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The American Journal of Pathology

American Society for Investigative Pathology

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Issue cover for Volume 192, Issue 2

February 2022

Volume 192Issue 2p179-390

Open Archive

Open archive funded by American Society for Investigative Pathology

Issue cover for Volume 192, Issue 2

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This Month in AJP

This Month in AJP

Published online: December 14, 2021

p179

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Review

Slide Over

Slide Over

Advances in Slide-Free Optical Microscopy as Drivers of Diagnostic Pathology

Yehe Liu,
Richard M. Levenson,
Michael W. Jenkins

Published online: November 10, 2021

p180-194

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Regular Articles

Animal Models

Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters

Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters

Kathleen R. Mulka,
Sarah E. Beck,
Clarisse V. Solis,
...
Jason S. Villano,
Joseph L. Mankowski
for the Johns Hopkins COVID-19 Hamster Study Group

Published online: November 09, 2021

p195-207

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Biomarkers, Genomics, Proteomics, and Gene Regulation

ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice

ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice

Chandra S. Bathula,
Jian Chen,
Rahul Kumar,
Perry J. Blackshear,
Yogesh Saini,
Sonika Patial

Published online: November 10, 2021

p208-225

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Cardiovascular, Pulmonary, and Renal Pathology

Dedicator of Cytokinesis 2 (DOCK2) Deficiency Attenuates Lung Injury Associated with Chronic High-Fat and High-Fructose Diet–Induced Obesity

Dedicator of Cytokinesis 2 (DOCK2) Deficiency Attenuates Lung Injury Associated with Chronic High-Fat and High-Fructose Diet–Induced Obesity

Guoqing Qian,
Oluwaseun Adeyanju,
Christudas Sunil,
...
Torry A. Tucker,
Steven Idell,
Xia Guo

Published online: November 09, 2021

p226-238

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The Challenge of Long-Term Cultivation of Human Precision-Cut Lung Slices

The Challenge of Long-Term Cultivation of Human Precision-Cut Lung Slices

Eike B. Preuß,
Stephanie Schubert,
Christopher Werlein,
...
Armin Braun,
Danny D. Jonigk,
Mark P. Kühnel

Published online: November 09, 2021

p239-253

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Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis

Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis

Rainer Krebs,
Jussi M. Tikkanen,
Alireza Raissadati,
Maria Hollmén,
Kishor Dhaygude,
Karl B. Lemström

Published online: November 10, 2021

p254-269

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Cell Injury, Repair, Aging, and Apoptosis

The Neuropeptide Alpha-Melanocyte–Stimulating Hormone Is Critical for Corneal Endothelial Cell Protection and Graft Survival after Transplantation

The Neuropeptide Alpha-Melanocyte–Stimulating Hormone Is Critical for Corneal Endothelial Cell Protection and Graft Survival after Transplantation

Zala Lužnik Marzidovšek,
Tomas Blanco,
Zhongmou Sun,
...
Ula V. Jurkunas,
Jia Yin,
Reza Dana

Published online: November 10, 2021

p270-280

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Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

Abbe R. Clark,
Jamie Marshall,
Yiming Zhou,
...
Lan Nguyen,
Fei Chen,
Anna Greka

Published online: November 29, 2021

p281-294

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Gastrointestinal, Hepatobiliary, and Pancreatic Pathology

Experimental Colitis Enhances Temporal Variations in CX3CR1 Cell Colonization of the Gut and Brain Following Irradiation

Experimental Colitis Enhances Temporal Variations in CX3CR1 Cell Colonization of the Gut and Brain Following Irradiation

Ayush Batra,
Triet M. Bui,
Jacob F. Rehring,
...
William A. Muller,
David P. Sullivan,
Ronen Sumagin

Published online: November 09, 2021

p295-307

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Growth Factors, Cytokines, and Cell Cycle Molecules

Collagen XII Regulates Corneal Stromal Structure by Modulating Transforming Growth Factor-β Activity

Collagen XII Regulates Corneal Stromal Structure by Modulating Transforming Growth Factor-β Activity

Mei Sun,
Elena Koudouna,
Devon Cogswell,
Marcel Y. Avila,
Manuel Koch,
Edgar M. Espana

Published online: November 11, 2021

p308-319

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Immunopathology and Infectious Diseases

Delta Variants of SARS-CoV-2 Cause Significantly Increased Vaccine Breakthrough COVID-19 Cases in Houston, Texas

Delta Variants of SARS-CoV-2 Cause Significantly Increased Vaccine Breakthrough COVID-19 Cases in Houston, Texas

Paul A. Christensen,
Randall J. Olsen,
S. Wesley Long,
...
Richard Snehal,
Jimmy Gollihar,
James M. Musser

Published online: November 10, 2021

p320-331

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Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model

Interleukin-17 Receptor E and C-C Motif Chemokine Receptor 10 Identify Heterogeneous T Helper 17 Subsets in a Mouse Dry Eye Disease Model

Junling Wang,
Jin Gong,
Qingguo Yang,
Linglin Wang,
Yan Jian,
Ping Wang

Published in issue: February 2022

p332-343

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Machine Learning, Computational Pathology, and Biophysical Imaging

Discriminating Neoplastic from Nonneoplastic Tissues Using an miRNA-Based Deep Cancer Classifier

Discriminating Neoplastic from Nonneoplastic Tissues Using an miRNA-Based Deep Cancer Classifier

Emily Kaczmarek,
Blake Pyman,
Jina Nanayakkara,
...
Kathrin Tyryshkin,
Neil Renwick,
Parvin Mousavi

Published online: November 10, 2021

p344-352

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Tumorigenesis and Neoplastic Progression

Estrogen Inhibits Epithelial Progesterone Receptor–Dependent Progestin Therapy Efficacy in a Mouse Model of Cervical Cancer

Estrogen Inhibits Epithelial Progesterone Receptor–Dependent Progestin Therapy Efficacy in a Mouse Model of Cervical Cancer

Seunghan Baik,
Fabiola F. Mehta,
Esra Unsal,
Yuri Park,
Sang-Hyuk Chung

Published online: November 10, 2021

p353-360

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Vascular Biology, Atherosclerosis, and Endothelium Biology

Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling

Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling

Devin Cao,
Michael G. Strainic,
Daniel Counihan,
...
Alvin H. Schmaier,
Marvin Nieman,
M. Edward Medof

Published in issue: February 2022

p361-378

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Genetic Deletion of Vascular Endothelial Growth Factor Receptor 2 in Endothelial Cells Leads to Immediate Disruption of Tumor Vessels and Aggravation of Hypoxia

Genetic Deletion of Vascular Endothelial Growth Factor Receptor 2 in Endothelial Cells Leads to Immediate Disruption of Tumor Vessels and Aggravation of Hypoxia

Yasuaki Kido,
Tomofumi Ando,
Takahito Iga,
Masatsugu Ema,
Yoshiaki Kubota,
Ikue Tai-Nagara

Published online: November 30, 2021

p379-388

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Correction

Correction

Correction

Published in issue: February 2022

p389

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Frontmatter

Editorial Board

Published in issue: February 2022

A1-A2

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Table of Contents

Published in issue: February 2022

A3-A4

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