsis

Exocytosis of Endothelial Lysosome-Related Organelles Hair-Triggers a Patchy Loss of Glycocalyx at the Onset of Sepsis

Joseph A. Zullo,
Jie Fan,
Tala T. Azar,
...
John M. Tarbell,
Michael S. Goligorsky,
Bingmei M. Fu

Published online: December 09, 2015

p248-258

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Vascular Dysfunction in Pneumocystis-Associated Pulmonary Hypertension Is Related to Endothelin Response and Adrenomedullin Concentration

Vascular Dysfunction in Pneumocystis-Associated Pulmonary Hypertension Is Related to Endothelin Response and Adrenomedullin Concentration

Dan W. Siemsen,
Erin Dobrinen,
Soo Han,
Kari Chiocchi,
Nicole Meissner,
Steve D. Swain

Published online: December 11, 2015

p259-269

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Epithelial and Mesenchymal Cell Biology

AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function

AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function

Deepak Venkatesh,
Dolores Mruk,
Jan M. Herter,
...
Katarzyna Chojnacka,
C. Yan Cheng,
Tanya N. Mayadas

Published online: December 10, 2015

p270-284

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Supplemental Materials

Purinoreceptor P2X7 Regulation of Ca2+ Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury

Purinoreceptor P2X7 Regulation of Ca²⁺ Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury

Martin S. Minns,
Gregory Teicher,
Celeste B. Rich,
Vickery Trinkaus-Randall

Published online: December 09, 2015

p285-296

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Gastrointestinal, Hepatobiliary, and Pancreatic Pathology

Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation

Targeting of Neutrophil Lewis X Blocks Transepithelial Migration and Increases Phagocytosis and Degranulation

Jennifer C. Brazil,
Ronen Sumagin,
Richard D. Cummings,
Nancy A. Louis,
Charles A. Parkos

Published online: December 10, 2015

p297-311

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Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure

Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure

Matthew McMillin,
Gabriel Frampton,
Matthew Quinn,
...
Mario de los Santos III,
Stephanie Grant,
Sharon DeMorrow

Published online: December 09, 2015

p312-323

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Metabolic, Endocrine, and Genitourinary Pathobiology

The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility

The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility

Christoph Schell,
Oliver Kretz,
Wei Liang,
...
Artur Mayerhofer,
Tobias B. Huber,
Florian Grahammer

Published online: December 09, 2015

p324-336

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Molecular Pathogenesis of Genetic and Inherited Diseases

Genome-Wide Uniparental Disomy and Copy Number Variations in Renal Cell Carcinomas Associated with Birt-Hogg-Dubé Syndrome

Genome-Wide Uniparental Disomy and Copy Number Variations in Renal Cell Carcinomas Associated with Birt-Hogg-Dubé Syndrome

Yasuhiro Iribe,
Masahiro Yao,
Reiko Tanaka,
...
Yoji Nagashima,
Yukio Nakatani,
Mitsuko Furuya

Published in issue: February 2016

p337-346

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HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy

HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy

Shabirul Haque,
Xiqian Lan,
Hongxiu Wen,
...
Ashwani Malhotra,
Praveen N. Chander,
Pravin C. Singhal

Published online: December 09, 2015

p347-358

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Musculoskeletal Pathology

Snail Is a Critical Mediator of Invadosome Formation and Joint Degradation in Arthritis

Snail Is a Critical Mediator of Invadosome Formation and Joint Degradation in Arthritis

Annie Lauzier,
Roxane R. Lavoie,
Martine Charbonneau,
Béatrice Gouin-Boisvert,
Kelly Harper,
Claire M. Dubois

Published online: December 15, 2015

p359-374

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Neurobiology

Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease

Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease

Alberto Serrano-Pozo,
Rebecca A. Betensky,
Matthew P. Frosch,
Bradley T. Hyman

Published online: December 11, 2015

p375-384

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Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease

Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease

Marta Blanch,
Jose Luis Mosquera,
Belén Ansoleaga,
Isidre Ferrer,
Marta Barrachina

Published in issue: February 2016

p385-397

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The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method

The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method

Taeko Kimura,
Hiroyuki Hatsuta,
Masami Masuda-Suzukake,
...
Shigeo Murayama,
Masato Hasegawa,
Shin-ichi Hisanaga

Published online: December 11, 2015

p398-409

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Stem Cells, Tissue Engineering, and Hematopoietic Elements

Laminins and Nidogens in the Pericellular Matrix of Chondrocytes

Laminins and Nidogens in the Pericellular Matrix of Chondrocytes

Their Role in Osteoarthritis and Chondrogenic Differentiation

Boris Schminke,
Jenny Frese,
Christa Bode,
Mary B. Goldring,
Nicolai Miosge

Published online: December 09, 2015

p410-418

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Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2

Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2

Jia Shen,
Aaron W. James,
Xinli Zhang,
...
Sotirios Tetradis,
Kang Ting,
Chia Soo

Published online: January 06, 2016

p419-434

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Tumorigenesis and Neoplastic Progression

Mutation-Independent Activation of the Anaplastic Lymphoma Kinase in Neuroblastoma

Mutation-Independent Activation of the Anaplastic Lymphoma Kinase in Neuroblastoma

Marie Regairaz,
Fabienne Munier,
Hervé Sartelet,
...
Stefan Michiels,
Dominique Valteau-Couanet,
Gilles Vassal

Published online: December 11, 2015

p435-445

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Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells

Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells

A Possible Link between Oncomirs and the Vascular Tumor Microenvironment

Esterina D'Asti,
Annie Huang,
Marcel Kool,
...
Andrey Korshunov,
Stefan M. Pfister,
Janusz Rak

Published online: December 11, 2015

p446-459

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Frontmatter

Editorial Board

Published in issue: February 2016

A1-A2

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Table of Contents

Published in issue: February 2016

A3-A5

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